A5067221462- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- COVID-19 diagnosis using AI
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- AI in cancer detection
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Health and Wellbeing Research
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Cancer Mechanisms and Therapy
- Liver Diseases and Immunity
- Advanced Sensor and Energy Harvesting Materials
- Endoplasmic Reticulum Stress and Disease
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
Kyungpook National University Hospital
2015-2025
Kyungpook National University
2014-2025
Konkuk University
2018-2025
Seoul National University
2024
Namseoul University
2024
Korea Research Institute of Bioscience and Biotechnology
2024
Sungshin Women's University
2023
Sungkyunkwan University
2020-2022
University of Maryland, Baltimore
2022
Chonnam National University
2022
Federated learning (FL) is a method used for training artificial intelligence models with data from multiple sources while maintaining anonymity, thus removing many barriers to sharing. Here we 20 institutes across the globe train FL model, called EXAM (electronic medical record (EMR) chest X-ray AI model), that predicts future oxygen requirements of symptomatic patients COVID-19 using inputs vital signs, laboratory and X-rays. achieved an average area under curve (AUC) >0.92 predicting...
Exosomal noncoding RNAs (ncRNAs) have unique expression profiles reflecting the characteristics of a tumor, and their role in tumor progression metastasis is emerging. However, significance circulating exosomal ncRNAs prognosis hepatocellular carcinoma (HCC) remains to be elucidated. We therefore determined prognostic (miRNA-21 lncRNA-ATB) for human HCC. This prospective study enrolled 79 HCC patients between October 2014 September 2015. Exosomes were extracted from serum samples using...
Abstract Imbuing bio-inspired sensory devices with intelligent functions of human organs has been limited by challenges in emulating the preprocessing abilities such as reception, filtering, adaptation, and memory at device level itself. Merkel cells, which is a part tactile organs, form synapse-like connections afferent neuron terminals referred to cell-neurite complexes. Here, inspired structure complexes, we report flexible, artificial, intrinsic-synaptic organ that mimics using an...
Macropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor conditions. Ferroptosis caused by cysteine depletion plays a pivotal role sorafenib responses during hepatocellular carcinoma (HCC) therapy. However, it is not known whether macropinocytosis functions as alternative acquire sorafenib-treated HCC, and subsequently mitigates sorafenib-induced ferroptosis. This study aimed...
The histologic status of the immune-tolerant (IT) phase chronic hepatitis B relative to long-term outcomes is unclear. This study aimed discover how serological criteria currently in use correspond determining IT and indication for liver biopsy. Patients determined by positive e antigen, virus (HBV) DNA ≥106 IU/mL, normal or minimally elevated alanine aminotransferase (ALT) ≤60 IU/L, who underwent biopsy at three different hospitals were included. distribution phase, defined as fibrosis...
Evidence of the potential benefits long-term oral branched-chain amino acid (BCAA) supplementation in reducing severity liver disease is limited.Patients who were diagnosed with cirrhosis a Child-Pugh (CP) score 8-10 included. The BCAA group consumed BCAAs daily for at least 6 months, and control diet without BCAA. We analyzed improvements based on model end-stage (MELD) score, CP incidence cirrhosis-related complications, event-free survival over 2 years. Among 867 recruited patients, 307...
Clinical evidence for the benefits of branched-chain amino acids (BCAAs) is lacking in advanced liver disease. We evaluated potential long-term oral BCAA supplementation patients with disease.Liver cirrhosis Child-Pugh (CP) scores from 8 to 10 were prospectively recruited 13 medical centers. Patients supplemented 12.45 g daily granules over 6 months, and consuming a regular diet assigned control groups, respectively. The effects using model end-stage disease (MELD) score, CP serum albumin,...
Abstract We fabricated semitransparent and stretchable hybrid Ag-polytetrafluoroethylene (PTFE) conductors on a polyurethane (PU) substrate for use in high-performance wearable self-cleaning sensors. The highly conductive Ag metal PTFE polymer matrix were cosputtered, embedding the self-formed matrix. Depending cosputtering RF DC power ratio, Ag-PTFE showed sheet resistance of 3.09–17.23 Ω/square an optical transparency 25.27–38.49% at wavelength 550 nm. Under optimal conditions, electrode...
As of August 30th, there were in total 25.1 million confirmed cases and 845 thousand deaths caused by coronavirus disease 2019 (COVID-19) worldwide. With overwhelming demands on medical resources, patient stratification based their risks is essential. In this multi-center study, we built prognosis models to predict severity outcomes, combining patients' electronic health records (EHR), which included vital signs laboratory data, with deep learning- CT-based prediction.
