A5059549393- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Posttraumatic Stress Disorder Research
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Birth, Development, and Health
- Child Abuse and Trauma
- Urological Disorders and Treatments
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- RNA modifications and cancer
- Cognitive Abilities and Testing
- Hormonal Regulation and Hypertension
- Neurobiology and Insect Physiology Research
- Advanced Causal Inference Techniques
- Injury Epidemiology and Prevention
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury Research
- Migration, Health and Trauma
- Influenza Virus Research Studies
- Resilience and Mental Health
- Pediatric Hepatobiliary Diseases and Treatments
Centers for Disease Control and Prevention
2015-2025
National Center on Birth Defects and Developmental Disabilities
2019-2025
Carter Center
2018-2024
Washington Center
2019-2022
Emory University
2012-2021
Center for Surveillance, Epidemiology, and Laboratory Services
2020
University of Washington
2016-2019
Triangle
2019
Indianapolis Zoo
2019
Kentucky Science Center
2019
Individual genotypes at specific loci can result in different patterns of DNA methylation. These methylation quantitative trait (meQTLs) influence across extended genomic regions and may underlie direct SNP associations or gene-environment interactions. We hypothesized that the detection meQTLs varies with ancestral population, developmental stage, tissue type. explored this by analyzing seven datasets varied ancestry (African American vs. Caucasian), stage (neonate adult), type (blood four...
DNA methylation is an important epigenetic mechanism that has been linked to complex diseases and of great interest researchers as a potential link between genome, environment, disease. As the scale association studies approaches genome-wide studies, issues such population stratification will need be addressed. It well-documented failure adjust for can lead false positives in genetic but often unaccounted studies. Here, we propose several correct using principal components (PCs) from...
Objective: Increased systemic inflammation is associated with stress-related psychopathology. Specifically, levels of the proinflammatory marker C-reactive protein (CRP) are elevated in individuals posttraumatic stress disorder (PTSD). Furthermore, single-nucleotide polymorphisms (SNPs) CRP gene level, risk for cardiovascular disease, and obesity. The authors examined whether within increased PTSD symptoms fear physiology a civilian population high trauma. Method: Cross-sectional data DNA...
Abstract Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-associated variants from genome-wide association studies (GWAS) may illuminate functional mechanisms underlying genetic variant-disease associations. Here, we perform GWAS of >415 thousand CpG sites in whole blood 4170 individuals map 4.7 million cis- 630 trans- meQTL targeting >120 CpGs. Independent replication is performed 1347 participants two studies. By linking results for...
Childhood abuse can alter biological systems and increase risk for adult psychopathology. Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are a potential mechanism underlying this risk. While associates with methylation of certain genes, particularly those stress response system, no study to date has evaluated oxytocin receptor ( OXTR ). However, studies support role link between adverse outcomes, showing confer greater psychiatric symptoms specific...
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of voltage-gated L-type calcium channel Cav1.2, rank among most consistent and replicable genetics findings psychiatry have been associated with schizophrenia, bipolar disorder major depression. However, genetic variants complex diseases often only confer a marginal increase disease risk, which is additionally influenced by environment. Here we show that embryonic deletion Cacna1c forebrain glutamatergic neurons promotes...
Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and drift a particular HA. Here we present broadly neutralizing human monoclonal antibody with an unusual binding modality. The antibody, designated CT149, was isolated from convalescent patients infected pandemic H1N1 2009. CT149 is found neutralize all tested group 2 some 1 A viruses by inhibiting low pH-induced, HA-mediated membrane...
The amygdala-dependent molecular mechanisms driving the onset and persistence of posttraumatic stress disorder (PTSD) are poorly understood. Recent observational studies have suggested that opioid analgesia in aftermath trauma may decrease development PTSD. Using a mouse model dysregulated fear, we found altered expression within amygdala Oprl1 gene (opioid receptor-like 1), which encodes nociceptin (NOP)/orphanin FQ receptor (NOP-R). Systemic central infusion SR-8993, new highly selective...
