A5053710819- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Nutrition and Physiology
- Heme Oxygenase-1 and Carbon Monoxide
- Regulation of Appetite and Obesity
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Advanced Photocatalysis Techniques
- Covalent Organic Framework Applications
- Biochemical Analysis and Sensing Techniques
- Retinoids in leukemia and cellular processes
- Animal Disease Management and Epidemiology
- Copper-based nanomaterials and applications
- Inflammasome and immune disorders
- Burn Injury Management and Outcomes
- COVID-19 epidemiological studies
- Respiratory Support and Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Cystic Fibrosis Research Advances
- Vagus Nerve Stimulation Research
- Acupuncture Treatment Research Studies
- COVID-19 diagnosis using AI
Xinxiang Medical University
2017-2025
Guang’anmen Hospital
2023
Northwest A&F University
2015-2017
Henan Agricultural University
2009-2013
Silicosis, characterized by interstitial lung inflammation and fibrosis, poses a significant health threat. ATII cells play crucial role in alveolar epithelial repair structural integrity maintenance. Inhibiting cell senescence has shown promise silicosis treatment. However, the mechanism behind silica-induced remains elusive. The study employed male C57BL/6 N mice A549 human to investigate its potential Silicosis was induced via intratracheal instillation of crystalline silica particles,...
COVID-19 may have a demonstrable influence on disease patterns. However, it remained unknown how tuberculosis (TB) epidemics are impacted by the outbreak. The purposes of this study to evaluate impacts outbreak decreases in TB case notifications and forecast epidemiological trends China.The monthly incidents from January 2005 December 2020 were taken. Then, we investigated causal pandemic reductions using intervention analysis under Bayesian structural time series (BSTS) method. Next, split...
In recent years, genome engineering technology has provided unprecedented opportunities for site-specific modification of biological genomes. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 is one such means that can target a specific locus. It been applied in human cells and many other organisms. Meanwhile, to efficiently enrich targeted cells, several surrogate systems have also developed. However, very limited information exists on the...
The high morbidity, complex seasonality, and recurring risk of hand-foot-and-mouth disease (HFMD) exert a major burden in China. Forecasting its epidemic trends is greatly instrumental informing vaccine targeted interventions. This study sets out to investigate the usefulness an advanced exponential smoothing state space framework by combining Box-Cox transformations, Fourier representations with time-varying coefficients autoregressive moving average (ARMA) error correction (TBATS) method...
Objective: We aim to examine the adequacy of an innovation state-space modeling framework (called TBATS) in forecasting long-term epidemic seasonality and trends hemorrhagic fever with renal syndrome (HFRS). Methods: The HFRS morbidity data from January 1995 December 2020 were taken, subsequently, split into six different training testing segments (including 12, 24, 36, 60, 84, 108 holdout monthly data) investigate its predictive ability TBATS method, performance was compared seasonal...
Dysbiosis of gut microbiota (GM) is intricately linked with cognitive impairment and the incidence traumatic brain injury (TBI) in both animal models human subjects. However, there limited understanding impact mechanisms fecal transplantation (FMT) on barrier function treatment TBI induced by gas explosion (GE). We have employed FMT technology to establish dysbiosis male rats, subsequently conducted non-targeted metabolomics diversity analysis explore bacteria potential functional roles....
Hepatitis B (HB) and hepatitis C (HC) place the largest burden in China, a goal of eliminating them as major public health threat by 2030 has been set. Making more informed accurate forecasts their spread is essential for developing effective strategies, heightening requirement early warning to deal with such threat.To monitor HB HC epidemics design paradigmatic seasonal autoregressive fractionally integrated moving average (SARFIMA) projections into 2030, compare effectiveness...
Aims: In addition to reducing the respiratory function, crystalline silica (SiO2) disturbs immune response by affecting cells during progression of silicosis. Regulatory T cell (Treg) differentiation may play a key role in abnormal polarization helper (Th)1 and Th2 development silicosis-induced fibrosis. Alpha-lipoic acid (ALA) has immunomodulatory effects promoting Tregs differentiation. Thus, ALA have therapeutic potential for treating autoimmune disorders patients with However, little is...
Long-chain polyunsaturated fatty acids (LC-PUFA) promote the development of brain and vision fetus, relieve inflammation, inhibit oral dysplasia rumor cell, decrease incidence cardiovascular disease regulate arrhythmia.Δ-6 desaturase is rate-limited enzyme in desaturation process.This study reports cloning, characterization tissue expression a Δ-6 gene chicken.PCR primers were designed based on predicted sequence chicken (accession number: XM421053) used to isolate cDNA fragment 1,323 bp...
1. An F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects chicken PNPLA3 gene on growth and adipose accumulation. 2. Associations between three SNPs (g.40006G > T, g.42344T C g.42404A T) broiler traits were determined using linkage disequilibrium, haplotype construction association analysis. 3. The g.40006G T mutation associated body weights at 4, 6, 8, 10 12 weeks age, carcass weight, evisceration weight semi-evisceration (P <...