A5006182693- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- Antioxidant Activity and Oxidative Stress
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Algal biology and biofuel production
- Dialysis and Renal Disease Management
- Celiac Disease Research and Management
- Microencapsulation and Drying Processes
- Central Venous Catheters and Hemodialysis
- Proteins in Food Systems
- Phytochemicals and Antioxidant Activities
- Vascular Procedures and Complications
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Phase Change Materials Research
- Frailty in Older Adults
- Catalysts for Methane Reforming
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Parathyroid Disorders and Treatments
- Adsorption and Cooling Systems
- Acute Kidney Injury Research
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017-2025
Columbia University
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Columbia University Irving Medical Center
2020-2024
University of Pennsylvania
2021-2024
Ospedale Maggiore
2019-2024
New York University
2024
Sorbonne Université
2022
University of Verona
2016-2020
The green alga Chlamydomonas reinhardtii does not synthesize high-value ketocarotenoids like canthaxanthin and astaxanthin; however, a β-carotene ketolase (CrBKT) can be found in its genome. CrBKT is poorly expressed, contains long C-terminal extension homologues likely represents pseudogene this alga. Here, we used synthetic redesign of gene to enable constitutive overexpression from the nuclear genome C. reinhardtii. Overexpression optimized extended native carotenoid biosynthesis generate...
Addition of different types phase change materials (PCMs) to cement-based for thermal energy storage has been broadly investigated in the literature. Many studies have researched addition organic PCMs and performance PCM-cement system. However, drawbacks such as leakage poor conductivity stimulated improve properties within Among solutions, carbonous (such graphite carbon nanotubes) investigated. In current work, an innovative system that contains microencapsulated (MPCMs) purposely...
Background Frailty is common in older patients affected by chronic kidney disease (CKD). Since gut microbiota (gMB) may contribute to frailty, we explored possible associations between gMB and frailty CKD. Methods We studied 64 CKD (stage 3b-4), categorized as frail (F, 38) not (NF, 26) according Fried criteria, 15 controls (C), all than 65 years. In assessed serum C-reactive protein, blood neutrophil/lymphocyte ratio, Malnutrition-inflammation Score (MIS); was denaturing gel gradient...
Abstract Chronic Kidney Disease (CKD) represents a slowly progressive disorder that is typically silent until late stages, but early intervention can significantly delay its progression. We designed portable and scalable electronic CKD phenotype to facilitate disease recognition empower large-scale observational genetic studies of kidney traits. The algorithm uses combination rule-based machine-learning methods automatically place patients on the staging grid albuminuria by glomerular...
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome is involved in susceptibility pathogens, celiac disease, inflammatory bowel IgA nephropathy. We performed a genome-wide association study of serum levels 41,263 individuals diverse ancestries identified 20 significant loci, including 9 known 11 novel loci. Co-localization analyses with expression QTLs prioritized candidate genes for 14 Most loci encoded that produced immune defects abnormalities...
Astaxanthin (ASX) is a carotenoid of great interest due to its potential health benefits. However, use in the food, feed, and pharmaceutical fields limited low bioavailability, poor stability during thermochemical treatments, susceptibility oxidation, organoleptic characteristics. The aim this work was develop method stabilize astaxanthin extracted from microalgae Haematococcus pluvialis (H.p.) improve nutritional functional properties through nanoencapsulation. Nanoparticles (NPs) were...
Sarcopenia is a prevalent condition in chronic kidney disease (CKD). We determined gut microbiota (gMB) composition CKD patients with or without sarcopenia. Furthermore, we investigated whether these patients, there was any association between gMB, uremic toxins, inflammation and oxidative stress. analyzed gMB composition, toxins (indoxyl sulphate p-cresyl sulphate), inflammatory cytokines (interleukin 10, tumor necrosis factor α, interleukin 6, 17, 12 p70, monocyte chemoattractant protein-1...
Summary Astaxanthin (ASX) is a carotenoid characterised by numerous health‐promoting properties but biased scarce chemical stability. Our aim was to microencapsulate ASX through ionic gelation improve its stability and bioaccessibility, evaluating the performance of low‐methoxyl pectin (LMP) chitosan, besides most common alginate. Three formulations were tested: 3% (Pec), + chitosan shell (PecChi) 1.5% alginate—1.5% LMP shell. The results showed that deposited onto PecAlChi PecChi beads...
Significance Statement Vesicoureteral reflux (VUR) is associated with progressive kidney disease. Familial aggregation supports a hereditary basis; however, its genetic architecture remains to be elucidated. The largest VUR copy number variant analysis and genome-wide association study date accounts for multiple modes of inheritance sex-specific effects in VUR, identifying three study-wide significant five suggestive loci large effects, containing canonical developmental genes including...
BACKGROUNDIt is unknown whether the risk of kidney disease progression and failure differs between patients with without genetic disorders.METHODSThree cohorts were evaluated: prospective Cure Glomerulonephropathy Network (CureGN) 2 retrospective from Columbia University, including 5,727 adults children any etiology who underwent whole-genome or exome sequencing. The effects monogenic disorders APOL1 kidney-risk genotypes on failure, estimated glomerular filtration rate (eGFR) decline,...
Background: A family history of health conditions may reflect shared genetic and/or environmental risk. It is not well known to what extent impacts outcomes among patients with chronic kidney disease (CKD). Herein, we studied the associations CKD, diabetes, and other common comorbidities progression CKD. Methods: We carried out an observational study two prospective CKD cohorts, 2,573 adults children from Cure Glomerulopathy Network (CureGN) 3,939 Chronic Renal Insufficiency Cohort (CRIC)...
Central venous catheter use is rising in chronic and acute hemodialysis. Catheter-related bloodstream infections are a major complication of central use. This article examines clinical factors associated with catheter-related incidence.In this retrospective, single-center study, 413 patients undergoing extracorporeal treatments between 1 February 2014 31 January 2017 560 catheters were recruited. Clinical parameters, such as gender, age, kidney disease status, diabetes, immunosuppression,...