A5049086506- Advanced biosensing and bioanalysis techniques
- Complexity and Algorithms in Graphs
- Advanced Graph Theory Research
- DNA and Biological Computing
- Gene Regulatory Network Analysis
- Graph Theory and Algorithms
- Molecular Junctions and Nanostructures
- Advanced Algorithms and Applications
- Immune cells in cancer
- Molecular Communication and Nanonetworks
- Cancer Immunotherapy and Biomarkers
- Advanced Graph Neural Networks
- Constraint Satisfaction and Optimization
- DNA and Nucleic Acid Chemistry
- Machine Learning and Algorithms
- Intelligent Tutoring Systems and Adaptive Learning
- Optimization and Search Problems
- Telemedicine and Telehealth Implementation
- Innovative Teaching and Learning Methods
- Health, Environment, Cognitive Aging
- Digital Mental Health Interventions
- Advanced Computational Techniques and Applications
- Speech Recognition and Synthesis
- Formal Methods in Verification
- Lung Cancer Treatments and Mutations
Yueyang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Shanghai East Hospital
2019-2024
Changzhou No.2 People's Hospital
2021-2024
Nanjing Medical University
2021-2024
Shaanxi Normal University
2022-2023
Yunnan University
2020-2023
Fujian Women and Children Hospital
2023
Bacterial cellulose (BC), a network of pure nanofibers with fine crystallinity, high mechanical strength and wet capability, good biocompatibility, is material candidate for wound dressing. Hyaluronan (HA) has obvious curative properties, promoting the healing skin tissue reducing scar formation. This study explored an "orifice plate" culture method to obtain BC samples different sizes but consistent thicknesses. Novel BC-HA nanocomposites 3-D structure were obtained through solution...
Abstract Triple‐negative breast cancer (TNBC) exhibits resistance to conventional treatments due the presence of stem cells (CSCs), causing postsurgical relapse and a dismal prognosis. Umbilical cord blood natural killer (UCB‐NK) cell‐based immunotherapy represents promising strategy for treatment. However, its therapeutic efficacy is greatly restrained by downregulation NK cell activation ligand MHC class I‐related chain A/B (MICA/B) autophagy‐mediated degradation cell‐derived granzyme B...
We describe an exact branch-and-bound algorithm for the maximum weight clique problem (MWC), called WLMC, that is especially suited large vertex-weighted graphs. WLMC incorporates two original contributions: a preprocessing to derive initial vertex ordering and reduce size of graph, incremental vertex-weight splitting number branches in search space. Experiments on representative graphs from real-world applications show greatly outperforms relevant heuristic MWC algorithms, refute prevailing...
Short-chain fatty acids (SCFAs) are known to be actively involved in neurological diseases, but their roles hypoxic-ischaemic brain injury (HIBI) unclear. In this study, a rat model of HIBI was established, and study measured the changes IL-6 NOD-like receptor thermal protein domain associated 3 (NLRP3), addition proliferation apoptosis indicators oligodendrocyte precursor cells (OPCs). The mechanism action SCFA on astrocytes also investigated. Astrocytes were subjected hypoxia vitro, OPCs...
Just as electronic systems implement computation in terms of voltage (energy per unit charge), molecular compute chemical concentrations (molecules volume). Prior work has established mechanisms for implementing logical and arithmetic functions including addition, multiplication, exponentiation, logarithms with reactions. In this paper, we present a general methodology synchronous sequential computation. We generate four-phase clock signal through robust, sustained oscillations. memory...
This paper presents a methodology for implementing digital logic with molecular reactions based on bistable mechanism representing bits. The value of bit is not determined by the concentration single type; rather, it comparison concentrations two complementary types that determines if "0" or "1". robust: any small perturbation leakage in quickly gets cleared out and signal affected. Based this representation bits, constituent set logical components are implemented. These include...
