A5014326898- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Balance, Gait, and Falls Prevention
- Crystallography and molecular interactions
- Pharmaceutical Economics and Policy
- Dialysis and Renal Disease Management
- Advanced Causal Inference Techniques
- Cardiovascular Health and Disease Prevention
- Renal cell carcinoma treatment
- Effects of Vibration on Health
- Liver Disease Diagnosis and Treatment
- Renal function and acid-base balance
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Pediatric Urology and Nephrology Studies
- Stroke Rehabilitation and Recovery
- Advanced Radiotherapy Techniques
- Statistical Methods and Inference
- Renal and Vascular Pathologies
- Bladder and Urothelial Cancer Treatments
- Cerebral Palsy and Movement Disorders
- Sports Science and Education
- Atomic and Subatomic Physics Research
University Hospital Heidelberg
2014-2025
Heidelberg University
2015-2025
Zimmer Biomet (Germany)
2015-2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2018-2024
Heidelberg (Poland)
2021
Agaplesion Bethanien Krankenhaus
2017
University of Edinburgh
2014
Hochschule Fresenius
2013-2014
Goethe University Frankfurt
2012-2013
University of Bradford
1997
Abstract Background Long COVID is defined as the persistence of symptoms beyond 3 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To better understand long-term course and etiology we analyzed a cohort patients with COVID-19 prospectively. Methods Patients were included at 5 in this prospective, noninterventional, follow-up study. followed until 12 symptom onset (n = 96; 32.3% hospitalized, 55.2% females) analysis symptoms, quality life (based on an SF-12...
Multiparametric magnetic resonance imaging has an emerging role in prostate cancer diagnostics. In addition, clinical information is a reliable predictor of significant cancer. We analyzed whether the negative predictive value multiparametric to rule out could be improved using factors, especially specific antigen density.A total 1,040 consecutive men with suspicion underwent first, followed by transperineal systematic and imaging-transrectal ultrasound fusion guided biopsy. Logistic...
Background and objectives Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. Design, setting, participants, & measurements The Comorbidity Children CKD Study a multicenter, prospective, observational study ages 6–17 years old initial GFR of 10–60 ml/min per 1.73 m 2 . cardiovascular status monitored annually, subclinical assessed by noninvasive surrogate markers, including left ventricular mass index, carotid intima-media...
Background and objectives Autosomal dominant polycystic kidney disease is the most common inheritable disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal may develop signs or symptoms during childhood, particular hypertension. Although ambulatory BP monitoring preferred method diagnose hypertension pediatrics, data children are limited. Design, setting, participants, & measurements Our retrospective multicenter study was conducted collect...
Variability indicates motor control disturbances and is suitable to identify gait pathologies. It can be quantified by linear parameters (amplitude estimators) more sophisticated nonlinear methods (structural information). Detrended Fluctuation Analysis (DFA) one method measure structural information, e.g., from stride time series. Recently, an improved method, Adaptive Fractal (AFA), has been proposed. This not applied data before. scaling (FS) require long stride-to-stride obtain valid...
Prevalence of isolated nocturnal hypertension (INH) and daytime (IDH) is around 10% in adults. Data children, especially chronic kidney disease (CKD), are lacking. The aim this cross-sectional multicenter cohort study was to define the prevalence INH IDH its association with cardiovascular morphology function, that is, pulse wave velocity (PWV), carotid intima-media thickness (cIMT), or left ventricular mass index (LVMI) children CKD.Ambulatory blood pressure (BP) monitoring profiles were...
There is no evidence from randomized controlled trials (RCTs) comparing robot-assisted partial nephrectomy (RAPN) and open (OPN).
Objectives To comprehensively compare quality‐of‐life (QoL) outcomes between open partial nephrectomy (OPN) and robot‐assisted PN (RAPN) from the randomised ROBOtic‐assisted versus Conventional Open Partial (ROBOCOP) II trial, as QoL data comparing OPN RAPN are virtually non‐existent, especially not controlled trials (RCTs). Patients Methods The ROBOCOP was a single‐centre, open‐label RCT RAPN. pre‐planned analyses of presented. Data were analysed descriptively in modified intention‐to‐treat...
