A5073326264- Metabolism and Genetic Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Bacterial Infections and Vaccines
- Mitochondrial Function and Pathology
- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Infectious Encephalopathies and Encephalitis
- Adrenal Hormones and Disorders
- Mosquito-borne diseases and control
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Infant Nutrition and Health
- Hepatitis Viruses Studies and Epidemiology
- Tracheal and airway disorders
- Metabolomics and Mass Spectrometry Studies
- Muscle metabolism and nutrition
- Diabetes and associated disorders
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Complement system in diseases
- Influenza Virus Research Studies
- Vector-borne infectious diseases
Tirol Kliniken
2024
Innsbruck Medical University
2012-2023
Universität Innsbruck
2016-2023
Universitätsklinik für Kinder und Jugendpsychiatrie
2019
University Hospital Innsbruck
2016
Zentrum für Kinderheilkunde
2016
The aim of the study was to evaluate effects universal mass vaccination (UMV) against rotavirus (RV) on hospitalization rates, nosocomial RV infections and RV-gastroenteritis (GE)-associated secondary blood stream (BSI).The retrospective evaluation (2002-2009) by chart analysis included all clinically diagnosed microbiologically confirmed RV-GE cases in a large tertiary care hospital Austria. pre-vaccination period (2002-2005) compared with recommended early funded (2006-2007) (2008-2009)...
In general, a mitochondrial disorder is diagnosed on the basis of symptom combinations and confirmed by genetic findings. However, patients carrying m.3243A>G mutation in tRNA leucine 1 (MT-TL1) do not always meet all proposed criteria for most frequently encountered syndrome "MELAS," an acronym Mitochondrial Encephalomyopathy, Lactic Acidosis, at least one Stroke-like episode. We here present various phenotypic characteristics with particular focus cardiac manifestations.We followed nine (1...
Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral renewal during human life. These processes are expected be accelerated after childhood thymectomy by influence cytomegalovirus (CMV) inducing a prematurely aged immune system. The study aimed investigate proportional changes replicative history CD8+ cells, recent emigrants (RTEs) CD103+ cells (mostly gut-experienced) role Interleukin-(IL)-7 IL-7 receptor...
Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid acylcarnitine metabolic pathways ('metabolomes') adult patients dominant left ventricle, seeking differences between profiles baseline circulations.In an observational matched cross-sectional study, we compared phosphatidylcholine (PC), sphingomyelin (SM), metabolomes (105 analytes; AbsoluteIDQ® p180 kit (Biocrates Life Sciences AG, Innsbruck,...
Zlamy M, Hofer J, Elias Vogel U, Frosch Jungraithmayr T, Zimmerhackl LB, Prelog M. Immunogenicity of meningococcus C vaccination in a patient with atypical hemolytic uremic syndrome (aHUS) on eculizumab therapy. Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: We report successful kidney transplantation 10‐yr‐old boy aHUS and heterozygous factor H mutation using the terminal complement inhibitor to avoid recurrence renal graft. Vaccination against (Men C) is...
Rotavirus (RV)-associated infections account for high numbers of hospitalizations in neonates and young infants. Universal mass vaccination (UMV) has been shown to prevent the burden disease vaccinated children.The present study investigated long-term effects UMV on RV-associated children with particular focus infants (≤42 days old) not eligible vaccination. Ten years Austrian surveillance data were compared, including 10 960 laboratory-confirmed RV cases before (prevaccination period...
It is unclear, whether pediatric patients with type 1 diabetes (T1DM) show immunological alterations typically found in autoimmune conditions resembling immune dysfunction of the thymus, such as decrease naïve T cells, lower cell receptor excision circle (TREC) numbers, telomeric erosion, and diminished interleukin-7 (IL-7) levels. Furthermore, it unknown, long-term therapy insulin, a thymic growth factor, interferes these changes. Therefore, aim this study was to analyze quantity subset its...
Abstract We report the case of a 13‐year‐old girl who presented with fever, headache, nausea and pain behind right ear. Cerebrospinal fluid (CSF; leukocytes 227/μL), electroencephalogram cerebral magnetic resonance imaging were indicative meningoencephalitis. Despite intensive therapy general condition worsened patient was admitted to care unit. Serological analysis CSF serum indicated acute tick‐borne encephalitis virus (TBEV) infection (IgG IgM positive). TBEV has been reported after...
Published data on breast milk feeding in infants suffering from inherited metabolic disorders (IMDs) other than phenylketonuria (PKU) are limited and described outcome is variable.We aimed to evaluate retrospectively whether breastfeeding and/or feasible with IMDs including organic acidemias, fatty acid oxidation disorders, urea cycle aminoacidopathies or of galactose metabolism.Data as well monitoring neurological were collected our database patients the mentioned IMD, who followed center...
Abstract Introduction Metabolomics studies are not routine when quantifying amino acids (AA) in congenital heart disease (CHD). Objectives Comparative analysis of 24 AA serum by traditional high-performance liquid chromatography (HPLC) based on ion exchange and ninhydrin derivatisation followed photometry ( PM ) with ultra-high-performance phenylisothiocyanate tandem mass spectrometry TMS ); interpretation findings CHD patients controls. Methods : Sample as above (total run time, ~ 119 min)....
Abstract Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. We present a 22‐year‐old Caucasian woman with CVID and granulomatous lymphocytic interstitial lung disease who contracted COVID‐19 was successfully treated sotrovimab molnupiravir. This treatment may have contributed to relatively mild course of in our patient.
Abstract Background Cystic fibrosis (CF) is a genetic multisystem disorder. Inflammatory processes, which presumably begin early in infancy, play crucial role the progression of disease. The detection inflammatory biomarkers, especially airways, has therefore gained increasing attention. Due to improved treatment options, patients with CF produce less sputum. Nasal lavage samples represent promising alternative induced sputum or bronchoalveolar specimens. However, methodology cytokine...
Vaccine-preventable diseases remain a major cause of morbidity and mortality in solid-organ transplant candidates recipients. Newer recommendations include vaccination all household members to create herd immunity around the recipient. This study evaluated status pediatric recipients their members.We 30 (14 kidney, 13 liver, 3 heart) (26 siblings, parents) at time transplant.Fourteen (47%) received scheduled vaccinations before were up date for age with diphtheria, tetanus, pertussis;...
Abstract Objectives To assess demographical and clinical data in a Middle‐European cohort of patients with Adamantiades–Behçet's disease ( ABD ), together the use medication adherence to international guidelines. Methods In retrospective study, in‐ outpatients an Austrian secondary tertiary university hospital center were analyzed independent from medical discipline involved. After ethics approval, screening for ‐patients information system resulted 1821 documents 1997 2016. Patients...
Juvenile idiopathic arthritis is a heterogeneous T cell-mediated autoimmune disease with symptoms of premature aging the immune system (immunosenescence). The present work an investigation immunosenescence parameters, such as quantity naive and CD28- cells, cell receptor excision circles, relative telomere length alterations peripheral replication, was performed via comparison case acute exacerbation juvenile against six patients remission age-matched healthy donors over follow-up course 12...