Daanya Salmanullah
A5069871114- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Renal cell carcinoma treatment
- Genomics and Rare Diseases
- Chronic Kidney Disease and Diabetes
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Animal Genetics and Reproduction
- Systemic Lupus Erythematosus Research
- Genetic factors in colorectal cancer
- Congenital Diaphragmatic Hernia Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urological Disorders and Treatments
- Lipid Membrane Structure and Behavior
- Celiac Disease Research and Management
- PI3K/AKT/mTOR signaling in cancer
- Renin-Angiotensin System Studies
- Genetic Syndromes and Imprinting
- Single-cell and spatial transcriptomics
- Kidney Stones and Urolithiasis Treatments
- Atherosclerosis and Cardiovascular Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic and Kidney Cyst Diseases
- RNA modifications and cancer
Boston Children's Hospital
2020-2025
Harvard University
2020-2025
Boston Children's Museum
2023
NOS1AP variants impair actin remodeling in podocytes and cause glomerular disease humans, kidney organoids, mice.
Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of chronic kidney disease before age 25 yr. Nephrin, encoded by
ABSTRACT In genetic disease, an accurate expression landscape of disease genes and faithful animal models will enable precise diagnoses therapeutic discoveries, respectively. We previously discovered that variants in NOS1AP , encoding nitric oxide synthase 1 (NOS1) adaptor protein, cause monogenic nephrotic syndrome (NS). Here, we determined intergenic splice product N OS1AP / Nos1ap neighboring C1orf226/Gm7694 which precludes NOS1 binding, is the predominant isoform mammalian kidney...
Abstract Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of childhood chronic kidney disease. Congenital Finnish type (CNF) (MIM# 256300) caused by biallelic variants in gene NPHS1 , encoding nephrin, an integral component filtration barrier. No causal treatments exist, and children inevitably require replacement therapy. In preparation for therapy (GRT) CNF, we established a quantifiable reproducible phenotypic assessment nephrin-deficient CNF mouse model:...
Introduction: Congenital anomalies of the kidney and urinary tract (CAKUT) are most common cause chronic disease in first 3 decades life. Over 40 genes have been identified as causative for isolated human CAKUT. However, many remain unknown, prioritization potential CAKUT candidate is challenging. To develop an independent approach to prioritize genes, we hypothesized that monogenic likely co-expressed along a temporal axis during development with coinciding high expression may represent...
Saida, Ken; Buerger, Florian; Ottlewski, Isabel; Salmanullah, Daanya; Yu, Seyoung; Kolvenbach, Caroline M.; Lemberg, Katharina; Mansour, Bshara; Mertens, Nils D.; Hölzel, Selina; Elmubarak, Izzeldin; Franken, Gijs A.; Schneider, Ronen; Majmundar, Amar J.; Shril, Shirlee; Hildebrandt, Friedhelm Author Information
Hölzel, Selina; Kolvenbach, Caroline M.; Buerger, Florian; Lemberg, Katharina; Saida, Ken; Yu, Seyoung; Salmanullah, Daanya; Mansour, Bshara; Elmubarak, Izzeldin; Mertens, Nils D.; Shril, Shirlee; Hildebrandt, Friedhelm Author Information
Lemberg, Katharina; Hölzel, Selina; Buerger, Florian; Franken, Gijs A.; Kolvenbach, Caroline M.; Saida, Ken; Salmanullah, Daanya; Deutsch, Konstantin; Hildebrandt, Friedhelm Author Information
Buerger, Florian; Liang, Lorrin; Salmanullah, Daanya; Sharma, Vineeta; Ball, David A.; Hildebrandt, Friedhelm; Majmundar, Amar J. Author Information