A5052681595- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Systemic Lupus Erythematosus Research
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- T-cell and B-cell Immunology
- Aluminum toxicity and tolerance in plants and animals
- Retinoids in leukemia and cellular processes
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Mass Spectrometry Techniques and Applications
- Health, Environment, Cognitive Aging
- Molecular Biology Techniques and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Estrogen and related hormone effects
- Health disparities and outcomes
- Bone and Dental Protein Studies
- Nuclear Receptors and Signaling
- Plant-based Medicinal Research
Texas Tech University Health Sciences Center
2021-2025
Texas Tech University
2021-2025
Innsbruck Medical University
2010-2014
The purpose of our study is to determine the protective effects mitophagy enhancers against mutant APP and amyloid beta (Aβ)-induced mitochondrial synaptic toxicities in Alzheimer's disease (ad). Over two decades research from lab others revealed that abnormalities are largely involved pathogenesis both early-onset late-onset ad. Emerging studies impaired clearance dead or dying mitochondria an early event process. Based on these changes, it has been proposed potential therapeutic candidates...
In the current study, we investigated protective role of citalopram against cognitive decline, impaired mitochondrial dynamics, defective biogenesis, autophagy, mitophagy and synaptic dysfunction in APP transgenic mouse model Alzheimer's disease (ad). We treated 12-month-old wild-type (WT) age-matched mice with for 2 months. Using Morris Water Maze rotarod tests, quantitative RT-PCR, immunoblotting, biochemical methods transmission electron microscopy methods, assessed behavior, RNA protein...
In the current study, for first time, we study mitophagy enhancer urolithin A and a combination of A+green tea extract EGCG against human Aβ peptide-induced mitochondrial synaptic, dendritic, inflammatory toxicities behavioral changes in humanized homozygous amyloid beta knockin (hAbKI) mice late-onset Alzheimer's disease (AD). Our findings reveal significantly increased positive effects treatment A+EGCG hAbKI phenotypic including motor coordination, locomotion/exploratory activity, spatial...
Abstract Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the form of sugars, amino acids, and lipids. Particularly, acids are critical cancer growth and, as intermediates, connect glucose, lipid nucleotide metabolism. PDAC meet these requirements by upregulating selective acid transporters. Here we show that SLC38A5 (SN2/SNAT5), neutral transporter is highly upregulated functional cells. Using CRISPR/Cas9-mediated knockout SLC38A5, its tumor promoting role...
Abstract Th17 cells infiltrate the kidneys of patients with lupus nephritis (LN) and are critical for pathogenesis this disease. In study, we show that enhanced activity Stat3 in CD4+CD45RA−Foxp3− Foxp3low effector T from children LN correlates increased frequencies IL-17–producing within these cell populations. The levels retinoic acid-related orphan receptor c IL-17 mRNA significantly higher PBMCs than those controls. Mammalian target rapamycin inhibition by reduces both activation...
The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied phenotype parameters, including spatial learning memory (Morris Water Maze), locomotor activity (open field), working (Y-maze) motor coordination (rotarod); mRNA abundance, protein levels, soluble amyloid-beta 40 42 levels regional immunoreactivities key markers mitochondrial...
The purpose of our study is to understand the role
RalBP1 (Rlip) is a stress-activated protein that believed to play large role in aging and neurodegenerative diseases such as Alzheimer’s disease (AD) other tauopathies. The purpose of our study was understand the Rlip mutant Tau-expressed immortalized hippocampal HT22 cells. In current study, we used Tau (mTau)-expressed neurons cells transfected with Rlip-cDNA and/or silenced RNA, studied cell survival, mitochondrial respiration, function, immunoblotting, immunofluorescence analysis...
During the 1990s, populations of two species griffon vulture, Indian white-backed Gyps bengalensis and long-billed indicus, declined by more than 90% throughout India. These declines are continuing due to abnormally high rates both nesting failure adult, juvenile nestling mortality. Affected birds exhibit signs illness (neck drooping syndrome) for approximately 30 days prior death. Epidemiological observations most consistent with an infectious cause this morbidity To investigate these...