A5055479708- Sarcoma Diagnosis and Treatment
- Cancer survivorship and care
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Palliative Care and End-of-Life Issues
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- Clinical practice guidelines implementation
- Management of metastatic bone disease
- Gastrointestinal Tumor Research and Treatment
- Renal and Vascular Pathologies
- Health and Medical Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Treatments and Studies
European Neuroendocrine Tumor Society
2025
Technische Universität Dresden
2013-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2014-2024
University Hospital Carl Gustav Carus
2015-2024
Stiftung Oskar Helene Heim
2021-2024
Center for HIV and Hepatogastroenterology
2021-2024
University of Southern California
2024
Praxis für Hämatologie und Onkologie
2022
National Center for Tumor Diseases
2021
Charité - Universitätsmedizin Berlin
2021
PURPOSE Doxorubicin is a standard of care in patients with advanced, inoperable soft tissue sarcoma (STS). We tested whether pazopanib has efficacy comparable to that doxorubicin elderly STS and offers superior tolerability for hematologic toxicity. PATIENTS AND METHODS Patients age 60 years or older without previous systemic treatment progressive advanced metastatic who had Eastern Cooperative Oncology Group performance status 0 2 adequate organ function were included. Treatment consisted...
Sarcomas are rare cancers with high heterogeneity in terms of type, location, and treatment. The health-related quality life (HRQoL) sarcoma patients has rarely been investigated is the subject this analysis. Adult survivors were assessed between September 2017 February 2019 39 study centers Germany using standardized, validated questionnaires (European Organization for Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ-C30)). Associated factors analyzed exploratively...
<b><i>Objective:</i></b> Epithelioid sarcoma (ES) presents unique clinical features in comparison to other subtypes. Data regarding the benefits of chemotherapy are very limited. Combination regimens using gemcitabine and docetaxel (Gem/Doce) have proven be effective, especially uterine nonuterine leiomyosarcoma. Yet, there is no available data on efficacy Gem/Doce ES. <b><i>Methods:</i></b> A retrospective analysis three participating...
In this paper, we present Animal, a new tool for developing animations to be used in lectures. Animal offers small but powerful set of graphical operators. Animations are generated using visual editor, by scripting or via API calls. All can edited visually. supports source and pseudo code inclusion highlighting as well precise user-defined delays between actions. The paper evaluates the functionality comparison other animation tools.
Introduction: The impact of being diagnosed with a life-threatening illness may influence preferences to participate in treatment decisions. objective this analysis was identify factors that are associated sarcoma patients wanting take more active or passive role. Methods: Data obtained as part nationwide multicenter study (PROSa) aiming investigate the structure and quality medical care Germany their determinants. conducted between 2017 2020 39 centers. For present analysis, cross-sectional...
Cancer patients have been shown to frequently suffer from financial burden before, during, and after treatment. However, the toxicity of with sarcoma has seldom assessed. Therefore, aim this study was evaluate whether is a problem for in Germany identify associated risk factors.Patients analysis were obtained multicenter prospective cohort conducted Germany. Using difficulties scale EORTC QLQ-C30, considered be present if score exceeded pre-defined threshold clinical importance. Comparisons...
E-TRAB was a non-interventional, prospective trial investigating the feasibility and predictive value of geriatric assessments (GA) in older STS patients treated with trabectedin as first-line therapy. Primary endpoints were overall survival (OS), quality life individual clinical benefit assessed by patient-reported outcome measures QLQ-C30 PRO-CTCAE. Further, several GA tools applied correlated outcomes treatment-related toxicities. The final analyses included 69 from 12 German-speaking...
Abstract Background Sarcomas are rare cancers of high heterogeneity. Health-Related Quality Life (HRQoL) has been shown to be a prognostic factor for survival in other cancer entities but it is unclear whether this applies sarcoma patients. Patients and methods HRQoL was prospectively assessed adult patients from 2017 2020 39 German recruiting sites using the European Organisation Research Treatment Cancer Questionnaire (EORTC QLQ-C30). Vital status ascertained over course 1 year. domains...
Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a new whole-body hybrid PET/MR technique that combines metabolic cross-sectional diagnostic imaging. Since the use of MRI in soft-tissue sarcoma extremely beneficial, investigation combined PET/MRI great interest. In this paper, we present three cases first data. Combined can support process clinical decision-making give answers to some meaningful questions when treating patients with STS. Therefore,...
<b><i>Background:</i></b> The aim of this study was to identify an appropriate screening instrument for the identification frail elderly patients in a tertiary cancer center. In order improve care older patients, use geriatric assessment (GA) has been proposed or those who are at higher risk chemotherapy-related toxicities. busy clinical routine, could be used spare time- and resource-consuming application GA. <b><i>Patients Methods:</i></b> We...
It has been demonstrated that physical exercise benefits younger patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT). We designed a prospective pilot study investigating whether elderly (>60 years) would also be able to participate in such programme. consisted of physiotherapist-supervised alternating endurance and resistance workouts on 6 7 days week. Sixteen consecutive allo-HSCT were enrolled into the study. The median age was 64.5 years. Twelve...
Anthracyclines, as the most effective therapy, are cornerstone of advanced stage sarcoma treatment. However, anthracyclines can also contribute to myocardial dysfunction and congestive heart failure, ultimately limiting therapeutic potential drug. Coadministration Dexrazoxane has been shown effectively reduce cardiotoxicity, however primarily in patients suffering diseases other than sarcoma.The aim this retrospective analysis was evaluate safety efficacy chemotherapy with high cumulative...
Introduction Sarcomas are rare cancers and very heterogeneous in their location, histological subtype, treatment. Health-Related Quality of Life (HRQoL) sarcoma patients has rarely been investigated longitudinal studies. Methods Here, we assessed adult survivors between September 2017 February 2020, followed-up for one year 39 study centers Germany. Follow-up time points were 6 (t1) 12 months (t2) after inclusion. We used a standardized, validated questionnaire (the European Organisation...
We sought to examine whether mitotic count (MC) and the amount of viable tumour (VT) following neoadjuvant systemic chemotherapy (SC) for primary, localised, high-grade soft tissue sarcoma (STS) correlate with prognosis. Retrospective analysis 57 patients who underwent SC involving a combination an anthracycline alkylating agent, followed by surgical resection between 2001 2011. The VT after was significantly associated disease-specific survival (DSS) event-free (EFS). Patients <10% had DSS...
<b><i>Background:</i></b> Data on institutional structures of sarcoma care in Germany are scarce. The utilization an interdisciplinary tumor board (IDTB) is essential part modern cancer care. We investigated to which extent and when IDTB used hypothesized that before treatment initiation were more often at certified centers high-volume increased over time. <b><i>Methods:</i></b> From 2017 2020 we conducted a prospective cohort study,...