A5009483124- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Glutathione Transferases and Polymorphisms
- Inflammasome and immune disorders
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- Wireless Communication Networks Research
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Optical Wireless Communication Technologies
- Genetics and Neurodevelopmental Disorders
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Ubiquitin and proteasome pathways
Second Affiliated Hospital of Nanchang University
2022-2024
Nanchang University
2022-2024
Anyang Institute of Technology
2024
Northwest A&F University
2023
Background Hepatocellular carcinoma (HCC) is one of the most common malignancies in world, with high incidence, malignancy, and low survival rate. Cuproptosis a novel form cell death mediated by lipoylated TCA cycle proteins-mediated pathway highly associated mitochondrial metabolism. However, relationship between expression level cuproptosis-related genes (CRGs) prognosis HCC still unclear. Methods Combining transcriptomic data from The Cancer Genome Atlas(TCGA) Gene Expression Omnibus...
Previous studies have demonstrated that PANoptosis is strongly correlated with cancer immunity and progression. This study aimed to develop a PANoptosis-related signature (PANRS) explore its potential value in predicting the prognosis immunotherapy response of hepatocellular carcinoma (HCC).Based on expression genes, three molecular subtypes were identified. To construct signature, differentially expressed genes between different subjected multivariate least absolute shrinkage selection...
Pancreatic cancer (PC) is one of the deadliest malignant tumors, and its resistance to gemcitabine chemotherapy primary reason for poor prognosis in patients. Ubiquitin-like protein FAT10 has recently been reported promote tumor resistance. In this study, expression PC was significantly higher than that adjacent noncancerous tissues. Increased related a late TNM stage decreased overall survival. Functional experiments revealed downregulating inhibits proliferation epithelial-mesenchymal...
Disulfidptosis is a newly identified mechanism of cell death triggered by disulfide stress. Thus, gaining comprehensive understanding the disulfidptosis signature present in gastric cancer (GC) could greatly enhance development personalized treatment strategies for this disease. We employed consensus clustering to identify various subtypes and examined distinct tumor microenvironment (TME) associated with each subtype. The (Dis) score was used quantify subtype patient. Subsequently, we...
Genomic instability (GI) is a critical feature of cancer which plays key role in the occurrence and development pancreatic adenocarcinoma (PAAD). Long non-coding RNA (LncRNA) an emerging prognostic biomarker because it involved regulating GI. Recently, researchers used such GI-related LncRNAs (GILncRNAs) to establish signature for patients with helped predicting overall prognosis patients. However, evident that PAAD still lack constructed GILncRNA.The present study screened GILncRNAs from 83...
Treatment of cancer with pyroptosis is an emerging strategy. Molecular subtypes based on pyroptosis-related genes(PRGs) seem to be considered more conducive individualized therapy. It meaningful construct a molecular subtypes-related prognostic signature (PMSRPS) predict the overall survival (OS) patients pancreatic adenocarcinoma(PAAD) and guide treatment.Based transcriptome data 23 PRGs, consensus clustering was applied divide TCGA GSE102238 combined cohort into three PRGclusters....
Background Genomic instability (GI) plays a crucial role in the development of various cancers including hepatocellular carcinoma. Hence, it is meaningful for us to use long non-coding RNAs related genomic construct prognostic signature patients with HCC. Methods Combining lncRNA expression profiles and somatic mutation The Cancer Genome Atlas database, we identified GI-related lncRNAs (GILncRNAs) obtained prognosis-related GILncRNAs through univariate regression analysis. These risk...
Abstract Background Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes (DUBs). It has been reported that dysregulation of deubiquitination leads to carcinogenesis. As member the DUBs family, proteasome 26 S subunit non-ATPase 7 (PSMD7) serves underlying tumour-promoting factor in multiple cancers. However, clinical significance and biological functions PSMD7 pancreatic cancer (PC) remain unclear. Results...
In this paper, we investigate integrated sensing and communication (ISAC) in high-mobility systems with the aid of an intelligent reflecting surface (IRS). To exploit benefits Delay-Doppler (DD) spread caused by high mobility, orthogonal time frequency space (OTFS)-based frame structure transmission framework are proposed. {In such a framework,} first design low-complexity ratio-based algorithm for estimating velocity mobile user. Then, analyze performance terms achievable mean square error...
Colorectal cancer is the second-leading cause of cancer-related mortality in United States. Glutathione S-transferase can affect development cancer. omega 2, a member GST family, plays an important role many tumors. However, 2 colon remains unclear. Herein, our study aimed to investigate exact We used RNA sequencing data from The Cancer Genome Atlas and Genotype-Tissue Expression database analyze expressions. Then, we explore protein information Human Protein Atlas, GeneCards, String...
ABSTRACT Salt stress significantly limits cotton growth and development, making the improvement of salt tolerance critical. CMF genes, containing a single CCT domain, are promising targets for breeding programs. We identified 101 genes from four species. Phylogenetic analysis grouped these into six clusters closely related to Arabidopsis . Gene structure motif showed high conservation, while collinear indicated segmental duplication as key factor in gene family expansion. Promoter predicted...
An increasing number of studies have shown that immune-related long noncoding RNAs (lncRNAs) do not require a unique expression level. This finding may help predict the survival and drug sensitivity patients with colon cancer.We retrieved original transcriptome clinical data from The Cancer Genome Atlas (TCGA), sorted data, differentiated mRNAs lncRNAs, then downloaded genes. Coexpression analysis predicted lncRNAs (irlncRNAs) univariate identified differentially expressed irlncRNAs...