A5078259028- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Poisoning and overdose treatments
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Neonatal Respiratory Health Research
- Pediatric Urology and Nephrology Studies
- Atmospheric chemistry and aerosols
- Cardiac Arrest and Resuscitation
- Renal and related cancers
- Central Venous Catheters and Hemodialysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Hemodynamic Monitoring and Therapy
- Neonatal Health and Biochemistry
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Spinal Fractures and Fixation Techniques
- Urological Disorders and Treatments
University of Rochester
2018-2024
University of Rochester Medical Center
2019-2024
Colorado Kidney Care
2024
Golisano Children's Hospital
2018-2024
University of Iowa Stead Family Children’s Hospital
2011-2023
University Medical Center
2023
C. S. Mott Children's Hospital
2000-2022
University of Michigan
2000-2022
University of Iowa
2011-2021
Colorado State University
2015-2021
Urinary tract malformations constitute the most frequent cause of chronic renal failure in first two decades life. Branchio-otic (BO) syndrome is an autosomal dominant developmental disorder characterized by hearing loss. In branchio-oto-renal (BOR) syndrome, kidney or urinary are associated. Haploinsufficiency for human gene EYA1 , a homologue Drosophila eyes absent ( eya ), causes BOR and BO syndromes. We recently mapped locus BOR/BO BOS3 ) to chromosome 14q23.1. Within 33-megabase...
Abstract. Formic acid (HCOOH) is one of the most abundant acids in atmosphere, with an important influence on precipitation chemistry and acidity. Here we employ a chemical transport model (GEOS-Chem CTM) to interpret recent airborne ground-based measurements over US Southeast terms constraints they provide HCOOH sources sinks. Summertime boundary layer concentrations average several parts-per-billion, 2–3× larger than can be explained based known production loss pathways. This indicates or...
Importance Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults is associated with poor short-term long-term outcomes. Guidance required to focus efforts related expansion of pediatric AKI knowledge. Objective To develop expert-driven specific recommendations on needed research, education, practice, advocacy. Evidence Review At the 26th Acute Disease Quality Initiative meeting conducted November 2021 by 47 multiprofessional international...
The outgrowth of the ureteric bud from posterior nephric duct epithelium and subsequent invasion into metanephric mesenchyme initiate process metanephric, or adult kidney, development. receptor tyrosine kinase RET glial cell-derived neurotrophic factor (GDNF) form a signaling complex that is essential for growth branching morphogenesis epithelium. We demonstrate Pax2 expression in independent induction by bud. mutants are deficient do not express GDNF uninduced mesenchyme. Furthermore,...
This article reports demographic characteristics and intensive care unit survival for 344 patients from the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry, a voluntary multicenter observational network.Ages were newborn to 25 yr, 58% male, weights 1.3 160 kg. Patients spent median of 2 d in before CRRT (range 0 135). At initiation, 48% received diuretics 66% vasoactive drugs. Mean blood flow was 97.9 ml/min 10 350 ml/min; 100 ml/min); mean per body weight 5 kg...
Background. Heparin (hepACG) and regional citrate anticoagulation (citACG) remain the most commonly reported continuous renal replacement therapy (CRRT) ACG methods employed. No prospective multi-centre published data exist that compare different with respect to CRRT filter life span or patient complications.
Rib fractures are uncommon in infancy and, when diagnosed, often raise the suspicion of child abuse. However, prevalence other causes rib has not been well defined. The purpose this study was to determine and clinical presentations infants <12 months old.Retrospectively, we identified all with under 12 old over a 3-year period using computerized databases at Children's Hospital Medical Center Cincinnati, Ohio Hospital, Winnipeg, Manitoba, Canada. Data extracted from individual patient charts...
Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases in childhood. However, the etiology and pathogenesis SSNS remain obscure. Hypothesizing that coding variation may underlie risk, we conducted an exome array association study SSNS. We enrolled a discovery set 363 persons (214 South Asian children with 149 controls) genotyped them using Illumina HumanExome Beadchip. Four common single nucleotide polymorphisms (SNPs) HLA-DQA1 HLA-DQB1 (rs1129740, rs9273349, rs1071630,...
Summary The case of a 12-year-old with hybrid CFH/CFHL1 gene and atypical hemolytic uremic syndrome (aHUS) that had previously developed native kidney then renal allograft loss is reported. This illustrates the relatively common occurrence from late presentation aHUS. Also presented protocol for pre-emptive use eculizumab plasmapheresis as part transplant plan treatment aHUS in patients deemed at high risk recurrent disease. was result multidisciplinary approach including adult pediatric...
Neonatal AKI is associated with poor short- and long-term outcomes. The objective of this study was to describe the risk factors outcomes neonatal in first postnatal week.The international retrospective observational cohort study, Assessment Worldwide Epidemiology Neonates (AWAKEN), included neonates admitted a intensive care unit who received at least 48 hours intravenous fluids. Early defined by an increase serum creatinine >0.3 mg/dl or urine output <1 ml/kg per hour on days 2-7,...