A5064402280- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Alkaline Phosphatase Research Studies
- Neurological Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Kidney Injury Research
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Paraoxonase enzyme and polymorphisms
- Esophageal and GI Pathology
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Lipid metabolism and disorders
Xuzhou Medical College
2025
Nanfang Hospital
2012-2025
Southern Medical University
2014-2025
National Clinical Research Center for Digestive Diseases
2021-2025
China Pharmaceutical University
2025
Xuzhou No.1 People's Hospital
2025
Union Hospital
2018-2024
Jilin University
2018-2024
XinHua Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Angiotensin-converting-enzyme inhibitors provide renal protection in patients with mild-to-moderate insufficiency (serum creatinine level, 3.0 mg per deciliter or less). We assessed the efficacy and safety of benazepril without diabetes who had advanced insufficiency.We enrolled 422 a randomized, double-blind study. After an eight-week run-in period, 104 serum levels 1.5 to (group 1) received 20 day, whereas 224 3.1 5.0 2) were randomly assigned receive day (112 patients) placebo then...
Importance The role of mycophenolate mofetil (MMF) in management immunoglobulin A nephropathy (IgAN) remains highly controversial. Objective To evaluate the efficacy and safety MMF patients with IgAN at high risk kidney function loss. Design, Setting, Participants This randomized clinical trial open-label, blinded end-point design was conducted among adults IgAN, proteinuria greater than 1.0 g/d, estimated glomerular filtration rate (eGFR) 30 less 60 mL/min/1.73m 2 or persistent hypertension...
<h3>Background/aims</h3> The authors estimated the association between corneal biomechanical properties and axial length in myopic children verified relationship intraocular pressure (IOP). <h3>Methods</h3> This cross-sectional study included 126 eyes of 63 children, aged 12.02±3.19 years. Corneal hysteresis (CH), resistance factor (CRF), central thickness (CCT) IOP were recorded with Reichert Ocular Response Analyzer. Axial (AL) anterior chamber depth (ACD) measured by IOLMaster, whereas...
The accumulation of advanced oxidation protein products (AOPPs) has been linked to vascular lesions in diabetes, chronic renal insufficiency, and atherosclerosis. However, the signaling pathway involved AOPPs-induced endothelial cells (ECs) perturbation is unknown was investigated. AOPPs modified human serum albumin (AOPPs-HSA) bound receptor for glycation end (RAGE) a dose-dependent saturable manner. AOPPs-HSA competitively inhibited binding soluble RAGE (sRAGE) with its preferential...
Objective— Increased level of plasma advanced oxidation protein products (AOPPs) has been found in patients with uremia and nonuremic subjects coronary artery disease. This study was conducted to test the hypothesis that AOPPs play a causal role atherosclerosis. Methods Results— Hypercholesterolemic (0.5% wt/wt diet) or normal rabbits received either repeated intravenous injections modified rabbit serum albumin (AOPPs-RSA) unmodified RSA for 8 weeks. Compared RSA- vehicle-treated...
Objective This study was undertaken to assess the association between likelihood of surgical recurrence and serum ECP TIgE levels in chronic rhinosinusitis with nasal polyps (CRSwNP). Methodology Clinical information gathered retrospectively from 166 cases surgically treated CRSwNP as well 60 without (CRSsNP). A comparative analysis on total immunoglobulin E (TIgE) eosinophil cationic protein (ECP) carried out two groups. The patients were assigned into non-recurrence groups based...
Accumulation of plasma advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease. However, the biologic consequences AOPP consumption on progression renal disease still are unclear. For testing hypothesis that accelerate disease, Sprague-Dawley rats were subjected to five-sixths nephrectomy (5/6 Nx) or sham operation. Rats each group randomly assigned three subgroups (n = 30 group) and treated repeated intravenous injections AOPP-modified rat serum...
The involvement of inflammatory processes has been recognized in development and/or progression diabetic nephropathy. However, the mechanisms involved pathogenesis renal inflammation have not completely understood. In this study, we tested hypothesis that accumulation advanced oxidation protein products (AOPPs), which occurs diabetes, may promote responses kidney. Streptozotocin-induced rats were randomized to iv injection vehicle, native rat serum albumin (RSA), and AOPPs-modified RSA...
