A5071010120- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Frailty in Older Adults
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dialysis and Renal Disease Management
- Neurosurgical Procedures and Complications
- Child Nutrition and Water Access
- Cancer Genomics and Diagnostics
- Spinal Hematomas and Complications
- Intracranial Aneurysms: Treatment and Complications
- Nutritional Studies and Diet
- Cerebrospinal fluid and hydrocephalus
- Endoplasmic Reticulum Stress and Disease
- Electrolyte and hormonal disorders
- Vascular Malformations Diagnosis and Treatment
- Dysphagia Assessment and Management
- Intensive Care Unit Cognitive Disorders
- Abdominal Surgery and Complications
- Spinal Fractures and Fixation Techniques
- Erythropoietin and Anemia Treatment
- Trauma and Emergency Care Studies
- Chronic Kidney Disease and Diabetes
- Advanced Breast Cancer Therapies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Addenbrooke's Hospital
2018-2025
University of Padua
2025
Cambridge University Hospitals NHS Foundation Trust
2025
University of Cambridge
2019-2024
Medical University of Vienna
2014-2023
Statistics Austria
2021-2023
Vienna General Hospital
2020
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020
Zytoprotec (Austria)
2020
University of Illinois Chicago
1992
Chronic subdural hematoma is a common neurologic disorder that especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic has not been well studied.
Insertion of a ventriculoperitoneal shunt for hydrocephalus is one the commonest neurosurgical procedures worldwide. Infection implanted affects up to 15% these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition quality life. Our aim was determine clinical cost-effectiveness antibiotic (rifampicin clindamycin) or silver shunts compared with standard at reducing infection.In this parallel, multicentre, single-blind, randomised controlled trial, we...
Disease-related malnutrition (DRM) is prevalent in hospitals and associated with increased care needs, prolonged hospital stay, delayed rehabilitation death. Nutrition process related activities such as screening, assessment treatment has been advocated by scientific societies patient organizations but implementation variable. We analysed the cross-sectional nutritionDay database for prevalence of nutrition risk factors, processes outcome medical, surgical, long-term other patients (n =...
Background & aimsAcross the globe, prevalence of hospital malnutrition varies greatly depending on population served and local socioeconomic conditions. While is widely recognized to worsen patient outcomes add financial burdens healthcare systems, recent data in Latin America are limited. Our study objectives were: (1) quantify risk American wards, (2) explore associations between nutritional status, in-hospital food intake, health outcomes.MethodsOn nutritionDay (nDay), a specific day...
Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery associated mortality and morbidity, including up to 20% recurrence CSDH. Steroids, such as dexamethasone, have been identified potential therapy for reducing risk in surgically CSDHs. They also used conservative treatment option, thereby avoiding altogether. The hypothesis Dex-CSDH trial that two-week course dexamethasone symptomatic patients CSDH...
Cardiovascular disease (CVD) is the leading cause of increased mortality in patients with CKD and further aggravated by peritoneal dialysis (PD). Children are devoid preexisting CVD provide unique insight into specific uremia- PD-induced pathomechanisms CVD. We obtained specimens from children stage 5 at time PD catheter insertion (CKD5 group), established (PD age-matched nonuremic controls (n=6/group). microdissected omental arterioles tissue layers not directly exposed to fluid used...
NutritionDay (nDay) is a project established by the Medical University of Vienna and European Society for Clinical Nutrition Metabolism (ESPEN) to audit nutritional status hospitalized patients nursing home residents. This study aimed evaluate nDay data describing prevalence hospital malnutrition, risk factors, elements care process implemented in wards 25 countries compare derived from Poland with collected all participating study. In total, 10,863 (European reference group: participants...
Background Chronic subdural haematoma is a collection of ‘old blood’ and its breakdown products in the space predominantly affects older people. Surgical evacuation remains mainstay management symptomatic cases. Objective The Dex-CSDH (DEXamethasone SubDural Haematoma) randomised trial investigated clinical effectiveness cost-effectiveness dexamethasone patients with chronic haematoma. Design This was parallel, superiority, multicentre, pragmatic, controlled trial. Assigned treatment...
The baboon uterus begins to synthesize insulin-like growth factor-binding protein-1 (IGFBP-1) in the deep glands of late secretory endometrium, and this protein then becomes major product term decidua. We hypothesized that placenta and/or conceptus may regulate synthesis secretion IGFBP-1 by decidualized stromal cells during pregnancy. To test hypothesis, tissue was obtained from pregnant baboons on days 18, 25, 32 postovulation. separated into three regions: RI (directly below implantation...
Introduction: Invasive bacterial diseases (IBDs) such as meningitis and sepsis are significant public health concerns, particularly in pediatric populations. This study analyzes the incidence, outcomes, serotype distribution of IBDs Veneto Region over 17 years. Methods: An observational was conducted using data (2007–2023) from surveillance system Region, including microbiologically confirmed cases individuals < 18 Differences by age groups trends were statistically assessed. Results: A...
DIRECT was a prospective, multisite study assessing the feasibility and utility of circulating tumor DNA (ctDNA) in 188 patients with aggressive B-cell non-Hodgkin lymphoma using lymphoma-customized assay open-source pipeline. CtDNA fraction assessed by copy number alterations pre-treatment plasma identified high-risk more effectively than existing clinical risk scores. In 74.5% cases ctDNA equivalent or superior to biopsy for genetic profiling. Patients not suitable genotyping had low...
