A5003619701- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Iron Metabolism and Disorders
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Vitamin D Research Studies
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- Cystic Fibrosis Research Advances
- Delphi Technique in Research
- Acute Ischemic Stroke Management
- COVID-19 and Mental Health
- Child and Adolescent Health
- Pharmaceutical studies and practices
- Gallbladder and Bile Duct Disorders
- COVID-19 and healthcare impacts
All India Institute of Medical Sciences Jodhpur
2023-2025
Asha Hospital
2025
King's College Hospital NHS Foundation Trust
2015-2024
King's College Hospital
2015-2024
King's College London
2013-2024
University of Cambridge
2024
Amity University
2024
Nanaji Deshmukh Veterinary Science University
2022
Koneru Lakshmaiah Education Foundation
2022
Institute of Medical Sciences
2020-2022
Little is known about vitamin D status and its effect on asthma pathophysiology in children with severe, therapy-resistant (STRA).
The mechanism underlying severe asthma with fungal sensitization (SAFS) is unknown. IL-33 important in fungus-induced exacerbations, but its role unexplored.We sought to determine whether children therapy-resistant mediated by IL-33.Eighty-two (median age, 11.7 years; 63% male) were included. SAFS (n = 38) was defined as specific IgE or skin prick test response positivity Aspergillus fumigatus, Alternaria alternata, Cladosporium herbarum. Clinical features and airway immunopathology...
Deficient type I interferon-β and III interferon-λ induction by rhinoviruses has previously been reported in mild/moderate atopic asthmatic adults. No studies have yet investigated if this occurs severe therapy resistant asthma (STRA). Here, we show that compared with non-allergic healthy control children, bronchial epithelial cells cultured ex vivo from children profoundly impaired mRNA protein response to rhinovirus (RV) polyIC stimulation. Severe treatment asthmatics also exhibited...
1α,25‐Dihydroxyvitamin D 3 (1α25 V it 3) has potent immunomodulatory properties. We have previously demonstrated that 1α25 promotes human and murine IL ‐10‐secreting CD 4 + T cells. Because of the clinical relevance this observation, we characterized these cells further investigated their relationship with F oxp3 regulatory ( reg) increased frequency both ‐10 in vitro. However, was at high concentrations more moderate levels, little coexpression molecules. The ‐cell populations showed...
Neutrophils and IL-17A have been linked mechanistically in models of allergic airways disease associated with asthma severity. However, their role pediatric is unknown.We sought to investigate the neutrophils pathway mediating severe therapy-resistant (STRA).Children STRA (n = 51; age, 12.6 years; range, 6-16.3 years) controls without 15; 4.75 1.6-16 underwent clinically indicated fiberoptic bronchoscopy, bronchoalveolar lavage (BAL), endobronchial brushings, biopsy. Neutrophils, IL-17A,...
BackgroundMepolizumab is approved for patients with severe asthma an eosinophilic phenotype aged 12 or more (United States) 6 (European Union) years, but its long-term use in children to 11 years has not yet been assessed.ObjectiveWe sought assess the safety, efficacy, and pharmacodynamics of mepolizumab phenotype.MethodsIn this open-label, uncontrolled, repeat-dose extension study (NCT02377427), (blood eosinophil counts ≥150 cells/μL at screening ≥300 previous year) received a body...
A 24-day-old female neonate was admitted to the paediatric cardiac intensive care unit with features of cardiogenic shock. She born at term a birthweight 3·75 kg mother history RT-PCR-positive, mild COVID-19 31 weeks gestation, which managed symptomatic and supportive measures. There were no fetal complications during illness. The RT-PCR-negative delivery. Following an uncomplicated vaginal delivery, required for 5 days in neonatal tachypnoea subsequently discharged home normal clinical,...
Abstract We describe a study of oxygen transfer in shake flasks using non‐invasive optical sensor. This investigates the effect different plugs, presence baffles, and type media on dissolved profiles during Escherichia coli fermentation. measured volumetric mass coefficient ( k L ) under various conditions also resistances plugs. Finally, we compared flask with that from stirred tank fermentor. By matching 's were able to obtain similar growth recombinant protein product formation kinetics...
Parental smoking is known to worsen asthma symptoms in children and make them refractory treatment, but the molecular mechanism unclear. Oxidative stress from tobacco smoke has been reported impair histone deacetylase-2 (HDAC2) via phosphoinositide-3-kinase (PI3K)/Akt activation and, thus, reduce corticosteroid sensitivity. The aim of this study was investigate passive smoking-dependent abnormalities alveolar macrophages (AMs) by comparing smoke-exposed non-passive with uncontrolled severe...
<h3>Background</h3> Understanding of immune mechanisms underpinning asthma has emerged from studies in adults. It is increasingly recognised, both immunologically and the development novel therapies, that adult responses cannot be used accurately to predict those children. <h3>Methods</h3> Using a well-defined paediatric cohort severe therapy-resistant (STRA) patients, we investigated cytokine profiles airway by analysis bronchoalveolar lavage fluid. The vitro capacity peripheral blood...
BackgroundRhinovirus infections are the dominant cause of asthma exacerbations, and deficient virus induction IFN-α/β/λ in asthmatic patients is important exacerbation pathogenesis. Mechanisms causing this interferon deficiency unknown.ObjectiveWe sought to investigate expression suppressor cytokine signaling (SOCS) 1 tissues from its possible role impaired virus-induced these patients.MethodsWe assessed SOCS1 mRNA protein levels vitro, bronchial biopsy specimens, mice. The was inferred by...
The ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits locally aggressive behavior with high level recurrence, being believed theoretically to come from dental lamina remains, the enamel organ in development, cover cysts or cells basal layer oral mucosa. Especially larger, lesions require more radical surgical approach resulting large jaw defects. This paper discusses our experiences management 20 such patients.A review cases (6 maxillary and 14 mandibular region)...
Abstract Objectives There are no published reports for anti‐interleukin‐5 therapy in children <12 years with asthma. The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics mepolizumab following subcutaneous (SC) administration 6 11 years‐of‐age severe eosinophilic Hypothesis Mepolizumab SC asthma comparable adults. Study Design Multinational, nonrandomised, open‐label (NCT02377427). Patient Selection Children (blood eosinophil count ≥150 cells/µL...
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread through human populations worldwide, presenting across a spectrum of severity from asymptomatic carriage to failure and death.1Wu Z McGoogan JM Characteristics important lessons the disease 2019 (COVID-19) outbreak in China: summary report 72 314 cases Chinese Center for Disease Control Prevention.JAMA. 2020; 323: 1239-1242Crossref PubMed Scopus (12616) Google Scholar, 2Zhou F Yu T Du R et...