A5038859646- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Intensive Care Unit Cognitive Disorders
- Myasthenia Gravis and Thymoma
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Ocular Diseases and Behçet’s Syndrome
- Organ Transplantation Techniques and Outcomes
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Pituitary Gland Disorders and Treatments
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Otitis Media and Relapsing Polychondritis
- Respiratory Support and Mechanisms
- Integrated Circuits and Semiconductor Failure Analysis
- Tracheal and airway disorders
- Vascular Anomalies and Treatments
- Peripheral Neuropathies and Disorders
Medical University of Vienna
2018-2025
National Heart Institute
2024
St George's, University of London
2022
Vienna General Hospital
2019-2020
Innsbruck Medical University
2018
Vanda Institute
2017
Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated neurological complications. Furthermore, the adverse effects absent pulsatility cerebral microcirculation are modulated similarly as CO2 vasoreactivity resistance vessels. During support with an device swings arterial carbon dioxide partial pressures (PaCO2) that determine oxygen delivery uncommon-especially when...
Transcatheter aortic valve implantation (TAVI) is rapidly replacing cardiac surgery due to its minimal invasiveness and practicality. Midterm immunological studies on the biocompatibility of galactose-alpha-1,3-galactose (α-Gal)-carrying bioprosthetic heart valves for TAVI are not available. In this study we investigated whether employed augment an α-Gal-specific antibody-dependent antibody-independent immune response 3 months after implantation.This prospective observational included 27...
European and North American guidelines on Parenteral Nutrition (PN) large Randomized Controlled Trials give divergent advices nutritional therapeutic strategies for critically ill patients. We therefore investigated differences in of clinicians between Non-European Intensive Care Units (ICU) regarding start day PN, preferred route administration prescription total energy targets over the years. In this study 16,032 patients from 1389 different ICUs were included. Data collection was...
ICU (intensive care unit) patients are exposed to nutritional risks such as swallowing problems and delayed gastric emptying. A previous stay may affect support upon transfer the ward. The aim was study use of enteral (EN), parenteral nutrition (PN), oral supplements (ONS) in ward with without a stay, also referred post- non-ICU patients. In total, 136,667 adult from nutritionDay audit 2010-2019 were included. defined an during current hospitalisation before nutritionDay. About 10% all...
This population-based cohort study investigated mid-term outcome after surgical aortic valve replacement with a bioprosthetic or mechanical prosthesis in patients aged <50 years European social welfare state.
Abstract Tumor angiogenesis is a key factor in the progression of thymic epithelial tumors (TETs). Activin A, member TGFβ family, and its antagonist Follistatin are involved several human malignancies angiogenesis. We investigated A serum tumor tissue patients with TETs relation to microvessel density (MVD), WHO histology classification, stage outcome. Membranous expression was detected all tissues TETs, while staining found nuclei cytoplasm. Patients presented significantly higher...
Abstract Chronic Lung Allograft Dysfunction (CLAD), manifesting as Bronchiolitis Obliterans Syndrome (BOS) or Restrictive (RAS), is the main reason for adverse long-term outcome after Transplantation (LTX). Until now, no specific biomarkers exist to differentiate between CLAD phenotypes. Therefore, we sought find suitable cytokines distinguish BOS, RAS and Azithromycin Responsive (ARAD); reveal potential similarities differences end-stage fibrotic diseases. We observed significantly...
Background Thymic epithelial tumors (TETs) are rare malignancies with unique association to the autoimmune disease myasthenia gravis (MG). Heat shock proteins (HSPs) harbor great potential as cancer biomarkers and HSP inhibitors approach clinical therapy.Methods To explore pathophysiology, we assessed sera (immunoassays) tissues (immunohistochemistry) of TETs (and thymic tissues) for HSP27, phosphorylated (p)HSP27, HSP70 HSP90α expression in 114 26 non-thymomatous MG patients undergoing...
After major surgery, longitudinal changes in resting energy expenditure (REE) as well imbalances oxygen delivery (DO2) and distribution processing (VO2) may occur due to dynamic metabolic requirements, an impaired macro- microcirculatory flow mitochondrial dysfunction. However, the pattern of these parameters critically ill patients who die during hospitalization remains unknown. Therefore, we analyzed 566 received a pulmonary artery catheter (PAC) their REE, DO2, VO2 extraction ratio (O2ER)...
Abstract Several inflammation-based prognostic scores emerged in various types of cancer to predict clinical outcomes. So far, no accurate pre-treatment scoring systems exist for patients with thymic epithelial tumors (TETs), comprising thymomas and carcinomas (TCs). Therefore, we sought test the value different composite their components, identify optimal cut-off values TETs as well combine predictive components new suitable scores. One hundred eighty-four undergoing surgical tumor...
The clinical relevance of inflammation induced by elective perioperative extracorporeal membrane oxygenation (ECMO) usage as an integral part modern lung transplantation (LUTX) remains elusive. aim this study was to determine the cytokine response accompanying major thoracic surgery employing different devices comprising ECMO, cardiopulmonary bypass (CPB), or no circulation in relation inflammation, clinically tangible increased sequential organ failure assessment (SOFA) score, called...
ObjectivesThe ratio of pulmonary artery (PA) and ascending aorta (AA) diameters has recently been shown to be a useful indicator for disease severity predictor outcome in patients with hypertension heart failure. This study aimed at evaluating the applicability this perioperative risk assessment chronic thromboembolic undergoing endarterectomy.MethodsIn retrospective cohort on 149 endarterectomy between 2013 2020, preoperative PA AA was analyzed axial computed tomography. Variables...
Abstract Objectives To assess demographical and clinical data in a Middle‐European cohort of patients with Adamantiades–Behçet's disease ( ABD ), together the use medication adherence to international guidelines. Methods In retrospective study, in‐ outpatients an Austrian secondary tertiary university hospital center were analyzed independent from medical discipline involved. After ethics approval, screening for ‐patients information system resulted 1821 documents 1997 2016. Patients...
To the best of our knowledge, a strategic approach to define contents structured clinical documentation tools for both routine patient care and research purposes has not been reported so far, although electronic health record will become more detailed in future.To achieve an interdisciplinary consensus on checklist be considered preparation disease- situation-specific tools.A 2-round Delphi consensus-based process was conducted with 19 physicians different disciplines 14 students from...
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality characterized by episodes acute exacerbations. Finding systemic biomarker that reliably predicts outcome after an exacerbation remains challenge. Heat shock protein 27 (HSP27) has been previously studied in COPD, however, urine excretion trajectory prognostic value unknown.In this retrospective post hoc analysis prospective study included 253 COPD patients who were hospitalized for exacerbation, 207...