A5101682770- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer and Skin Lesions
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Thermal Regulation in Medicine
- Acute Kidney Injury Research
- Circular RNAs in diseases
- Advanced Neuroimaging Techniques and Applications
- Chemotherapy-related skin toxicity
- Salivary Gland Tumors Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Central Venous Catheters and Hemodialysis
- Geomagnetism and Paleomagnetism Studies
- Hippo pathway signaling and YAP/TAZ
- Intracerebral and Subarachnoid Hemorrhage Research
- Sirtuins and Resveratrol in Medicine
- Developmental Biology and Gene Regulation
- Skin and Cellular Biology Research
- Axon Guidance and Neuronal Signaling
- Chronic Kidney Disease and Diabetes
- Computer Graphics and Visualization Techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Huazhong University of Science and Technology
2015-2025
Jiaxing University
2025
Qilu University of Technology
2025
Union Hospital
2015-2025
Jiangsu University of Science and Technology
2024
Yahoo (United Kingdom)
2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Tongji Hospital
2024
Circulating microRNAs are promising biomarkers for non‐invasive testing and dynamic monitoring in cancer patients. However, no consensus exists regarding the normalization of circulating quantification, making results incomparable. We investigated global microRNA profiles to identify a stable endogenous control quantifying using three cohorts ( n = 544), including 168 individuals (healthy subjects those with chronic hepatitis B cirrhosis) 376 patients (hepatocellular, colorectal, lung,...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease, with median survival of 3–5 years following diagnosis. Lung remodeling by invasive fibroblasts hallmark IPF. In this study, we demonstrate that inhibition vimentin intermediate filaments (VimIFs) decreases the invasiveness IPF and confers protection against in murine model experimental lung injury. Increased expression organization VimIFs contribute to property connection deficient cellular autophagy. Blocking VimIF assembly...
// Liang Han 1 , Jiguang Ma 2 Wanxing Duan Lun Zhang Shuo Yu Qinhong Xu Jianjun Lei Xuqi Li 3 Zheng Wang Wu Jason H. Huang 4, 5 Erxi 6 Qingyong Zhenhua Department of Hepatobiliary Surgery, First Affiliated Hospital Xi'an Jiaotong University, 710061, China Anesthesiology, General 4 Neurosurgery, Baylor Scott and White Health Care, Temple, TX, 76508, USA Texas A & M College Medicine, 76504, Pharmaceutical Sciences, Science Center, Station, 77843, Correspondence to: Wu, e-mail:...
Purpose: The distal nephron of kidney plays a pivotal role in advancing acute injury (AKI). Understanding the nephrons AKI and identifying markers injured are critical to comprehending mechanism renal novel therapeutic targets. Methods: We analyzed single-cell RNA sequencing (scRNA-seq) data from mice with induced by ischemia-reperfusion (IR), unilateral ureteral obstruction (UUO), cisplatin (CP), sodium oxalate (SO) lipopolysaccharide (LPS). Additionally, we transcriptomics samples for AKI....
The expression and clinical significance of insulin-like growth factor 1 (IGF-1), binding protein 3 (IGFBP-3), 7 (IGFBP-7) were investigated in serum lung cancer tissues from 57 patients with non-small cell (NSCLC). Lung at different pathologic stages (27 I-II 30 III-IV), normal 17 benign pulmonary disease, samples both disease collected during surgery. Enzyme-linked immunosorbent assay avidin-biotin-peroxidase complex immunohistochemical staining used to detect IGF-1, IGFBP-3, IGFBP-7...
Lead is a persistent inorganic environmental pollutant with global implication for human health. Among the diseases associated lead exposure, damage to central nervous system has received considerable attention. It been reported that long-term exposure increases risk of meningioma; however, underlying mechanism remains poorly understood. Clinical studies have indicated loss-of-function and mutations in neurofibromin-2 (NF2) gene play crucial role promoting meningioma formation. The effect Pb...
In the context of surgical treatment for rectal cancer, dentate line is acknowledged as a critical anatomical landmark. However, prognostic implications invasion (DLI) remain elusive and warrant further investigation. This study aims to evaluate compare outcomes patients with cancer who underwent abdominoperineal resection (APR), distinguishing between those without DLI. Between January 2006 December 2017, this enrolled 1854 APR. The cohort was divided into two groups, namely DLI group (n =...
Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced rectal cancer (LARC). Here, we present the 3-year survival outcomes. In this phase 2 trial, previously untreated T3-4N0M0 or T1-4N + M0 adenocarcinoma received 5 × Gy SCRT over days, two cycles of (200 mg) CAPOX regimen every 3 weeks after 1 week. Total mesorectal excision (TME) was...
Non-small cell lung cancer (NSCLC) continues to top the list of mortalities worldwide. Early diagnosis and therapeutic interventions targeting NSCLC is becoming world's significant challenge. Circular RNAs (circRNAs) are emerging as a group potential biomarkers.Quantitative real-time PCR (qRT-PCR) was employed examine expression circ_0072309 in tissues lines. Cell counting kit 8 (CCK-8), wound healing Transwell assays were used analyze proliferation, migration invasion A549 H1299 cells. The...
Circulating tumor cells (CTCs) that are shed from the primary invade blood stream or surrounding parenchyma to form new tumors. The present study aimed explore underlying mechanism of cisplatin resistance in lung adenocarcinoma CTCs and provide clinical treatment guidance for cancer treatment. samples 6 patients were treated with different concentrations along A549 H1299 cells. sensitivity was explored by detecting inhibitory rate via CCK‑8 assay. related molecular investigated western blot...
The study is aimed at investigating the changes in expressions of heat shock protein 27 (HSP27), HSP70, and soluble glycoprotein (SGP) heart failure (HF) rats complicated with pulmonary edema exploring their potential correlations cardiopulmonary functions. rat model HF was established, were divided into group (model group, <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>15</mn> </math> ) normal ( id="M2"> ). After successful modeling, MRI ECG applied to...
Video-assisted thoracoscopic surgery (VATS) has permeated our thoracic surgical practice and now will develop in depth towards a next level of minimally invasive (MIS). Irrespective generation gaps diversified perception within community, more teams are adapting to the uniportal lobectomy. This video demonstrates case undergoing VATS lobectomy with systematic lymphadenectomy for lung cancer. We here describe technique approach by using combination double-jointed endoscopic instruments combat...
The infiltration of CD8 + T cells in the tumor microenvironment is associated with better survival and immunotherapy response. However, their roles gastric cancer have not been explored so far. In here, profiles GC gene expression were collected from Cancer Genome Atlas database. Single-cell transcriptomic data originated GSE134520. Cell clustering, annotation, T-cell differential genes TISCH We determined 896 by scRNA-seq analysis. After integrating immune-related genes, 174 overlapping...
Objective To evaluate the value of refined extracapsular anatomy combined with carbon nanoparticle suspension tracing technology for protecting parathyroid function and thoroughness lymph node dissection in central region during endoscopic thyroid cancer surgery. Patients methods Retrospective clinical data analysis was performed on 108 patients who underwent surgery at First Affiliated Hospital Wannan Medical College (Yijishan Hospital) from November 2019 to 2022. Before surgery, tests,...
Our goal was to evaluate the outcomes of fenestrated thoracic endovascular aortic repair lesions involving distal arch using single physician-modified stent grafts.This single-centre, retrospective study included 58 consecutive patients (mean age, 57 ± 14 years; 11 women) who underwent for pathologies grafts between November 2015 and December 2018. Indications complicated acute type B dissection or intramural haematoma with an unfavourable proximal landing zone (n = 49), Ia endoleak...
Background Some colorectal adenocarcinoma (CRC) patients are susceptible to recurrence, and they rapidly progress advanced cancer stages have a poor prognosis. There is an urgent need for efficient screening criteria identify who tend relapse in order treat them earlier more systematically. Methods We identified two groups of with significantly different outcomes by unsupervised cluster analysis GSE39582 based on 101 differentially expressed immune genes. To develop accurate specific...
Objective To analyze prevalence and determinants of medical adhesive-related skin injury (MARSI) in peripherally inserted central catheter implanted patients with lung cancer, to create evidence for improved clinical care. Methods A cross-sectional observational study design was adopted. Skin pictures electronic records 200 cancer who visited Shanghai Chest Hospital PICC between June 2017 September were analyzed calculate MARSI identify related factors. Results The 31.5%...
A novel sericin nerve guidance conduit for the repair of peripheral injury is designed and fabricated by L. Wang Z. Wang's research team. On p. 2195, authors show how this conduit, with physical properties optimized towards regeneration, can increase expression neurotrophic factors effectively promote regeneration sciatic nerve, leading to functional recovery comparable that resulted from autograft.