Abstract ‘Federated Learning’ (FL) is a method to train Artificial Intelligence (AI) models with data from multiple sources while maintaining anonymity of the thus removing many barriers sharing. During SARS-COV-2 pandemic, 20 institutes collaborated on healthcare FL study predict future oxygen requirements infected patients using inputs vital signs, laboratory data, and chest x-rays, constituting “EXAM” (EMR CXR AI Model) model. EXAM achieved an average Area Under Curve (AUC) over 0.92,...
Abstract Tumor-associated macrophages (TAMs) are vital contributors to the growth, metastasis, and therapeutic resistance of various cancers, including hepatocellular carcinoma (HCC). However, exact phenotype TAMs mechanisms underlying their modulation for purposes have not been determined. Here, we present compelling evidence that glutamine-derived aspartate in stimulates spermidine production through polyamine synthesis pathway, thereby increasing translation efficiency HIF-1α via eIF5A...
The role of body composition parameters in sorafenib-treated hepatocellular carcinoma (HCC) patients is still not fully elucidated. Here, we aimed to evaluate the impact computed tomography (CT)-based on survival such patients. In this multicenter study, analyzed data 245 HCC from January 2008 December 2019. Sarcopenia, visceral obesity, and myosteatosis were defined by using cross-sectional CT images at third lumbar vertebra level. effects these overall (OS) progression-free (PFS)...
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, tissues paired adjacent nontumor collected analyzed miRs expression.MiR-21 was significantly upregulated in relative to tissues. Both did not predict overall survival; however, considered an independent predictor disease...
Background: Advanced liver fibrosis is the most important prognostic factor in nonalcoholic fatty disease (NAFLD). The long noncoding RNA (lncRNA), growth arrest-specific transcript 5 (GAS5), associated with inhibition of fibrogenesis, and its levels are decreased cirrhotic liver. Methods: We analyzed 51 patients NAFLD, diagnosis which was confirmed by biopsy. Expression GAS5 both plasma using a quantitative real-time polymerase chain reaction according to stage. Results: Plasma expression...
Early and accurate diagnosis of Coronavirus disease (COVID-19) is essential for patient isolation contact tracing so that the spread infection can be limited. Computed tomography (CT) provide important information in COVID-19, especially patients with moderate to severe as well those worsening cardiopulmonary status. As an automatic tool, deep learning methods utilized perform semantic segmentation affected lung regions, which establish severity prognosis prediction. Both extent type...
Imaging plays an important role in assessing the severity of COVID-19 pneumonia. Recent research indicates that disease progress propagates from bottom lungs to top. However, chest radiography (CXR) cannot directly provide a quantitative metric radiographic opacities, and existing AI-assisted CXR analysis methods do not quantify regional severity. In this paper, assist analysis, we developed fully automated framework using deep learning-based four-region segmentation detection models...
Background: Comparative outcomes of HBV-infected compensated cirrhosis with low-level viremia (LLV) versus maintained virological response (MVR) are unclear. We conducted a large, multiethnic, multicenter study to examine the natural history LLV MVR in cirrhosis. Patients and Methods: enrolled patients (n=2316) from 19 hospitals South Korea, Singapore, Japan. defined group as untreated ≥1 detectable serum HBV-DNA (20–2000 IU/mL), Spontaneous-MVR spontaneously achieved MVR, antiviral therapy...
Hepatocellular carcinoma (HCC) is a worldwide health problem and it important to understand the mechanistic roles of biomolecules involved in its pathogenesis. Long non-coding RNAs (lncRNAs) are frequently aberrantly expressed various human cancers known play role cancer The aim this study was analyze expression lncRNA-ATB HCC investigate implications for prognoses. In total, 100 samples tissues their corresponding, adjacent, non-cancerous liver were collected. Total extracted levels...
The reliable risk factors for mortality of COVID-19 has not evaluated in well-characterised cohort. This study aimed to identify in-hospital within 56 days patients with severe infection COVID-19.Retrospective multicentre cohort study.Five tertiary hospitals Daegu, South Korea.1005 participants over 19 years old confirmed using real-time PCR from nasopharyngeal and oropharyngeal swabs.The clinical laboratory features receiving respiratory support were analysed ascertain the Cox proportional...
Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver on outcome COVID-19 remains unresolved.<br/>.A total 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed included this study. Clinical outcomes coexisting as well predictors severity and mortality assessed.<br/>.Of 47 (4.7%) had liver-related comorbidities, 14 (1.4%) cirrhosis. Liver cirrhosis was more common severe pneumonia than...
Abstract Research on transient wearable electronics with stretchable components is of increasing interest because their abilities to conform seamlessly human tissues and, more interestingly, disappear from the environment when disposed. To wear them comfortably, component materials must be pliable, tough, stretchable, biocompatible, and disintegrable. However, most biodegradable are not or limiting use in electronics. Herein, these challenges addressed by demonstrating a nanofiber...