Significance Higher circulating pituitary adenylate cyclase-activating polypeptide (PACAP) and a polymorphism in its receptor gene ADCYAP1R1 , cyclase activating 1 type 1, have recently been linked with posttraumatic stress disorder (PTSD) women not men. The current study examined the influence of genotype on brain function among traumatized women. In individuals risk genotype, amygdala showed greater reactivity to threat stimuli decreased functional connectivity hippocampus. had larger...
<h3>Importance</h3>The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamic-pituitary-adrenal axis functioning has been associated with many stress-related psychiatric disorders. The study of intermediate phenotypes, such as emotion-processing biases their neural substrates, provides a way to clarify the mechanisms by which dysregulation mediates risk for disorders.<h3>Objective</h3>To examine whether allelic variations putatively functional...
Background Genome-wide association studies (GWAS) have made little progress in identifying variants linked to depression. We hypothesized that examining depressive symptoms and considering gene–environment interaction (GxE) might improve efficiency for gene discovery. therefore conducted a GWAS genome-wide by environment study (GWEIS) of symptoms. Methods Using data from the SHARe cohort Women's Health Initiative, comprising African Americans (n = 7,179) Hispanics/Latinas 3,138), we examined...
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor (PAC1) play a critical role in biological processes that mediate stress response have been implicated psychological outcome following trauma. Our previous work [Ressler et al. (2011); Nature 470:492-497] demonstrated variant, rs2267735, the gene encoding PAC1 (ADCYAP1R1) is associated with post-traumatic disorder (PTSD) primarily African-American cohort of highly traumatized females. We sought to extend replicate our...
Rationale: Stress is associated with asthma morbidity in Puerto Ricans (PRs), who have reduced bronchodilator response (BDR).Objectives: To examine whether stress and/or a gene regulating anxiety (ADCYAP1R1) BDR PR and non-PR children asthma.Methods: This was cross-sectional study of (percent change FEV1 after BD) 234 PRs ages 9–14 years asthma. We assessed child using the Checklist Children’s Distress Symptoms, maternal Perceived Scale. Replication analyses were conducted two cohorts....
Women are at increased risk of developing post-traumatic stress disorder (PTSD) following a traumatic event. Recent studies suggest that this may be mediated, in part, by circulating estrogen levels. This study evaluated the hypothesis individual variation response to levels contributes fear regulation and PTSD women. We DNA methylation from blood female participants Grady Trauma Project found serum estradiol associates with across genome. For genes expressed blood, we examined association...
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, limitations identifying those at risk. Prior studies suggest that PTSD may a systemic illness, affecting not just the brain, entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, organism-level physiological changes....
Abstract DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues involved synaptic maturation plasticity. Here, through genome-wide differential survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find blood significantly reduced cases versus controls, replicate this two independent cohorts. Our follow-up studies lower associated increased amygdala activation to...
Posttraumatic stress disorder (PTSD), while highly prevalent (7.6% over a lifetime), develops only in subset of trauma-exposed individuals. Genetic risk factors interaction with trauma exposure have been implicated PTSD vulnerability.To examine the association 3755 candidate gene single-nucleotide polymorphisms development history childhood trauma.Genetic study an Ohio National Guard longitudinal cohort (n = 810) predominantly male soldiers European ancestry, replication independent Grady...
Genetic factors appear to be highly relevant predicting differential risk for the development of post‐traumatic stress disorder (PTSD). In a discovery sample, we conducted genome‐wide association study (GWAS) PTSD using small military cohort (Systems Biology Biomarkers Consortium; SBPBC, N = 147) that was designed as case‐controlled sample exposed, recently returning veterans with and without combat‐related PTSD. A significant single nucleotide polymorphism (SNP), rs717947, at chromosome...
Post-traumatic stress disorder (PTSD) develops in only some people following trauma exposure, but the mechanisms differentially explaining risk versus resilience remain largely unknown. PTSD is heritable candidate gene studies and genome-wide association (GWAS) have identified a modest number of genes that reliably contribute to PTSD. New gene-based methods may help identify additional increase for development or severity. We applied testing GWAS data from Grady Trauma Project (GTP),...