A5071743057- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Treatments and Mutations
- Sepsis Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Myasthenia Gravis and Thymoma
- Management of metastatic bone disease
- Cardiac and Coronary Surgery Techniques
- Radiopharmaceutical Chemistry and Applications
- Hip and Femur Fractures
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Cancer therapeutics and mechanisms
- Radiomics and Machine Learning in Medical Imaging
National Center for Tumor Diseases
2025
University of Duisburg-Essen
2025
Ruhrlandklinik
2023-2025
University Hospital Cologne
2017-2023
University of Cologne
2014-2022
Lungenklinik Köln-Merheim
2017-2021
Centrum für Integrierte Onkologie
2017-2021
Klinik und Poliklinik für Neurologie
2017
Friedrich Schiller University Jena
2010-2014
Jena University Hospital
2011
Abstract The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown 1–3 . Here we determined tumour phylogenies at diagnosis throughout immunotherapy by multiregion sequencing 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity distinct sites, whereas first-line platinum-based led a burst in genomic intratumour heterogeneity spatial diversity. We observed branched evolution shift...
Abstract Background Outcome prediction scoring systems are increasingly used in intensive care medicine, but most were not developed for use cardiac surgery patients. We compared the performance of four outcome (Acute Physiology and Chronic Health Evaluation II [APACHE II], Simplified Acute Score [SAPS Sequential Organ Failure Assessment [SOFA], Cardiac Surgery [CASUS]) patients after open heart surgery. Methods prospectively included all consecutive adult who underwent admitted to unit...
Abstract Small cell lung cancer (SCLC) is a difficult to treat subtype of cancer. One the hallmarks SCLC its almost uniform chemotherapy sensitivity. However, response typically transient and patients frequently succumb within year following diagnosis. We performed transcriptome analysis major human entities. show significant overexpression genes involved in DNA damage response, specifically SCLC. Particularly CHEK1 , which encodes for cycle checkpoint kinase CHK1, significantly...
<b>Background</b> Our purpose was to evaluate and compare the accuracy of "Sequential Organ Failure Assessment" score (SOFA) "Cardiac Surgery Score" (CASUS) for prediction mortality after cardiac surgery. <b>Methods</b> Between January 1, 2007 December 31, 2008 we prospectively included all consecutive adult patients admitted our intensive care unit (ICU) Both scoring systems were calculated daily from 1st day in ICU (day operation) until 7th day. We evaluated both models using calibration...
Surgical expertise is crucial in determining resectability. Due to differences surgical expertise, cooperation with other departments, and technical equipment available, a differentiation between "standard resectability" "resectability advanced requirements" can introduce clear decision algorithm for interdisciplinary tumorboards. The current 2024 EORTC survey highlights areas lack of consensus on indications stage III NSCLC. T4 NSCLC involvement adjacent structures should be managed...
The purpose of this study was to develop a specific postoperative score in intensive care unit (ICU) cardiac surgical patients for the assessment organ dysfunction and survival. To prove reliability new scoring system, we compared its performance existing ICU scores.This prospective consisted all consecutive adult admitted after surgery our over period 5.5 years. Variables were evaluated using first year who stayed at least 24h. reproducibility then tested two validation sets patients....
<b>Background</b> Blood lactate is accepted as a mortality risk marker in intensive care units (ICUs), especially after cardiac surgery. Unfortunately, most of the commonly used ICU stratification scoring systems did not include blood variable. We hypothesized that alone can predict surgery with an accuracy comparable to those other complex models. therefore evaluated its at prediction and compared it widely models statistically. <b>Methods</b> prospectively collected data all consecutive...
Objectives: Classifying radiologic pulmonary lesions as malignant is challenging. Scoring systems like the Mayo model lack precision in predicting probability of malignancy. We developed logistic scoring system ‘LIONS PREY’ (Lung lesION Score PREdicts malignancY), which superior to existing models its determining likelihood Methods: evaluated all patients that were presented our multidisciplinary team between January 2013 and December 2020. Availability pathological results after resection...
