A5008552902- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Polyomavirus and related diseases
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Glycosylation and Glycoproteins Research
- Parvovirus B19 Infection Studies
- Hepatitis Viruses Studies and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- Hepatitis C virus research
- CNS Lymphoma Diagnosis and Treatment
- Photosynthetic Processes and Mechanisms
- Pneumonia and Respiratory Infections
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
RWTH Aachen University
2007-2023
Universitätsklinikum Aachen
2003-2022
Weatherford College
2021
Innsbruck Medical University
2011-2016
Universität Innsbruck
2011-2014
Center for HIV and Hepatogastroenterology
2014
Institute of Medical Microbiology and Hygiene
2003-2007
Max Planck Society
1999
Westfälische Hochschule
1996-1999
n December 2019, an acute lung disease of unknown origin broke out in the Chinese province Hubei.On 7 January 2020, scientists succeeded isolating a new coronavirus (severe respiratory syndrome corona virus 2, SARS-CoV-2) and identifying it as cause virus-induced pneumonia (1, 2).In line with WHO's definition disease, is now referred to 2019 (COVID-19) and, person-to-person droplet infection, rapidly spreading worldwide (3).The clinical manifestation infection highly variable, ranging from...
Human TLR1 plays an important role in host defense against Mycobacterium tuberculosis. Our aim was to analyze the association of loss surface expression and SNPs with susceptibility TB. TLR1neg TLR1pos cells from healthy individuals were identified by flow cytometry compared sequencing. measured using quantitative real-time PCR immunoblotting. SNP analyses TB patients EU-C Ghana performed, genotypes increased risk developing statistically evaluated. Lack accompanied impaired function...
ABSTRACT Detection of human cytomegalovirus (CMV) DNA in clinical specimens is considered a cornerstone the diagnosis CMV disease. The aim this study was to evaluate newly designed LightCycler-based quantitative PCR. Specimens origin ( n = 200) were tested using LightCycler PCR, COBAS AMPLICOR MONITOR (CACM) assay, and qualitative in-house PCR assay for presence DNA. Samples that reactive at least two three assays positive 95 [47.5%]), while samples nonreactive negative 105 [52.5%]). Using...
The human bocavirus (HBoV) was recently isolated from respiratory tract samples. Within a study collective of children with severe lower disease, the patients testing positive for HBoV (12.8%) had higher rate underlying cardiopulmonary disease. Viral loads in specimens varied 10(2) to 10(10) genome equivalents/ml.
Herpes simplex virus type 1 (HSV-1), human cytomegalovirus (HCMV) and Epstein-Barr (EBV) have been suspected to play a causal role in periodontitis pathogenesis. The aim of this study was determine the prevalence these viruses subgingival plaque samples Caucasian patients with generalized aggressive compared periodontally healthy controls.A total 65 unmatched controls from Germany were investigated study. Subgingival analysed for presence HSV-1, EBV HCMV by quantitative real-time polymerase...
The effect of decreased or increased phosphoenolpyruvate carboxylase (PEPC) activity on the CO2 compensation point, respiration in light dark as well partitioning carbon into starch, soluble sugars, organic acids, and amino acids was investigated using transgenic potato plants. Engineered PEPC ranged from 0.5-fold wild-type level antisense plants to 5-fold levels lines overexpressing cppc gene Corynebacterium glutamicum encoding for a not modulated by protein phosphorylation. point...
Abstract Background Lower respiratory tract infections are among the main causes of death. Although there many viruses, diagnostic efforts focused mainly on influenza. The Respiratory Viruses Network (RespVir) collects infection data, primarily from German university hospitals, for a high diversity by pathogens. In this study, we computationally analysed subset RespVir database, covering 217,150 samples tested 17 different viral pathogens in time span 2010 to 2019. Methods We calculated...
Herpesvirus glycoproteins often form specific heterodimers that can fulfil functions cannot be carried out by either of the partners acting alone. This study showed interactions between Epstein–Barr virus (EBV) multi-spanning transmembrane envelope protein BMRF2 and type II membrane BDLF2 influence way in which these proteins are trafficked cell, hence subcellular compartment they accumulate. When expressed transiently mammalian cells, accumulated endoplasmic reticulum (ER), whereas ER Golgi...
Rotavirus (RV)-associated infections account for high numbers of hospitalizations in neonates and young infants. Universal mass vaccination (UMV) has been shown to prevent the burden disease vaccinated children.The present study investigated long-term effects UMV on RV-associated children with particular focus infants (≤42 days old) not eligible vaccination. Ten years Austrian surveillance data were compared, including 10 960 laboratory-confirmed RV cases before (prevaccination period...
Viruses of different families encode for regulators the complement system (RCAs) or acquire such RCAs from host to get protection against complement-mediated lysis (CML). As hepatitis C virus (HCV) shares no genetic similarity any known RCA and is detectable at high titers in sera infected individuals, we investigated whether HCV has adapted host-derived resist CML. Here report that selectively incorporates CD59 while neither CD55, nor CD46 are associated with virus. The presence was shown...
Studies on the immune responses to severe acute respiratory syndrome coronavirus 2 vaccines are necessary evaluate ongoing vaccination programs by correlating serological response data and clinical effectiveness data. We performed a longitudinal immunological profiling of health care workers vaccinated with mRNA-1273 (Moderna, Cambridge, MA, USA). Half these vaccinees had experienced mild disease 2019 (COVID-19) infection in spring 2020 ("COVID-recovered" cohort), whereas other half no...
ABSTRACT The Enzygnost anti-Epstein-Barr virus enzyme-linked immunosorbent assay (ELISA) system, which is based on a defined antigen mixture and detection of antibodies the immunoglobulin G (IgG), IgM, IgA classes, was evaluated for its reliability in diagnosing Epstein-Barr infections childhood. With samples from 66 children, status infection phase were by indirect immunofluorescence anticomplement fluorescence assays: 11 children seronegative, 8 had primary infection, 20 recent or past 27...