The aims of this study were to assess diagnostic accuracy diffusion tensor imaging (DTI) in chronic inflammatory demyelinating polyneuropathy (CIDP), correlate DTI with electrophysiological parameters, and evaluate whether radial diffusivity (RD) axial (AD) might serve as specific biomarkers axonal pathology.This prospective was approved by the institutional ethics committee, written informed consent obtained from all participants. Magnetic resonance neurography upper lower extremity nerves...

To evaluate functional and morphometric magnetic resonance neurography of the dorsal root ganglion peripheral nerve segments in patients with Fabry painful neuropathy.In this prospective study, lumbosacral ganglia proximal lower extremity were examined 11 male disease by a standardized 3T protocol. Volumes L3 to S2 ganglia, perfusion parameters L5-S1 spinal L5, cross-sectional area sciatic compared healthy controls.Dorsal symmetrically enlarged 78% (L3), 94% (L4), 122% (L5), 115% (S1), 119%...

To develop an in-vivo imaging method for the measurement of dorsal-root-ganglia-(DRG) perfusion, to establish its normal values in patients without known peripheral nerve disorders or radicular pain syndromes and determine physiological spatial perfusion pattern within DRG.This prospective study was approved by institutional ethics committee written informed consent obtained from all participants. 46 (24 female, 22 male, mean age 46.0±15.2years) subjects neuropathies were examined a 3Tesla...

MR neurography demonstrated higher accuracy and sensitivity compared to high-resolution US in diagnosing peripheral neuropathies of the upper extremity, particularly for proximal lesions multi-nerve involvement.

To investigate in vivo morphological and functional correlates of oxaliplatin-induced peripheral neuropathy (OXA-PNP) by magnetic resonance neurography (MRN).Twenty patients (7 female, 13 male, 58.9±10.0 years) with mild to moderate OXA-PNP 20 matched controls (8 12 55.7±15.6 were prospectively enrolled. All underwent a detailed neurophysiological examination prior neuroimaging. A standardized imaging protocol at 3.0 Tesla included the lumbosacral plexus both sciatic nerves their branches...

Background Differential diagnosis between amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN) relies on clinical examination electrophysiological criteria. Peripheral nerve imaging might assist this differential diagnosis. Purpose To assess diagnostic accuracy of MR neurography in the ALS MMN. Materials Methods This prospective study was conducted December 2015 April 2017. Study participants with or MMN underwent lumbosacral plexus, midthigh, proximal calf, midupper arm...

Background Diffusion-weighted imaging (DWI) provides specific in vivo information about tissue microstructure, which is increasingly recognized for various applications outside the central nervous system. However, standard sequence parameters are commonly adopted from optimized system protocols, thus potentially neglecting differences tissue-specific diffusional behavior. Purpose To characterize optimal diffusion weighting scheme over b domain peripheral nerves under physiologic and...

The aim of this study was to assess the imaging appearance and diagnostic value plexus peripheral nerve magnetic resonance neurography (MRN) in cervical radiculopathy.This prospective approved by our institutional ethics committee written informed consent obtained from all participants. A total 24 patients were included with a diagnosis radiculopathy based on clinical examination, supporting electrophysiological examinations spinal consistent syndrome. All then underwent high-resolution MRN...

The clinical phenotype associated with germline SMARCB1 mutations has as yet not been fully documented. It is known that may cause rhabdoid tumor predisposition syndrome (RTPS1) or schwannomatosis. However, the co-occurrence of and schwannomas in same patient so far reported.

Schwannomatosis and neurofibromatosis type 2 are hereditary tumor syndromes, peripheral neuropathy has been reported in both. We prospectively applied vivo morphometric measurement of dorsal root ganglia volume 16 schwannomatosis patients, 14 26 healthy controls by magnetic resonance neurography. Compared to controls, hypertrophy was a consistent finding (L3, + 267%; L4, 235%; L5, 241%; S1, 300%; S2, 242%; Bonferroni-adjusted p < 0.001) but not schwannomatosis. Dorsal may be vulnerable site...

