A5090456800- Diabetes Management and Research
- Diabetes and associated disorders
- Health and Lifestyle Studies
- Pancreatic function and diabetes
- Diet and metabolism studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Electrochemical sensors and biosensors
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Sensors
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Mobile Health and mHealth Applications
- Diabetes Management and Education
University of Colorado Anschutz Medical Campus
2021-2025
The Medical Center of Aurora
2024
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced death. Calcium channel blockers reduce these effects may be beneficial to preservation type 1 diabetes. Objective To determine the effect of verapamil on function children adolescents with newly diagnosed Design, Setting, Participants This double-blind, randomized clinical trial including aged 7 17 years diabetes who weighed 30 kg...
Importance Near normalization of glucose levels instituted immediately after diagnosis type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have hampered an inability achieve tight glycemic goals. Objective To determine the effectiveness intensive management near on preservation in youth with newly diagnosed diabetes. Design, Setting, and Participants This randomized, double-blind, clinical trial was conducted at 6 centers...
Diabetes affects millions in the US, causing elevated blood glucose levels that could lead to complications like kidney failure and heart disease. Recent development of continuous monitors has enabled a minimally invasive option, but discomfort social factors highlight need for noninvasive alternatives diabetes management. We propose portable sensing system based on glucose's optical activity property which rotates linearly polarized light depending its concentration level. To enable form...
Abstract Aims To understand morning biopsychosocial factors that predict glycemia, adherence, and goal attainment in adolescents young adults (AYA) with type 1 diabetes (T1D) on a daily basis. Methods Eight‐eight AYA (mean 17.6 ± 2.6 years, 54% female, HbA1c 7.9 1.4%, duration 8.5 4.5 years) T1D who use Continuous Glucose Monitoring (CGM) completed 2‐week prospective study. Participants chose self‐management to focus during participation. For six days, participants prospectively 25‐item...
Sleep is key to health maintenance. Adolescents with T1D are at increased risk for sleep disruptions and shorter duration. We examined differences between biological genders in sleep, glycemia HRQOL outcomes youth aged 11-17 yes T1D. 70 (mean 14.5±1.8 yrs, 51% female, 76% Non-Hispanic White) participated an observational study. Actigraphy data (sleep duration, efficiency, onset latency, wake after onset) glycemic from CGM (TIR (70-180mg/dL), time hyperglycemic (>180mg/dL),...
Introduction: Diabetic ketoacidosis (DKA) is the leading cause of mortality among youth with type 1 diabetes (T1D). Guidelines for DKA prevention exist; however, specific guidance about when to check ketones and how manage using insulin pumps automated delivery (AID) systems lacking. Methods: A 35-item online survey exploring clinical ketone management practices T1D in USA was distributed healthcare professionals (HCPs). Survey responses, including multiple-choice Likert scale questions,...
Background. Adolescents and young adults with type 1 diabetes have high HbA1c levels often struggle self-management behaviors attention to care. Hybrid closed-loop systems (HCL) like the t:slim X2 Control-IQ technology (Control-IQ) can help improve glycemic control. The purpose of this study is assess adolescents’ situational awareness their glucose control engagement system determine significant factors in daily Methods. (15–25 years) using participated a 2-week prospective study, gathering...
Quality sleep is essential for physical and mental health, diabetes self-management, school performance adolescents with T1D. Social, environmental, health-related factors are known to impact quality, but few studies have examined sex-related differences in this population. These face unique challenges not quantifiable existing surveys, lending importance firsthand accounts through qualitative methods. We barriers among biologic sexes aged 11-17 years Adolescents (n=32, age 14.5±2.0 years,...
<title>Abstract</title> Diabetes affects millions in the US, causing elevated blood glucose levels that could lead to complications like kidney failure and heart disease. Recent development of a continuous monitors has enabled minimally invasive option, but discomfort social factors highlight need for noninvasive alternatives diabetes management. We propose portable sensing system based on glucose's optical activity property where it rotates linearly polarization light depending its...
Abstract Introduction Sleep is recognized as an important component of health for people with type 1 diabetes (T1D), significant associations identified between sleep quality, glycemic outcomes, and self-management. Adolescents, who are particularly vulnerable to insufficient have difficulty meeting targets, typically experience differences in during the summer versus school months. We examined barriers sufficient fall months amongst adolescents ages 11-17 T1D. Methods Adolescents (n=10,...
Sleep is a key component in health maintenance. Adolescents often struggle to obtain sufficient sleep, and those with T1D are at increased risk for diabetes-related sleep disruptions shorter duration. We sought examine quality glycemic outcomes between youth aged 11-17 T1D, comparing summer (free schedule) fall (school schedule). Twenty (mean 13.8 yrs, 65% female, 90% Non-Hispanic White), ten each during fall, participated an observational study. Participants were age matched due...