A5073872383- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Central Venous Catheters and Hemodialysis
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Health and Biochemistry
- Poisoning and overdose treatments
- Renal Diseases and Glomerulopathies
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Renal and related cancers
- Biomedical Research and Pathophysiology
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Electrolyte and hormonal disorders
- Congenital Anomalies and Fetal Surgery
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Genetic and Kidney Cyst Diseases
- Fetal and Pediatric Neurological Disorders
- Mechanical Circulatory Support Devices
- Methemoglobinemia and Tumor Lysis Syndrome
- Renal function and acid-base balance
University of Washington
2014-2024
Seattle Children's Hospital
2013-2024
Seattle University
2004-2021
Pediatrics and Genetics
2017
University of California, San Francisco
2017
Social Research Association
2008
Boston Children's Hospital
1999-2008
Texas Children's Hospital
2005
Baylor College of Medicine
2005
Harvard University
1999
Importance Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults is associated with poor short-term long-term outcomes. Guidance required to focus efforts related expansion of pediatric AKI knowledge. Objective To develop expert-driven specific recommendations on needed research, education, practice, advocacy. Evidence Review At the 26th Acute Disease Quality Initiative meeting conducted November 2021 by 47 multiprofessional international...
This article reports demographic characteristics and intensive care unit survival for 344 patients from the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry, a voluntary multicenter observational network.Ages were newborn to 25 yr, 58% male, weights 1.3 160 kg. Patients spent median of 2 d in before CRRT (range 0 135). At initiation, 48% received diuretics 66% vasoactive drugs. Mean blood flow was 97.9 ml/min 10 350 ml/min; 100 ml/min); mean per body weight 5 kg...
Background. Heparin (hepACG) and regional citrate anticoagulation (citACG) remain the most commonly reported continuous renal replacement therapy (CRRT) ACG methods employed. No prospective multi-centre published data exist that compare different with respect to CRRT filter life span or patient complications.
Purpose Well-functioning vascular access is essential for the provision of adequate CRRT However, few data exist to describe effect catheter size or location on performance in pediatric population. Methods Data site, size, and location, as well type anticoagulant used patient demographic were gathered from ppCRRT registry. Kaplan-Meier curves generated then analyzed by log-rank test Cox Proportional Hazards model. Results Access diameter was found significantly affect circuit survival. None...
ABSTRACT Epithelial cell morphology and cytoskeletal organization are determined by interactions, with both adjacent cells the extracellular matrix, which mediated integrins cadherins. Little is known, however, of relative contributions cadherins to maintaining sub-cortical cytoskeleton characteristic epithelial cells. Since most studies that utilize integrin-blocking antibodies result in a loss cell-cell adhesion organization, it has been difficult distinguish whether mediate assembly...
Few published reports describe nutrition provision for critically ill children and young adults with acute kidney injury receiving continuous renal replacement therapy. The goals of this study were to feeding practices in pediatric therapy evaluate factors associated over- under-prescription protein calories.Retrospective database study.Multicenter critical care units.Patients (estimated glomerular filtration rate < 75 mL/min/1.73 m at initiation) enrolled the Prospective Pediatric...
To determine whether integrated continuous renal replacement therapy provides more accurate fluid management than IV pump free-flow ultrafiltration in pediatric patients on extracorporeal life support.Retrospective study.PICU and neonatal ICU a tertiary academic center.Infants children less 18 years old.Extracorporeal membrane oxygenation therapy.Clinical data collected who received or while support. Normalized error was calculated as: (physician specified loss per 24-hr period - actual...
Continuous renal replacement therapy is the most often implemented dialysis modality in pediatric intensive care unit setting for patients with acute kidney injury. However, it also has a role management of nonrenal indications such as clearance drugs and intermediates disordered cellular metabolism.Using data from multicenter Prospective Pediatric Renal Replacement Therapy Registry, we report cohort receiving continuous indications. Nonrenal were obtained combination "other" category...
Acute kidney injury (AKI) in children is associated with increased morbidity, reduced health-related quality of life, greater resource utilization, and higher mortality. Improvements the timeliness precision AKI diagnosis are needed. In this report, we highlight existing, novel, on-the-horizon diagnostic risk-stratification tools for pediatric AKI, outline opportunities integration into clinical practice. We also summarize pediatric-specific high-risk diagnoses exposures as well potential...
Benfield MR, Symons JM, Bynon S, Echkoff D, Herrin J, Harmon WE, Kohaut EC. Mycophenolate mofetil in pediatric transplantation. Pediatr Transplantation 1999: 3: 33–37. © Munksgaard, 1999 Abstract: The use of mycophenolate (MMF) adult renal transplantation has been associated with significantly decreased incidence acute rejection. However, limited data are available for children after A total 67 patients undergoing at the University Alabama Birmingham, AL, USA and Children’s Hospital Boston,...