A5028952282- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Sympathectomy and Hyperhidrosis Treatments
- Vascular Procedures and Complications
- Cardiac Ischemia and Reperfusion
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Gastroesophageal reflux and treatments
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Eosinophilic Esophagitis
- Peripheral Artery Disease Management
- Cardiovascular Health and Disease Prevention
- IL-33, ST2, and ILC Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Renal and Vascular Pathologies
- Hemodynamic Monitoring and Therapy
- Migraine and Headache Studies
- Vagus Nerve Stimulation Research
- Acute Kidney Injury Research
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
Vienna General Hospital
2003-2025
Medical University of Vienna
2016-2025
Universitätsklinik für Chirurgie Wien
2020
Jagiellonian University
2017-2018
Lodz University of Technology
2018
University of Vienna
1996-2009
University Hospital Innsbruck
2005
Universitätsklinikum Krems
2004-2005
Charité - Universitätsmedizin Berlin
2005
Ohio University
2002-2003
Background Constitutive nitric oxide synthase (cNOS) may produce species involved in ischemia/reperfusion (I/R) injury: NO the presence of sufficient l -arginine and superoxide at diminished local concentration accompanying I/R. Methods Results During hindlimb I/R (2.5 hours/2 hours), vivo was continuously monitored (porphyrinic sensor), (chromatography), (chemiluminescence), injury were measured intermittently. Normal rabbits compared with those infused 4 mg·kg −1 ·min for 1 hour. In both...
Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, cardiovascular outcomes.
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic aneurysm (AAA), located adventitia and intraluminal thrombus. We compared therapeutic potential targeting upstream or downstream effector molecules NET formation 2 murine AAA models based on angiotensin II peri-adventitial elastase application. In both models, NETs were detected formed aneurysms at treatment start. Although inhibitors failed model, they prevented progression II–induced with thrombus,...
Abstract Tissue factor (TF) is the primary trigger of coagulation. Elevated levels TF are found in atherosclerotic plaques and leads to thrombus formation when released upon plaque rupture. Interleukin (IL)-33 was previously shown induce angiogenesis inflammatory activation endothelial cells (ECs). Here, we investigated impact IL-33 on human ECs, as a possible new link between inflammation induced mRNA protein umbilical vein ECs coronary artery ECs. IL-33-induced expression ST2-...
Background: Covid-19 is an infectious disease caused by invasion of the alveolar epithelial cells coronavirus 19. The most severe outcome Acute Respiratory Distress Syndrome (ARDS) combined with hypoxemia and cardiovascular damage. ARDS co-morbidities are associated inflammatory cytokine storms, sympathetic hyperactivity, respiratory dysfunction. Hypothesis: In present paper, we justify a novel potential treatment for Covid19-originated co-morbidities, based on non-invasive stimulation...
Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of abdominal aortic aneurysms (AAAs). This study has addressed notion that NET components might serve as AAA biomarkers or novel targets therapy. Thus, parameters neutrophil activation and formation were measured plasma. Their diagnostic marker value was explored 41 patients 38 healthy controls. The parameter citrullinated histone H3 (citH3) then validated 63 controls matched for cardiovascular disease. prognostic...
Over the past years, neutrophil extracellular traps (NETs) were shown to contribute states of acute and chronic inflammatory disease. They are composed expelled chromatin decorated by neutrophil-derived proteins. Therefore, analysis DNA complexes with myeloperoxidase (MPO) ELISA has become an attractive tool measure NET formation in vitro vivo samples. When we used a published MPO-DNA protocol included isotype control for anti-MPO coating antibody, observed high assay specificity prepared...
Background — Peroxynitrite generated from nitric oxide (NO) and superoxide (O 2 − ) contributes to ischemia/reperfusion (I/R) injury. Feedback inhibition of endothelial NO synthase by may inhibit O production also at diminished local l -arginine concentrations accompanying I/R. Methods Results During hindlimb I/R (2.5 hours/2 hours), in vivo was monitored continuously (porphyrinic sensor), high-energy phosphates, reduced oxidized glutathione (chromatography), injury were measured...
Type 2 diabetes is associated with microvascular damage that causes frequent infections in the skin and chronic ulcers as a result of impaired wound healing. To trace pathological changes, we performed comprehensive analysis lymphatic vessels type diabetic versus nondiabetic patients. The dermis revealed enhanced vessel density, transcriptional profiling ex vivo isolated endothelial cells (LECs) identified 160 genes differentially expressed between LECs. Bioinformatic deregulated uncovered...
Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils, has been described as biomarker of inflammatory states. Type 2 diabetes mellitus (T2DM) is characterized increased inflammation and elevated risk for embolization carotid artery stenosis (CAS). We aimed to explore the role NGAL systemically in plaques diabetics undergoing endarterectomy. Moreover, potential anti-inflammatory effect metformin on was addressed diabetics. Serum matrix...
Neutrophil gelatinase associated lipocalin (NGAL) is expressed in atherosclerotic lesions and was recently implicated the pathogenesis of cardiovascular pathologies. Statins are known to exert stabilizing effects on plaque. The aims our study were (1) investigate association serum NGAL metalloproteinase (MMP)-9/NGAL complex with vulnerability plaque, (2) reveal statin treatment circulating MMP-9/NGAL levels patients carotid artery stenosis.We examined blood samples from 136 stenosis by...
Monocytes and monocyte-derived microvesicles (MVs) are the main source of circulating tissue factor (TF). Increased monocyte TF expression increased levels procoagulant MVs contribute to formation a prothrombotic state in patients with cardiovascular disease. Interleukin (IL)-33 is pro-inflammatory cytokine involved atherosclerosis other inflammatory diseases, but its role regulating thrombosis still unclear. The aim present study was investigate effects IL-33 on properties human monocytes...
The aim of the study was to assess two disease-specific quality life (QoL) instruments after limited endoscopic thoracic sympathetic block (TS) at T4 for upper limb hyperhidrosis.: Between 2001 and 2005, 112 patients underwent 223 TS procedures in a prospective study. Some 103 (92.0 per cent) had palmar, 87 (77.7 axillary 75 (67.0 combined hyperhidrosis. QoL questionnaires devised by Keller et al. Milanez de Campos were employed before treatment. Mean(s.d.) follow-up 21.9(10.1) months.A...
Text Abstract Aims Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold. Attempts for medical growth abrogation have failed thus far. This study aims to elucidate the heterogeneity of AAA histomorphology in correlation individual patient and metrics. Methods Results Samples from left anterior wall underwent histologic analysis including angiogenesis, calcification, fibrosis, type grade inflammation adventitia media. Clinical information state (intact, symptomatic, ruptured,...
<h3>Hypothesis</h3> Endoscopic thoracic sympathetic block at T4 (ESB4) provides excellent results in patients with primary hyperhidrosis (HH) of the upper limb. Most have combined palmo-plantar or palmo-axillary-plantar HH. This study evaluates clinical outcome limb HH special emphasis on plantar sweating and patients' quality life. <h3>Design</h3> Review a prospectively gathered database. <h3>Setting</h3> Tertiary care university teaching hospital. <h3>Patients</h3> The cohort included 73...