Functional dyspepsia (FD) is a prevalent global disorder of the upper digestive tract characterized by functional impairment. It often coexists with anxiety/depression, significantly impairing occupational productivity and overall quality life. This study aimed to identify emerging patterns prominent themes within FD anxiety/depression research through bibliometric analysis help explore new innovative avenues for investigating this type FD. A comprehensive review literature encompassing was...
This paper presents a methodology for implementing digital logic with molecular reactions based on bistable mechanism representing bits. The value of bit is not determined by the concentration single type; rather, it comparison concentrations two complementary types that determines if 0 or 1. robust: any small perturbation leakage in quickly gets cleared out and signal affected. Based this representation bits, constituent set logical components are implemented. These include combinational --...
We present a methodology for implementing discrete-time signal processing operations, such as filtering, with molecular reactions. The reactions produce time-varying output quantities of molecules function input according to functional specification. This computation is robust and independent the reaction rates, provided that rate constants fall within coarse categories. describe two approaches: one entails synchronization clock signal, implemented through sustained chemical oscillations;...
Background: Colorectal cancer liver metastasis (CRLM) is one of the most devastated complications colorectal (CRC) and usually indicates a poor prognosis for CRC. The herbal formula Kang-Ai-Jing-Fang (KAJF) has been applied in clinical against CRC several decades, but its underlying mechanism still undetermined.Purpose: study aims to explore anti-metastatic effect KAJF on CRLM by manipulating gut microbiota inhibiting M2-like macrophage activation.Methods: were orally administrated model...
Molecular reactions are a common occurrence in biological systems. These tremendously varied and can be extraordinarily complex. This article, however, shows how abstracting these appropriately provide formalism to describe computation that is familiar electrical engineers computer scientists.
The maximum clique problem (MaxClique for short) consists of searching a complete subgraph in graph. A branch-and-bound (BnB) MaxClique algorithm computes an upper bound the number vertices at every search tree node, to prune subtree rooted node. Existing bounds are usually computed from scratch In this paper, we define incremental bound, called IncUB, which is derived efficiently previous searches instead scratch. Then, describe new BnB algorithm, IncMC2, uses graph coloring and MaxSAT...
Advances in the field of synthetic biology have been key to demonstration molecular computing systems general and DNA particular. This paper presents an overview how continuous-time, discrete-time, digital signal processing can be implemented using reactions DNA. In this paper, discrete-time refer sampled signals with continuous amplitude. Signals that are discrete time steps amplitude referred as signals. Delay elements form transfer reactions. Completion all phases once corresponds a...
MaxSAT reasoning is an effective technology used in modern branch-and-bound (BnB) algorithms for the Maximum Weight Clique problem (MWC) to reduce search space. However, current approach MWC carried out a blind manner and not guided by any relevant strategy. In this paper, we describe new BnB algorithm that incorporates novel two-stage approach. each stage, specialised different tasks. Experiments on extensive set of graphs show implementing significantly outperforms exact heuristic both...
Treatment of cancer with pyroptosis is an emerging strategy. Molecular subtypes based on pyroptosis-related genes(PRGs) seem to be considered more conducive individualized therapy. It meaningful construct a molecular subtypes-related prognostic signature (PMSRPS) predict the overall survival (OS) patients pancreatic adenocarcinoma(PAAD) and guide treatment.Based transcriptome data 23 PRGs, consensus clustering was applied divide TCGA GSE102238 combined cohort into three PRGclusters....
Background Necroptosis is a novel form of controlled cell death that contributes to the progression various illnesses. Nonetheless, function and significance necroptosis in autism spectrum disorders (ASD) remain unknown require further investigation. Methods We utilized single-nucleus RNA sequencing (snRNA-seq) data assess expression patterns children with disorder based on 159 necroptosis-related genes. identified differentially expressed NRGs used an unsupervised clustering approach divide...
Abstract Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation‐caused quenching (ACQ) to aggregation‐induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer further employed construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.