Expression of BCL-B, an anti-apoptotic BCL-2 family member, is correlated with worse survival in lung adenocarcinomas. Here, we show that BCL-B can mitigate cell death initiation through interaction the effector protein BOK. We found this promote sublethal mitochondrial outer membrane permeabilization (MOMP) and consequently generate apoptosis-flatliners, which represent a source drug-tolerant persister cells (DTPs). The engagement endothelial-mesenchymal-transition (EMT) further promotes...
Objectives: While the treatment of non-small-cell lung carcinoma has improved rapidly, pulmonary large-cell neuroendocrine (LCNEC) remains underdeveloped. The use immunohistochemistry allows for accurate risk stratification. With our study, we investigated outcome patients with LCNEC and analyzed whether CK7 correlates long-term survival. Methods: We retrospectively collected monocentric data which underwent anatomical resection cancer between January 2012 December 2020. Patients that did...
Introduction: Nodal involvement is one of the most important prognostic factors in NSCLC. Skip-N2 metastasis (N0N2), which N2 absence N1 metastasis, occurs approximately 20–30% patients. According to International Association for Study Lung Cancer, and N0N2 patients may have comparable long-term survival, considering their similar tumor stages. However, this conclusion remains controversial. Therefore, we carried out multicenter study examine survival disease-free interval (DFI) N0N2-...
Background Immunotherapies targeting the programmed death receptor-1/programmed ligand-1(PD-1/PD-L1) checkpoint have a major impact on treatment of both resectable and advanced non-small cell lung cancer (NSCLC). Additional blockade T-cell immunoreceptor with immunoglobulin tyrosine-based inhibition motif domain (TIGIT)-receptor may synergistically foster immune-related response. Several trials are currently investigating combination neoadjuvant platinum-based chemotherapy dual prior to...
Abstract Background The original Logistic Organ Dysfunction Sore (LODS) excluded cardiac surgery patients from its target population, and the suitability of this score in has never been tested. We evaluated accuracy LODS usefulness daily measurement patients. is not a true logistic scoring system, since it does use β-coefficients. Methods This prospective study included all consecutive adult who were admitted to intensive care unit (ICU) after between January 2007 December 2008. was...
Myasthenia gravis (MG) is a rare neuromuscular disorder. Symptoms can range from ptosis only to life threatening myasthenic crisis. Thymectomy recommended for anti-acetylcholine receptor-antibody positive patients with early-onset MG. Here, we investigated prognostic factors shaping therapeutic outcomes of thymectomy improve patient stratification.We retrospectively collected single-center data specialized center MG all consecutive adult that underwent 01/2012 12/2020. We selected...
Abstract Background The prolonged air leak is probably the most common complication following lung resections. Around 10–20% of patients who undergo a resection will eventually develop leak. definition varies between an leak, which evident after fifth, seventh or even tenth postoperative day to every that prolongs hospital stay. However, stay thoracoscopic lobectomy can be as short 2 days, making above definitions sound outdated. treatment these leaks also very versatile. One broadly...
Objectives: About 90% of all non-small cell lung cancer (NSCLC) cases are associated with inhalative tabacco smoking. Half patients continue smoking during therapy. We examined the effects postoperative cessation on function, quality life (QOL) and long-term survival. Materials Methods: In total, 641 patients, who underwent lobectomy between 2012 2019, were identified from our single institutional data base. Postoperatively, that actively smoked at time operation offered a structured...
BACKGROUND We hypothesized that the combination of a preoperative and postoperative scoring system would improve accuracy mortality prediction therefore combined 'additive EuroSCORE' (European for cardiac operative risk evaluation) with CASUS' (Cardiac Surgery Score) to form 'modified CASUS'. MATERIAL AND METHODS included all consecutive adult patients after surgery during January 2007 December 2010 in our prospective study. Our single-centre study was conducted German general referral...