Abstract Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular injury in general diabetic populations. However, HHcy’s role hypertensive patients was not studied. We investigated whether HHcy an independent risk factor for renal function decline development of chronic kidney disease (CKD) men women. This a community-based prospective cohort study 2,387 adults without CKD at baseline, mean follow-up 4.4 years. Baseline levels plasma Hcy, folate, vitamin B12, blood...
Neuroinflammation elicited by microglia plays a key role in periventricular white matter (PWM) damage (PWMD) induced infectious exposure. This study aimed to determine if microglia‐derived interleukin‐1β (IL‐1β) would induce hypomyelination through suppression of maturation oligodendrocyte progenitor cells (OPCs) the developing PWM. Sprague‐Dawley rats (1‐day old) were injected with lipopolysaccharide (LPS) (1 mg/kg) intraperitoneally, following which upregulated expression IL‐1β and IL‐1...
Hypoxic exposure in the perinatal period causes periventricular white matter damage (PWMD), a condition associated with myelination abnormalities. Under hypoxic conditions, glial cells were activated and released large number of inflammatory mediators PWM neonatal brain, which may result oligodendrocyte (OL) loss axonal injury. This study aims to determine if astrocytes are generate proinflammatory cytokines that be coupled oligodendroglial hypomyelination observed PWMD. Twenty-four...
Background Early reduction in albuminuria with an SGLT2 (sodium-glucose cotransporter 2) inhibitor may be a positive indicator of long-term cardiovascular and renal benefits. We assessed changes during the first 12 weeks treatment subsequent risks associated inhibitor, empagliflozin, EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial Type 2 diabetes Mellitus Patients) trial. Methods Results calculated percentage urinary albumin creatinine ratio (UACR) change from baseline to...
The lack of a tool for predicting the response to immunosuppressive therapy in IgA nephropathy (IgAN) limits patient-specific risk stratification and early treatment decision making. Models immunosuppression IgAN that can be applied at time kidney biopsy are needed.This prospective cohort study involved 621 Chinese patients with who were high disease progression had persistent proteinuria ≥1 g/d, despite 3 months optimized supportive care renin-angiotensin system inhibitors. Participants...
Abstract Background Acute worsening of renal function, an independent risk factor for adverse outcomes in acute decompensated heart failure (ADHF), occurs as a consequence new onset kidney injury (AKI) or deterioration pre-existed chronic disease (CKD) (acute-on-chronic injury, ACKI). However, the possible difference prognostic implication between AKI and ACKI has not been well established. Methods We studied all consecutive patients hospitalized with ADHF from 2003 through 2010 Nanfang...
Microglia activation is associated with the development of hypoxic-ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This study aims to determine whether clemastine can improve hypomyelination by suppressing activated microglia and promoting maturation progenitor cells (OPCs) HIBI.A bilateral common carotid artery occlusion (BCCAO) rat model that received continuous intraperitoneal injection (1 mg/kg) for 14...
Short-chain fatty acids (SCFAs) are known to be actively involved in neurological diseases, but their roles hypoxic-ischaemic brain injury (HIBI) unclear. In this study, a rat model of HIBI was established, and study measured the changes IL-6 NOD-like receptor thermal protein domain associated 3 (NLRP3), addition proliferation apoptosis indicators oligodendrocyte precursor cells (OPCs). The mechanism action SCFA on astrocytes also investigated. Astrocytes were subjected hypoxia vitro, OPCs...
A major challenge in the management of immunoglobulin nephropathy (IgAN) is inability to identify patients at high risk for disease progression an early stage. Our objective was determine whether urinary matrix metalloproteinase 7 (MMP-7) a promising predictor IgAN and its addition clinical data time biopsy improves prediction.Prospective observational cohort study China.946 Chinese with followed up median 40 months 1 center serving as training set (n=554) 28 second validation (n =...