Abstract Data from clinical trials (CTs) drive advancements in practice. Despite most CTs now incorporating extensive translational portfolios, the diverse modalities of and sample data they generate often remain disconnected underutilised. SYNERGIA is a resource designed to integrate multi-modal multiple comparable format, that will be appropriately accessible clinicians researchers. The aims are to:1) Develop comprehensive, repository integrates longitudinal CT (&gt;5 years), with...
Abstract Background: New therapies are needed for patients who experience primary or secondary resistance to renal cell cancer (RCC) treatment. Pre-clinical data suggests PARP inhibitors may be effective RCC in combination with VEGF inhibitors. Neoadjuvant clinical trials offer an opportunity understand the mechanisms of new by comparing tumour and blood before after Methods: WIRE is a window opportunity, phase II, multi-centre, multi-arm, non-randomised, neoadjuvant trial platform...
Long-term clinical outcome of peritoneal dialysis (PD) depends on adequate removal small solutes and water. The endothelium represents the key barrier transport dysfunction is associated with vascular changes. Alanyl-glutamine (AlaGln) has been shown to counteract PD-induced deteriorations but effect changes not yet elucidated. Using multiplexed proteomic bioinformatic analyses we investigated molecular mechanisms pathology in-vitro (primary human umbilical vein endothelial cells, HUVEC)...
International guidelines recommend routine hospital admission for all patients with mild traumatic brain injury (TBI) who have injuries on computed tomography (CT) scan. Only a small proportion of these require neurosurgical or critical care intervention. We aimed to develop an accurate clinical decision rule identify low-risk safe discharge from the emergency department (ED) and facilitate earlier referral those requiring A retrospective cohort study case notes admitted initial Glasgow Coma...
Abstract Background Monitoring of adequate food intake is not a priority in hospital patients' care. The present study aimed to examine selective data from the nutritionDay survey determine impact during hospitalization on outcomes according nutrition risk status. Methods We conducted descriptive analysis selected 7 consecutive, annual, and cross‐sectional samples 2009 2015. was assessed by univariate multivariate Cox models controlling for PANDORA scores. Results A total 7994 adult patients...
European and North American guidelines on Parenteral Nutrition (PN) large Randomized Controlled Trials give divergent advices nutritional therapeutic strategies for critically ill patients. We therefore investigated differences in of clinicians between Non-European Intensive Care Units (ICU) regarding start day PN, preferred route administration prescription total energy targets over the years. In this study 16,032 patients from 1389 different ICUs were included. Data collection was...
Abstract Background/Objectives Poor food intake is a major etiological factor of malnutrition. This research aims to describe the prevalence recent and current low (LI RC ) identify factors associated with LI in adult hospital patients from different medical specialities. Subject/Methods 1865 participating nutritionDay survey 2016–2020 Germany were included. was defined by decreased eating both on week before hospitalisation. Multivariate binary logistic regression used overall Results...
ICU (intensive care unit) patients are exposed to nutritional risks such as swallowing problems and delayed gastric emptying. A previous stay may affect support upon transfer the ward. The aim was study use of enteral (EN), parenteral nutrition (PN), oral supplements (ONS) in ward with without a stay, also referred post- non-ICU patients. In total, 136,667 adult from nutritionDay audit 2010-2019 were included. defined an during current hospitalisation before nutritionDay. About 10% all...
Hospital length of stay (LOS) is an important clinical and economic outcome knowing its predictors could lead to better planning resources needed during hospitalization. This analysis sought identify structure, patient, nutrition-related LOS available at the time admission in global nutritionDay dataset analyze variations by country for countries with n > 750. Data from 2006-2015 (n = 155,524) was utilized descriptive multivariable cause-specific Cox proportional hazards competing-risks...
Peritoneal dialysis effluent (PDE) represents a rich pool of potential biomarkers for monitoring disease and therapy. Until now, proteomic studies have been hindered by the plasma-like composition PDE. Beads covered with peptide library are promising approach to remove high abundant proteins concentrate sample in one step. In this study, novel biomarker identification PDEs consisting depletion concentration step followed 2D gel based protein quantification was established. To prove...
Abstract The Dex-CSDH trial is a randomised, double-blind, placebo-controlled of dexamethasone for patients with symptomatic chronic subdural haematoma. commenced an internal pilot, whose primary objective was to assess the feasibility multi-centre recruitment. Primary outcome data collection and safety were also assessed, whilst maintaining blinding. We aimed recruit 100 from United Kingdom Neurosurgical Units within 12 months. Trial participants randomised 2-week course or placebo in...
Introduction . Senescence of peritoneal mesothelial cells represents a biological program defined by arrested cell growth and altered secretory phenotype with potential impact in dialysis. This study aims to characterize cellular senescence at the level global protein expression profiles modification proteins O -linked N-acetylglucosamine ( -GlcNAcylation). Methods A comparative proteomics analysis between young senescent human (HPMC) was performed using two-dimensional gel electrophoresis....
Disease related malnutrition (DRM) is prevalent in hospitals and associated with increased care needs, prolonged hospital stay, delayed rehabilitation death. Nutrition process activities such as screening, assessment treatment has been advocated by scientific societies patient organizations but implementation variable. We analyzed the cross-sectional nutritionDay database for prevalence of nutrition risk factors, processes outcome medical patients. In 59126 patients included between...