A5100675325- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Acute Myeloid Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Algal biology and biofuel production
- Angiogenesis and VEGF in Cancer
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Treatments and Mutations
- Biofuel production and bioconversion
- RNA Interference and Gene Delivery
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Spinal Cord Injury Research
Union Hospital
2015-2025
Huazhong University of Science and Technology
2015-2025
Qingdao University
2025
Taian City Central Hospital
2025
Binzhou Medical University
2024
Henan Polytechnic University
2024
Harbin Institute of Technology
2022
Second Hospital of Shandong University
2021
Jilin University
2020
Ocean University of China
2018
Background In locally advanced rectal cancer (LARC), preoperative short-course radiotherapy (SCRT) with delayed surgery has been shown to be as effective long-course chemoradiotherapy, only modest benefits. This study aimed evaluate the efficacy and safety of SCRT combined subsequent CAPOX (capecitabine oxaliplatin) anti-PD-1 antibody camrelizumab in patients LARC. Methods was a prospective, single-arm, phase II trial. Treatment-naïve histologically confirmed T3-4N0M0 or T1-4N+M0...
Background Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes the third-line and subsequent treatments of patients microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance antitumor effect immunotherapy. However, RT exposure on receiving ICIs targeted therapy remains unclear. This study aimed to investigate association between clinical responses fruquintinib (a highly selective tyrosine kinase...
Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), what are its underlying mechanisms. In study, we investigated the efficacy of tamoxifen treatment attenuating SCI-induced pathology. Blood-spinal barrier (BSCB) permeability, tissue edema formation, microglial activation, neuronal cell death myelin loss were determined rats...
Abstract Microglia become activated during cerebral ischemia and exert pro‐inflammatory or anti‐inflammatory role dependent of microglial polarization. NADPH oxidase ( NOX )‐dependent reactive oxygen species ROS ) production in microglia plays an important neuronal damage after ischemic stroke. Recently, are consistently reported to participate the activation polarization; 2 inhibition suppression shown shift polarization from M1 toward M2 state The voltage‐gated proton channel, Hv1, is...
The bioactive, signaling lipid, sphingosine-1-phosphate (S1P), and its analog, fingolimod (FTY720), have previously shown neuroprotective effects against ischemic brain injury. However, the underlying mechanisms not yet been fully clarified. roles of autophagy in stroke are being increasingly recognized. In present study, we sought to determine whether S1P pathway is involved neuronal investigate possible following stroke. Interestingly, found that FTY720 significantly attenuates infarct...
NADPH oxidase (NOX)-dependent reactive oxygen species (ROS) production in inflammatory cells including microglia plays an important role demyelination and free radical-mediated tissue injury multiple sclerosis (MS). However, the mechanism underlying microglial ROS remains largely unknown. The voltage-gated proton channel, Hv1, is selectively expressed required for NOX-dependent generation brain. In present study, we sought to determine of Hv1 channels a mouse model cuprizone-induced...
This study aimed to evaluate the efficacy and safety of camrelizumab plus apatinib with or without stereotactic body radiotherapy (SBRT) as first-line therapy for patients hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT).This is a multicenter, open-label, noncomparative, randomized trial that recruited HCC type II/III/IV PVTT, who had not previously received systemic therapy. Patients were randomly assigned (2:1) receive (200 mg, every 3 weeks) (250 day) SBRT [95% planning...
192 Background: We have demonstrated that neoadjuvant SCRT followed by PD-1 inhibitor plus CAPOX for LARC patients (pts) showed a higher pCR rate and well-tolerated safety profile in phase III UNION study. Fruquintinib is potent highly selective VEGFR inhibitor, which had been approved previously treated mCRC pts. This study aimed to investigate the efficacy of fruquintinib adebrelimab as total therapy high-risk Methods: In this prospective, open-label, multi-centers, single-arm 2...
Abstract Efficient bioconversion of acetate-rich lignocellulosic biomass into value-added chemicals remains a major challenge due to the toxicity acetic acid. In this study, we engineered an acid-tolerant Issatchenkia orientalis strain (IoDY01H) capable producing 3-hydroxypropionic acid (3-HP), key bioplastic precursor, from glucose, xylose, and acetate. Using Cas9-based genome editing system with hygromycin B resistance marker, introduced heterologous genes encoding xylose utilization...
407 Background: Preliminary results of the open-label, single-arm phase II study (NCT05625737) had demonstrated combination fruquintinib and sintilimab as a second-line therapy promising anti-tumor activity an acceptable safety profile in pts with advanced GC/GEJC (ASCO-GI 2024. Poster 332). Here, we update focus on subgroup analyses. Methods: Patients (pts) aged 18-75 years who were HER2-negative failed first-line standard treatment enrolled. Eligible received 4mg orally once daily days...
Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced rectal cancer (LARC). Here, we present the 3-year survival outcomes. In this phase 2 trial, previously untreated T3-4N0M0 or T1-4N + M0 adenocarcinoma received 5 × Gy SCRT over days, two cycles of (200 mg) CAPOX regimen every 3 weeks after 1 week. Total mesorectal excision (TME) was...
Tamibarotene (Am80), a poorly water-soluble drug for the treatment of acute promyelocytic leukemia (APL), loaded nanostructured lipid carrier (Am80-NLC) was developed and characterized previously. The purpose present work to develop PEGylated (PEG-NLC) intravenous delivery Am80, with aim further extend circulation in blood decrease adverse events. Am80-loaded PEG-NLC (Am80-PEG-NLC) modified PEG-40 stearate (PEG40-SA, molecular weight 2000 Da) formulated by method melt-emulsification low...
332 Background: The KEYNOTE-061 trial showed that anti-PD-1 monotherapy did not improve overall survival compared to chemotherapy in the second-line treatment of advanced GC/GEJC. Preclinical and clinical data have demonstrated synergistic anti-tumor effect fruquintinib, a highly selective oral VEGFR 1/2/3 inhibitor, combination with immune checkpoint inhibitors (ICIs). Additionally, phase III study (NCT03223376) fruquintinib combined paclitaxel GC/GEJC has yielded positive topline results....
Determining the molecular phenotype is a key to understanding and predicting metastatic potential prognosis for patients with lung cancer. Our previous study demonstrated that increased expression of cyclin‑dependent kinase 5 (CDK5) in non‑small cell cancer (NSCLC) associated poorer prognosis. The present aimed further investigate underlying mechanism CDK5 vitro vivo using A549 human NSCLC line. A 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay was used quantify...