A5017994509- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Complement system in diseases
- Inflammasome and immune disorders
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Organ Donation and Transplantation
- Neonatal Health and Biochemistry
- Systemic Lupus Erythematosus Research
- Parvovirus B19 Infection Studies
- Renal and related cancers
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Urological Disorders and Treatments
- Adenosine and Purinergic Signaling
- Liver Disease and Transplantation
- Polyomavirus and related diseases
- Urinary Tract Infections Management
- Genetic and Kidney Cyst Diseases
- Vascular anomalies and interventions
Başkent University
2016-2025
Sağlık Bilimleri Üniversitesi
2023
Ministry of Health
2023
St. Luke's Hospital
2022
Başkent University Hospital
2005-2021
Atatürk University
2020
Memorial Ankara Hospital
2020
Karadeniz Technical University
2020
Heidelberg University
2017
University Hospital Heidelberg
2017
Background and objectives Steroid-resistant nephrotic syndrome is a rare kidney disease involving either immune-mediated or genetic alterations of podocyte structure function. The nature, heterogeneity, slow evolution the disorder are major obstacles to systematic genotype-phenotype, intervention, outcome studies, hampering development evidence-based diagnostic therapeutic concepts. To overcome these limitations, PodoNet Consortium has created an international registry for congenital...
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome children with primary steroid-resistant nephrotic syndrome. From PodoNet Registry, we obtained longitudinal clinical for 1354 patients (disease onset at >3 months <20 years age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 kidney biopsy results, 212 an established genetic diagnosis. assessed risk factors ESRD using...
The efficacy of continuous antibiotic prophylaxis in preventing urinary tract infection (UTI) infants with grade III, IV, or V vesicoureteral reflux is controversial. Download a PDF the Research Summary. In this investigator-initiated, randomized, open-label trial performed 39 European centers, we randomly assigned 1 to 5 months age and no previous UTIs receive (prophylaxis group) treatment (untreated for 24 months. primary outcome was occurrence first UTI during period. Secondary outcomes...
Background and objectives Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. Design, setting, participants, & measurements The Comorbidity Children CKD Study a multicenter, prospective, observational study ages 6–17 years old initial GFR of 10–60 ml/min per 1.73 m 2 . cardiovascular status monitored annually, subclinical assessed by noninvasive surrogate markers, including left ventricular mass index, carotid intima-media...
Acute renal failure (ARF) is a common problem in the neonatal intensive care unit (NICU). In most cases, ARF associated with primary condition such as sepsis, metabolic diseases, perinatal asphyxia and/or prematurity. This retrospective study investigated course of illness, therapeutic interventions, early prognosis and risk factors development period. A total 1311 neonates were treated our NICU during 42-month period, 45 these babies had ARF. was defined serum creatinine level above 1.5...
<h3>AIMS</h3> To describe the distribution and features of classic polyarteritis nodosa (PAN) microscopic (MPA) importance antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. <h3>METHODS</h3> Classic PAN was diagnosed 15 patients based on presence aneurysms angiography 10 necrotising vasculitis medium sized arteries five. MPA patients, characteristic findings at renal biopsy six by small arteritis four. Serum ANCA detected initially indirect immunofluorescence (IIF) followed an...
The early impact of renal transplantation on subclinical cardiovascular measures in pediatric patients has not been widely investigated. This analysis is performed for participating the prospective comorbidity children with chronic kidney disease study and focuses effects replacement therapy (RRT) modality receiving a preemptive transplant or started dialysis.We compared indicating organ damage (aortal pulse wave velocity, carotid intima media thickness, left ventricular mass index)...
The uremic toxins indoxyl sulfate (IS) and p-cresyl (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism decline renal excretion. Despite solid experimental evidence for nephrotoxic effects, the impact on progression CKD has not been investigated representative patient cohorts. In this analysis, IS pCS serum concentrations were measured 604 pediatric participants (mean eGFR 27 ± 11 ml/min/1.73m2) at enrolment into prospective...
Objective: Urinary stone disease (USD) is characterized by formation in the urinary system with an approximate prevalence of 5%-10% children. In thisr study, authors investigated metabolic abnormalities that play a role pediatric patients USD admitted to authors' nephrology clinic during last 10 years, demographic characteristics patients, and presenting symptoms. Materials Methods: A total 325 166 boys (51.1%) 159 girls (48.9%), who presented Pediatric Nephrology outpatient center...
ABSTRACT Background Inborn errors of metabolism (IEMs) are inherited diseases causing significant morbidity and mortality, particularly in childhood. Liver transplantation (LT) can be curative or partially effective for these diseases. LT IEMs has increased, making the second most common reason pediatric after biliary atresia. Patients Methods Between 2001 2023, 50 patients with underwent at Başkent University, Ankara Hospital. Data collected retrospectively included diagnosis, gender, age...
<i>Background:</i> Nephropathy is a well-known complication of congenital heart disease (CHD), and the risk developing renal impairment particularly high in patients with cyanotic CHD. Most investigations CHD have involved 20 years older. This study investigated tubule function pediatric CHD, compared findings acyanotic groups. <i>Methods:</i> Twenty children 23 13 healthy were enrolled. Blood early morning urine samples collected from each subject to measure urinary...
Acute renal failure (ARF) is a major complication in infants who undergo cardiac surgery. The aim of this investigation was to identify possible risk factors for ARF and mortality patients group. Out 64 patients, 21 (32.8%) cases developed acute overall rate 25%. higher the than those did not (66.7% 4.7%, respectively, p < 0.05). Also, positively correlated with (r:0.70, 0.0001). nonsurvivors had lower mean serum albumin survivors (p 0.05), level negatively (r = − 0.34, For 3.5 g/dL,...
Abstract Aim: To examine the relationship between inflammation criteria and body mass index in otherwise‐healthy obese schoolchildren to evaluate effect of obesity on renal functions. Methods: Sixty‐five children (median age 10.8 y, range 7.1–16.5 y; median 26.8 kg/m 2 , 19.9–38.7 ) 20 healthy controls 12.4 10.1–17.1 18.8 17.3–23.1 were included. Blood urine samples taken from every child. Results: Children control groups had similar sex distributions ( p >0.05). Inflammatory mediators...
BackgroundObesity has risen considerably in the Western world and trend is increasing non-Western, developing countries, as well. Several school screening studies showed relation between body mass index hypertension. In adults, obesity associated with an increased risk of development progression kidney disease. However, data at epidemiological level are limited, both for children adults. The aim this study was to determine prevalence evaluate its association hypertension glomerular...
Infantile nephropathic cystinosis is a severe disease that occurs due to mutations in the gene, and it characterized by progressive dysfunction of multiple organs; >100 gene have been identified populations. Our study aimed identify clinical characteristics spectrum Turkish pediatric patients with cystinosis.We multicenter registry was established for data collection. The were extracted from this analyzed.In total, 136 (75 men 61 women) enrolled study. most common findings growth...
Purpose: To report the manifestations, patterns of disease, treatment strategies and outcomes in pediatric patients with noninfectious uveitis.Methods: Demographic information 76 cases was recorded. Symptoms, anatomic location, laterality, visual acuity (VA), intraocular pressure, associated systemic diseases, therapeutic strategies, side effects, complications were reviewed.Results: Thirty-one diagnosed as uveitis on routine surveillance because underlying disease. The most common location...