A5103032268- Genetic and phenotypic traits in livestock
- Amphibian and Reptile Biology
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Species Distribution and Climate Change
- Dialysis and Renal Disease Management
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Advanced Glycation End Products research
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Trace Elements in Health
- Bat Biology and Ecology Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Turtle Biology and Conservation
- Primate Behavior and Ecology
- Skin and Cellular Biology Research
- Atherosclerosis and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- RNA and protein synthesis mechanisms
Guangxi Medicinal Botanical Garden
2020-2025
Southern Medical University
2012-2025
Nanfang Hospital
2012-2025
Chengdu Institute of Biology
2016-2025
Chinese Academy of Sciences
2012-2025
University of Chinese Academy of Sciences
2011-2025
Huashan Hospital
2025
Fudan University
2025
Center for Discovery
2025
Hackensack Meridian Health
2025
We evaluated differences in the compositions of faecal microbiota between 52 end stage renal disease (ESRD) patients and 60 healthy controls southern China using quantitative real-time polymerase chain reaction (qPCR) high-throughput sequencing (16S ribosomal RNA V4-6 region) methods. The absolute quantification total bacteria was significantly reduced ESRD (p < 0.01). In three enterotypes, Prevotella enriched group whereas Bacteroides were prevalent (LDA score > 4.5). 11 bacterial taxa...
SummaryBackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) has been increasingly reported worldwide, posing a severe challenge to public health; however, the mechanisms driving its emergence and global dissemination remain unclear.MethodsWe analysed CR-hvKp strains derived from canonical hvKp backgrounds, acquired carbapenemase-encoding gene. These were identified 485 CRKp isolates in CRACKLE-2 China cohort, 259 multi-centre study, 67,631 K. genomes available...
Copy number variations (CNVs) are important and widely distributed in the genome. CNV detection opens a new avenue for exploring genes associated with complex traits humans, animals plants. Herein, we present genome-wide assessment of CNVs that potentially milk composition dairy cattle. In this study, were detected based on whole genome re-sequencing data eight Holstein bulls from four half- and/or full-sib families, extremely high low estimated breeding values (EBVs) protein percentage fat...
Comprehending the determinants of host-associated microbiota is pivotal in microbial ecology. Yet, links between climatic factors and variations necessitate further clarification. Mountain-dwelling amphibians, with limited dispersal abilities, serve as valuable models for addressing these questions. Our study, using 126 amphibian-associated samples (64 gut 62 skin) 101 environmental (51 soil 50 water) from eastern Tibetan Plateau, revealed host primary drivers microbiota. However,...
Carbapenem-resistant and virulence plasmid-harboring Klebsiella pneumoniae (pVir-CRKP) has emerged spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbapenem-resistant K. isolates multicenter US cohort identified 6 pVir-CRKP isolates, including 2 sequence type (ST) 23, ST893, ST11 isolates. Patients infected with experienced high Pitt bacteremia scores 33% 30-day mortality rate. The exhibited significant...
Cardiovascular disease (CVD) is the main cause of death in patients on chronic dialysis. The question whether dialysis modality impacts cardiovascular risk remains to be addressed. China Collaborative Study Dialysis, a multi-centers cohort study, was performed evaluate morbidity during maintenance hemodialysis (HD) and peritoneal (PD). consisted from database 9 largest facilities around China. inclusion period between January 1, 2005, December 2010. defined as presence clinically diagnosed...
The use of whole-genome resequencing to obtain more information on genetic variation could produce a range benefits for the dairy cattle industry, especially with regard increasing milk production and improving composition. In this study, we sequenced genomes eight Holstein bulls from four half- or full-sib families, high low estimated breeding values (EBVs) protein percentage fat at an average effective depth 10×, using Illumina sequencing. Over 0.9 million nonredundant short insertions...
Gastrointestinal microbiota may shape the adaptation of their hosts to different habitats and lifestyles, thereby driving evolutionary diversification. It remains unknown if gastrointestinal diverge in congruence with phylogenetic relationships hosts. To evaluate phylosymbiotic relationships, here we analyzed compositions fecal seven Cervinae species raised Chengdu Zoo. All sampled animals were kept same environmental condition fed identical fodder for years. Results showed that Firmicutes...
