Danielle E. Soranno
A5066720542- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Mechanical Circulatory Support Devices
- Diversity and Career in Medicine
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Biomedical Research and Pathophysiology
- Renal function and acid-base balance
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Adolescent and Pediatric Healthcare
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Alkaline Phosphatase Research Studies
- Trauma and Emergency Care Studies
Indiana University School of Medicine
2022-2025
Purdue University West Lafayette
2023-2025
Riley Hospital for Children
2022-2025
Indiana University – Purdue University Indianapolis
2022-2025
Indiana University
2023-2025
Indiana University Health
2024
Colorado Kidney Care
2024
Children's Hospital Colorado
2015-2023
University of Colorado Denver
2014-2023
Baylor College of Medicine
2023
Importance Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults is associated with poor short-term long-term outcomes. Guidance required to focus efforts related expansion of pediatric AKI knowledge. Objective To develop expert-driven specific recommendations on needed research, education, practice, advocacy. Evidence Review At the 26th Acute Disease Quality Initiative meeting conducted November 2021 by 47 multiprofessional international...
OBJECTIVES: With the recognition that fluid overload (FO) has a detrimental impact on critically ill children, critical care nephrology community focused identifying clinically meaningful targets for intervention. The current study aims to evaluate epidemiology and outcomes associated with FO in an international multicenter cohort of children. also association at predetermined relevant thresholds time points (FO ≥ 5% 10% end ICU days 1 2) outcomes. DESIGN: Prospective study. SETTING:...
Importance Kidney disease is common in infants admitted to the neonatal intensive care unit (NICU). Despite risk of chronic kidney (CKD) discharged from NICU, neither evidence- nor expert-based recommendations exist guide clinical after discharge. Objective To develop for stratification and health monitoring among discharge NICU. Evidence Review At National Institute Health–supported Consensus Workshop Address Health Neonatal Intensive Care Unit Graduates meeting conducted February 2024, a...
Importance Continuous kidney replacement therapy (CKRT) is increasingly used in youths with critical illness, but little known about longer-term outcomes, such as persistent dysfunction, continued need for dialysis, or death. Objective To characterize the incidence and risk factors, including liberation patterns, associated major adverse events 90 days after CKRT initiation (MAKE-90) children, adolescents, young adults. Design, Setting, Participants This international, multicenter cohort...
Sex differences exist in acute kidney injury (AKI), and the role that sex gender play along AKI care continuum remains unclear. The 33rd Acute Disease Quality Initiative meeting evaluated available data on of identified knowledge gaps. Data from experimental models, pathophysiology, epidemiology, clinical care, gender, social determinants health, education, advocacy were reviewed. Recommendations include incorporating into research bench-to-bedside spectrum, analyzing sex-stratified results,...
Abstract Shear‐thinning hydrogels are useful in numerous applications, including as injectable carriers that act scaffolds to support cell and drug therapies. Here, we describe the engineering of a self‐assembling Dock‐and‐Lock (DnL) system forms shear‐thinning using molecular recognition interactions also possess photo‐triggerable secondary crosslinks. These DnL fabricated from peptide‐modified hyaluronic acid (HA) polypeptide precursors, can self‐heal immediately after shear induced flow,...
Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small single center in design. Large international studies evaluating practice outcomes lacking. Herein, we describe design a multinational collaborative.
Importance The incidence and associated outcomes of recurrent acute kidney injury (rAKI) in neonates remain largely unknown. Objective To determine the incidence, risk factors, clinical with rAKI critically ill neonates. Design, Setting, Participants This cohort study was a secondary analysis multicenter, international Assessment Worldwide Acute Kidney Injury Epidemiology Neonates retrospective study. Comparisons were made among no AKI, single AKI episode (sAKI), rAKI. All younger than 14...
Injectable hydrogels can be used to deliver drugs in situ over a sustained period of time. We hypothesized that delivery interleukin-10 (IL-10) following acute kidney injury (AKI) would mitigate the local and systemic proinflammatory cascade induced by AKI reduce subsequent fibrosis. Wild-type C57BL/6 mice underwent ischemia-reperfusion with avertin anesthesia. Three days later, were treated either hyaluronic acid injectable hydrogel or without IL-10, IL-10 suspended saline, injected under...
Neutrophil gelatinase associated lipocalin (NGAL, Lcn2) is the most widely studied biomarker of acute kidney injury (AKI). Previous studies have demonstrated that NGAL produced by and released into urine plasma. Consequently, currently considered a tubule specific marker AKI. However, utility to predict AKI has been variable suggesting other mechanisms production are present. IL-6 proinflammatory cytokine increased in plasma two hours mediates distant organ effects. Herein, we investigated...