A5019147697- Diet and metabolism studies
- Diabetes Management and Research
- Gut microbiota and health
- Folate and B Vitamins Research
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Dietary Effects on Health
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Hemoglobin structure and function
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Prenatal Substance Exposure Effects
- Physical Activity and Health
- Birth, Development, and Health
- Extracellular vesicles in disease
- Gestational Diabetes Research and Management
- Neurological Disorders and Treatments
- Cardiovascular and exercise physiology
Translational Research Institute for Metabolism and Diabetes
2015-2025
Translational Research Institute
2022-2025
AdventHealth Orlando
2020-2024
University of North Carolina at Chapel Hill
2010-2023
Stanford University
2023
AdventHealth Tampa
2023
Stanford Medicine
2022
David H. Murdock Research Institute
2010-2015
University of North Carolina Health Care
2014
Mansfield University
2012
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dietary controls precision required to quantitatively evaluate contributions microbiome. Using Microbiome Enhancer Diet (MBD) designed deliver more substrates colon therefore modulate microbiome, we quantified microbial host balance controlled feeding study with randomized crossover design young, healthy, weight stable males females (NCT02939703). In metabolic ward...
Effect alleles (alleles with a polymorphism that is associated the effect being measured) in small number of single-nucleotide polymorphisms (SNPs) are known to influence dietary requirement for choline. In this study, we examined much larger SNPs (n=200) 10 genes related choline metabolism associations development organ dysfunction (liver or muscle) when 79 humans were fed low-choline diet. We confirmed such as C allele PEMT rs12325817 increase risk developing women they consume diet low...
Methanogens are CH 4 -producing, H 2 -oxidizing archaea. Numerous studies have associated methanogens with obesity, but these results been inconsistent. One possible link to host metabolism may be tied the methanogens′ ability consume , thus reducing partial pressure and thermodynamically enhancing fermentation of sugars short-chain fatty acids (SCFA) that can absorb. Because research linking methanogenesis human is limited, our goal this exploratory analysis was investigate relationships...
Abstract Objective This study tested the hypothesis that treatment with glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from loss of lean and fat mass (metabolic adaptation). Methods Phase 1b, double‐blind, randomized, placebo‐controlled was conducted at two centers inpatient wards. Thirty‐five healthy males females overweight obesity (age = 36.5 ± 7.1 years) were randomized...
Introduction: The magnitude and duration of the elevation in resting energy expenditure after vigorous exercise have not been measured a metabolic chamber. This study investigated effects inserting 45-min cycling bout into daily schedule versus controlled day on 24-h Methods: Ten male subjects (age = 22-33 yr) completed two separate chamber visits (one rest one day), balance was maintained for each visit condition. On day, 45 min at 57% Wmax (mean ± SD 72.8% 5.8% V˙O2max) starting 11:00 a.m....
Choline metabolism is important for very low-density lipoprotein secretion, making this nutritional pathway an contributor to hepatic lipid balance. The purpose of study was assess whether the cumulative effects multiple single nucleotide polymorphisms (SNPs) across genes choline/1-carbon and functionally related pathways increase susceptibility developing steatosis. In biopsy-characterized cases nonalcoholic fatty liver disease controls, we assessed 260 SNPs 21 in metabolism. When were...
Colonic microorganisms have been linked to human health and disease, specifically metabolic disease states such as obesity, but causal relationships remain be established. Previous work demonstrated that interactions between the host's diet intestinal microbiome were associated with energy balance by affecting human's absorption, quantified metabolizable energy. We developed Digestion, Absorption Microbial Metabolism (DAMM) model, which explicitly accounts for contributions of colonic...
Abstract Background. Preclinical literature and behavioral human data suggest that diet profoundly impacts the gut microbiome energy absorption—a key determinant of balance. To determine whether these associations are causal, domiciled controlled feeding studies with precise measurements dietary intake balance needed. Metabolomics—a functional readout modulation—can help identify putative mechanisms mediating effects. We previously demonstrated a high-fiber, minimally processed Microbiome...
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects ~40% of adults, but causal mechanisms remain elusive. Preclinical models implicate the gut microbiota in MASLD pathogenesis, yet translation to humans is hampered by variability microbial composition. We addressed this gap investigating whether stable, quantitative phenotypes including encroachment are pathological features MASLD. Sigmoid colon biopsies were collected from participants with and without imaging-defined...
<p dir="ltr">Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly nonalcoholic fatty (NAFLD), is a growing but often unrecognized medical problem for people with diabetes (particularly type 2 diabetes). Liver health has not been at the forefront of complications tracked prevention, as traditionally done diabetic retinopathy, nephropathy or neuropathy. However, steatosis affects about two out three individuals diabetes, especially when associated obesity, and...