Buffalo and cow milk have a very different composition in terms of fat, protein, total solids. For better knowledge such difference, the metabolic profiles characteristics metabolites was investigated Italian Mediterranean buffaloes Chinese Holstein cows were by liquid chromatography tandem-mass spectrometry (LC-MS/MS) this study. Totally, 23 differential identified to be significantly from two species which 15 up-regulated 8 down-regulated buffaloes. Metabolic pathway analysis revealed that...
Climate change has been considered to pose critical threats for wildlife. During the past decade, species distribution models were widely used assess effects of climate on species’ suitable habitats. Among all vertebrates, amphibians are most vulnerable change. This is especially true salamanders, which possess some specific traits such as cutaneous respiration and low vagility. The Wushan salamander (Liua shihi) a threatened protected in China, with its wild population decreasing...
The relationship of dietary copper intake with new-onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association CKD in a 30-year follow-up study from young adulthood midlife. A total 4038 U.S. adults aged 18-30 years and without reduced estimated glomerular filtration rate (eGFR) Coronary Artery Risk Development Young Adults (CARDIA) was included. During follow-up, 642 (15.9%) participants developed CKD. Overall, there U-shaped between (p for nonlinearity =...
The transcriptome sequencing based on Illumina Novaseq 6000 Platform was performed with the untreated seed embryo(DS), stratified embryo(SS), and germinated embryo(GS) of Zanthoxylum nitidum, aiming to explore molecular mechanism regulating dormancy germination Z. nitidum uncover key differentially expressed genes(DEGs). A total 61.41 Gb clean data obtained, 86 386 unigenes an average length 773.49 bp were assembled. 29 290 DEGs screened from three comparison groups(SS vs DS, GS SS, DS),...
Abstract Objective This study aims to improve carbon emission accounting accuracy and provide optimized factors for ultra-low coal-fired power plants by detailed balance analysis based on the Life Cycle Assessment (LCA) method. Methods Emissions were calculated via coal combustion activity LCA respectively, with tracking correlation of influencing (coal consumption, efficiency). Results Weekly emissions peaked midweek, reduced estimates 0.19 MtCO 2 , contributed 95.4% inputs, strong...
The Chinese giant salamander (CGS, Andrias davidianus), a flagship amphibian species, is highly vulnerable to high temperatures, posing significant threat under future climate change. Previous research linked this susceptibility liver energy deficiency, accompanied by shifts in gut microbiota and reduced food conversion rates, raising questions about the role of gut-liver axis mediating heat sensitivity. This study investigated responses larvae temperature gradient (10-30 °C), assessing...
The prevalence of circadian misalignment, particularly social jetlag (SJL), contributes significantly to the epidemic metabolic disorders. However, precise impact SJL on liver has remained poorly elucidated. rhythmicity circulating prolactin (PRL) was evaluated in subjects with and mice under SJL. causative mechanism fatty explored using model wild-type Prl-/- mice. Luciferase reporter assay, electrophoretic mobility shift chromatin immunoprecipitation analysis were used study...
Paratuberculosis is a contagious, chronic and enteric disease in ruminants, which caused by Mycobacterium avium subspecies paratuberculosis (MAP) infection, resulting enormous economic losses worldwide. There currently no effective cure for MAP infection or vaccine, it thus important to explore the genetic variants that contribute host susceptibility MAP, may provide better understanding of mechanisms benefit animal improvement. Herein we performed genome-wide association study (GWAS)...
We have previously identified 11 promising candidate genes for milk composition traits by resequencing the whole genomes of 8 Holstein bulls with extremely high and low estimated breeding values protein fat percentages (high groups), including FCGR2B, CENPE, RETSAT, ACSBG2, NFKB2, TBC1D1, NLK, MAP3K1, SLC30A2, ANGPT1 UGDH those contained 25 indels between groups. In this study, purpose was to further examine whether these candidates significant genetic effects on traits. With PCR product...
Abstract The studies of climatic‐niche shifts over evolutionary time accompanied by key morphological innovations have attracted the interest many researchers recently. We applied ecological niche models (ENMs), ordination method (environment principal component analyses; PCA‐env), combined phylogenetic comparative methods (PCMs), and generalized least squares (PGLS) regression to analyze realized dynamics correspondingly across clades within Scutiger boulengeri throughout their...
The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of AOPP levels with all-cause in hemodialysis (HD) patients.A total 1394 maintenance HD patients complete data on related parameters were included from China Collaborative Study Dialysis (CCSD), a multi-center, prospective cohort study. primary outcome was mortality, secondary cardiovascular disease (CVD) mortality.During median follow-up duration...