A5101725209- Asthma and respiratory diseases
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Potato Plant Research
- Nanoplatforms for cancer theranostics
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Herbal Medicine Research Studies
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Ovarian cancer diagnosis and treatment
- Ion Transport and Channel Regulation
- Nanoparticle-Based Drug Delivery
- Phytochemical Studies and Bioactivities
- Intraperitoneal and Appendiceal Malignancies
- Uterine Myomas and Treatments
- Mast cells and histamine
- PI3K/AKT/mTOR signaling in cancer
Yantaishan Hospital
2023-2025
Changsha Medical University
2024-2025
Jiangsu Cancer Hospital
2004-2024
Nanjing Medical University
2007-2024
Ningbo University
2024
Weihai Municipal Hospital
2024
In myocardial ischemia/reperfusion injury (MIRI), moderate mitophagy is a protective or adaptive mechanism because of clearing defective mitochondria accumulates during MIRI. However, excessive lead to an increase in and ultimately exacerbate MIRI by causing overproduction uncontrolled production mitochondria. Phosphatase tensin homolog (PTEN)-induced kinase 1 (Pink1), Parkin, FUN14 domain containing (FUNDC1) B-cell leukemia/lymphoma 2 (BCL-2)/adenovirus E1B19KD interaction protein 3 (BNIP3)...
Abstract Bioenergetic therapy is emerging as a promising therapeutic approach. However, its effectiveness restricted by metabolic plasticity, tumor cells switch phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) BAY‐876 (BAY) co‐loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) developed boost energy deprivation synchronous interventions of OXPHOS bioenergetic synergetic with chemodynamic/photothermal (CDT/PTT). The MET can...
We previously showed that ANG II induces mesangial cell (MC) proliferation via the JNK-activator protein-1 pathway. The present study attempted to determine upstream mediators of JNK activation, with emphasis on reactive oxygen species (ROS) and epidermal growth factor (EGF) receptor (EGFR). In cultured human MCs (HMCs), as early 3 min, time dependently increased intracellular ROS production, which was sensitive 10 microM diphenyleneiodonium sulfate 500 apocynin, two structurally distinct...
The aim of the study was to discuss whether anti-asthmatic effect quercetin is related periostin and downstream molecular pathway quercetin's effect.We constructed asthmatic mice, sensitized by ovalbumin, administrated different treatments into mice according experimental design. In this study, we mainly observed inflammatory response, airway fibrosis, hyperresponsiveness in mice. Pathological stains (H&E, PAS, Masson) were performed. We also detected inflammation factors...
Fe3O4-magnetic liposome (MLP) can deliver drugs to target tissues and increase drug efficacy. The present study aimed investigate the effects of solamargine (SM) Fe3O4-SM in pancreatic cancer (PC). Cell viability was detected using a Counting kit‑8 assay. Apoptosis cell cycle progression tested flow cytometry A scratch assay used examine metastasis. Quantitative polymerase chain reaction, western blot analysis or immunohistochemical were performed determine expression factors. Magnetic...
Solamargine (SM), a steroidal alkaloid glycoside purified from the Chinese traditional herb Solanum incanum, is known to possess various biological activities. However, only few previous studies have reported anti-metastatic activity of SM. In present study, inhibitory effects SM on metastatic action were investigated in human HepG2 cells. The proliferation cells was evaluated by MTT and colony formation assays. Wound-healing Transwell assays performed examine migration invasion SM-treated...
The tumor volume of high-grade glioma (HGG) after surgery is usually determined by contrast-enhanced MRI (CE-MRI), but the clinical target remains controversial. Functional magnetic resonance imaging (multimodality MRI) techniques such as perfusion-weighted (PWI) and diffusion-tensor (DTI) can make up for CE-MRI. This study explored survival outcomes failure patterns patients with HGG comparing combination multimodality CE-MRI alone.102 postoperative between 2012 2016 were included. 50...
Objective: This study aimed to investigate the anatomic configuration of blood vessels that contribute portal vein tumor thrombus (PVTT), a common complication hepatocellular carcinoma, in VX2 rabbits. Materials and methods: Peripheral mononuclear cells (MNCs) were isolated labeled using superparamagnetic iron oxide particles vitro. Twenty-four rabbits injected with via establish PVTT model. The (n=6/treatment group) randomly assigned into four groups. Rabbits groups A, B C received an...
<title>Abstract</title> Introduction: Current clinical asthma therapeutic drugs can produce a series of adverse effects when used for long period time or in high doses, so it is urgent to find new strategies. Solasodine inhibit ovalbumin (OVA)-induced type II inflammation mice, but the mechanism still unclear. Mast cell (MCs) degranulation an important part allergic reactions, and Src family kinases (SFKs) are involved activation initiation signal MC degranulation, Lyn, Fyn, Syk among SFKs...