<h3>Objective</h3> To examine the involvement of dorsal root ganglia and peripheral nerves in children with neurofibromatosis type 2 compared to healthy controls symptomatic adults by vivo high-resolution magnetic resonance neurography. <h3>Methods</h3> In this prospective multicenter study, lumbosacral sciatic, tibial, peroneal were examined 9 polyneuropathy-negative diagnosed a standardized neurography protocol at 3T. Volumes L3 S2 nerve lesions assessed those 29 children. Moreover,...

By applying diffusor tensor imaging (DTI) in patients with anterior interosseous nerve syndrome (AINS), this proof of principle study aims to quantify the extent structural damage a peripheral at anatomical level individual fascicles. In institutional review board approved prospective 13 spontaneous AINS were examined 3 Tesla including transversal T2-weighted turbo-spin-echo and spin-echo echo-planar-imaging pulse sequence upper arm level. Calculations quantitative DTI parameters fractional...

Zusammenfassung Einleitung Die korrekte Diagnose und Lokalisation von peripheren Nervenläsionen ist essentiell für die Wahl der richtigen Therapie in Nervenchirurgie. Vor allem Substanzdefekte müssen erkannt werden um eine frühe Wiederherstellung zu ermöglichen Langzeitschäden verhindern. Neueste Entwicklungen MR-Neurographie können detaillierte Informationen über Morphologie zukünftig möglicherweise sogar Funktionalität eines Nervs Relation umgebenden Strukturen liefern. In dieser Fallserie...

To assess the correlation of peripheral nerve and skeletal muscle magnetization transfer ratio (MTR) with demographic variables. In this study 59 healthy adults evenly distributed across 6 decades (mean age 50.5 years ±17.1, 29 women) underwent imaging high-resolution T2-weighted sciatic at 3 T. Mean MTR as well biceps femoris vastus lateralis muscles were calculated based on manual segmentation six representative slices. Correlations age, body height, weight, mass index (BMI) expressed by...

The pathophysiological significance of the Fabry-related, non-classical variant p.D313Y still remains to be solved. This study assesses involvement peripheral nervous system with respect small fiber neuropathy and neuropathic pain in female patients carrying p.D313Y.This examined nine females Fabry-related by obtaining skin punch biopsies above right lateral malleolus. Intraepidermal nerve density was determined for each patient compared reference values matched patient's decade life sex....

The purpose of this study is to examine alterations the peripheral nervous system (PNS) in oligo-symptomatic patients carrying Fabry related GLA-gene variant p.A143T by Magnetic Resonance Neurography (MRN) and skin biopsy. This prospective assessed dorsal root ganglia (DRG) volume L3 S2, vascular permeability DRG L5, S1, spinal nerve L5 five comparison with classical mutations healthy controls. Moreover, punch biopsies above lateral malleolus right foot were obtained four intraepidermal...

Quantitative MR-neurography (MRN) is increasingly applied, however, the impact of MR-scanner on derived parameters unknown. Here, we used different 3.0T MR scanners and applied comparable MR-sequences in order to quantify inter-scanner reproducibility various MRN sciatic nerve.Ten healthy volunteers were prospectively examined at three underwent their nerve using imaging protocols including diffusion tensor (DTI) T2 relaxometry. Subsequently, agreement was assessed for seven by calculating...

Background: Dorsal root ganglia (DRG) volume assessment by MR-Neurography (MRN) has evolved to an important imaging marker in the diagnostic workup of various peripheral neuropathies and pain syndromes. The aim this study was (1) assess normal values DRG correlations with demographic determinants (2) quantify inter-reader inter-method reliability three different methods volumetry. Methods: Sixty healthy subjects (mean age: 59.1, range 23-79) were examined using a 3D T2-weighted MRN...