A5077109548- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Clinical practice guidelines implementation
- MRI in cancer diagnosis
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Health and Medical Research Impacts
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Lymphatic System and Diseases
- Meta-analysis and systematic reviews
- Advanced X-ray and CT Imaging
- Colorectal Cancer Surgical Treatments
- Ureteral procedures and complications
- Chronic Lymphocytic Leukemia Research
University Medical Centre Mannheim
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
University Hospital and Clinics
2025
University Medical Center
2025
German Cancer Research Center
2024
Klinik und Poliklinik für Urologie
2023
Medizinische Fakultät Mannheim
2016-2021
Czech Academy of Sciences, Institute of Psychology
2021
Urologische Klinik München
2021
Radiomics is an emerging field of image analysis with potential applications in patient risk stratification. This study developed and evaluated machine learning models using quantitative radiomic features extracted from multiparametric magnetic resonance imaging (mpMRI) to detect classify prostate cancer (PCa). In total, 191 patients that underwent prostatic mpMRI combined targeted systematic fusion biopsy were retrospectively included. Segmentations the whole glands index lesions performed...
Extracellular vesicles (EVs) are shed by many different cell types. Their nucleic acids content offers new opportunities for biomarker research in solid tumors. The role of EV RNA prostate cancer (PCa) is still largely unknown. EVs were isolated from benign and malignant lines blood plasma patients with PCa (n = 18) controls prostatic hyperplasia (BPH) 7). Nanoparticle tracking analysis (NTA), Western blot, electron microscopy, flow cytometry used the characterization EVs. Non-coding...
There is no evidence from randomized controlled trials (RCTs) comparing robot-assisted partial nephrectomy (RAPN) and open (OPN).
Objectives To comprehensively compare quality‐of‐life (QoL) outcomes between open partial nephrectomy (OPN) and robot‐assisted PN (RAPN) from the randomised ROBOtic‐assisted versus Conventional Open Partial (ROBOCOP) II trial, as QoL data comparing OPN RAPN are virtually non‐existent, especially not controlled trials (RCTs). Patients Methods The ROBOCOP was a single‐centre, open‐label RCT RAPN. pre‐planned analyses of presented. Data were analysed descriptively in modified intention‐to‐treat...
Chronic kidney disease (CKD) affects over 10% of the global population, amounting to more than 800 million individuals worldwide. The advances in treatment CKD have had a significant impact on patient outcomes. While past, was often considered death sentence, with many patients succumbing complications end-stage renal disease, it is now increasingly being managed as chronic condition availability dialysis and transplantation, well new pharmaceutical developments such SGLT2 inhibitors or...
Focal therapies (FTs) are investigated within prospective studies on selected patients treated for localized prostate cancer (PCa). Benefits preservation of genitourinary function and reduced complications, but follow-up is elaborate associated with uncertainty as cancer-free survival appears to be lower compared standard radical treatments. The aim this study was analyse patient-reported acceptance FT evaluate factors treatment decision regret.
To report feasibility and outcome of salvage robotic-assisted laparoscopic radical prostatectomy (S-RALP) after focal therapy using high-intensity focused ultrasound (HIFU) treatment compared to primary (pRALP).In this bicentric trial patients undergoing S-RALP for detection WHO2016/ISUP Grade Group 2 or 3 prostate cancer were previously treated in prospective HIFU trials. Perioperative data, complications, oncological functional analysed. Patients who underwent pRALP matched a ratio...
To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC).Male patients who received docetaxel at a tertiary university care center between 2014 2019 were screened completion of 6 cycles. NLR, SII, mGPS, overall survival...
Abstract Background Data from interventional studies suggest that a peritoneal flap after pelvic lymph node dissection (LND) during laparoscopic, robotic-assisted radical prostatectomy (RARP) may reduce the rate of symptomatic lymphoceles in transperitoneal approach. However, most these are not conducted randomized controlled fashion, thus limiting their scientific value. A recent prospective, randomized, trial (RCT) did show superiority while further trials lacking. Therefore, aim presented...
Advances in therapy of metastatic castration-refractory prostate cancer (mCRPC) resulted more therapeutic options and led to a higher need predictive/prognostic biomarkers. Systemic inflammatory biomarkers could provide the basis for personalized treatment selection. This study aimed assess modified Glasgow Prognostic Score (mGPS), neutrophile-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) systemic immune-inflammation index (SII) men with mCRPC under docetaxel.Patients taxane...
To compare severe infectious complication rates after transrectal prostate biopsies between cephalosporins and fluoroquinolones for antibiotic monoprophylaxis.In the multi-institutional cohort, November 2014 July 2020 patients received either cefotaxime (single dose intravenously), cefpodoxime (multiple doses orally) or (multiple-doses orally single intravenously) biopsy prophylaxis. Data were prospectively acquired retrospectively analyzed. Severe complications evaluated within 30 days...
The purpose of this study was to evaluate the outcomes performing 2 consecutive open radical cystectomies (RCs) within 1 day by same surgical team. A retrospective analysis conducted on data from patients who underwent RC at a single tertiary care center January 2015 February 2023. Patient characteristics, perioperative and endpoints were analyzed. Univariable multivariable logistic regression models created predict major complications. total 657 included in final cohort, containing 64...