An assessment is made of the applicability Fourier transform (FT) Raman spectroscopy to analysis ancient human teeth from archaeological sites. Comparisons are between spectra nine modern adult and two exfoliate (deciduous) those eight specimens dating 4th–16th centuries AD. From teeth, complete vibrational assignments proposed for organic proteinaceous inorganic carbonated hydroxyapatite components. Band intensity ratio measurements indicate that collagen component does not change its...
This study investigates the choice of posturographic parameter sets with respect to influence different sampling durations (30 s, 60 300 s). Center pressure (COP) data are derived from 16 healthy subjects standing quietly on a force plate. They were advised focus postural control process ( i.e. internal attention). 33 common linear and 10 nonlinear parameters calculated grouped into five classes. Component structure in each group is obtained via exploratory factor analysis. We demonstrate...
Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level cystatin C-derived estimated glomerular filtration rate (eGFR) assessment of proteinuria spot or timed urine samples, are limited value identifying patients at risk progressive function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 adults.
The uremic toxins indoxyl sulfate (IS) and p-cresyl (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism decline renal excretion. Despite solid experimental evidence for nephrotoxic effects, the impact on progression CKD has not been investigated representative patient cohorts. In this analysis, IS pCS serum concentrations were measured 604 pediatric participants (mean eGFR 27 ± 11 ml/min/1.73m2) at enrolment into prospective...
Abstract Background Setting meaningful, individualized rehabilitation goals is an essential part of the process. Even though patients with dementia are a drastically increasing patient group in geriatric rehabilitation, empirical data about meaningful and collaborative goal-setting this target missing. Cognitive impairment lack insight current deficits have been discussed as barriers for participation goal-setting, but require examination. This study investigated feasibility semi-structured...
Studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations a large sample of CD, and examined the influence sex callous-unemotional (CU) traits.DTI data were acquired from 124 CD (59 female) 174 typically developing (TD) (103 9 18 years age. Tract-based spatial statistics tested for effects diagnosis sex-by-diagnosis interactions. Associations symptoms, CU...
Genetic and environmental factors are involved in the pathogenesis of inflammatory bowel diseases (IBD). The study aimed at investigating potential influence single nucleotide polymorphisms (SNPs) NOD2 rs2066844, rs2066845, rs2066847, IL23R rs11209026, PTPN2 rs2542151, rs7234029, ATG16L1 rs2241880 on response to immunomodulatory therapies disease course Crohn's (CD). This is an uncontrolled retrospective monocentric including patients from IBD outpatient clinic Heidelberg University...
MR neurography demonstrated higher accuracy and sensitivity compared to high-resolution US in diagnosing peripheral neuropathies of the upper extremity, particularly for proximal lesions multi-nerve involvement.
Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre-school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low-intensity, complex NDBI 'Frankfurt Early Intervention Program for ASD' (A-FFIP) over 1 year by a confirmatory phase-III, prospective, randomised, controlled, parallel-group two treatment arms four centres. Main inclusion criteria: ASD (DSM-5), age 24-66 months, quotient >30. Manualised A-FFIP...
Background Immunotherapies targeting the programmed death receptor-1/programmed ligand-1(PD-1/PD-L1) checkpoint have a major impact on treatment of both resectable and advanced non-small cell lung cancer (NSCLC). Additional blockade T-cell immunoreceptor with immunoglobulin tyrosine-based inhibition motif domain (TIGIT)-receptor may synergistically foster immune-related response. Several trials are currently investigating combination neoadjuvant platinum-based chemotherapy dual prior to...
Introduction Adverse events during paediatric anaesthesia are common, with hypoxaemia the induction period being a leading cause, as infants and children particularly vulnerable to periods of apnoea. The administration supplementary oxygen, referred apnoeic oxygenation, has been shown prolong safe apnoea times increase first-pass intubation success rates. Despite these benefits, oxygenation is not routinely used in anaesthesia. Low-flow delivered via standard nasal cannula, simple approach...