A5074206527- Pharmaceutical studies and practices
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Renal Transplantation Outcomes and Treatments
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Child and Adolescent Health
- Acute Kidney Injury Research
- Epilepsy research and treatment
- Childhood Cancer Survivors' Quality of Life
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Statistical Methods in Clinical Trials
Erasmus MC - Sophia Children’s Hospital
2016-2025
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2019-2024
Queen's University
2020-2024
Brigham and Women's Hospital
2023-2024
Harvard University
2023-2024
University of Groningen
2024
Erasmus MC
2003-2023
Erasmus University Rotterdam
1999-2023
Importance Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such respiratory depression.Objective To determine whether intravenous paracetamol (acetaminophen) would significantly (Ͼ30%) reduce requirements neonates and after major surgery.Design, Setting, Patients Single-center, randomized, double-blind study conducted a level 3 pediatric intensive care unit Rotterdam, the Netherlands.Patients were 71 or...
Many drugs prescribed to children are drug transporter substrates. Drug transporters membrane-bound proteins that mediate the cellular uptake or efflux of and important absorption elimination. Very limited data available on effect age expression. Our study assessed age-related gene expression hepatic intestinal transporters. Multidrug resistance protein 2 (MRP2), organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3 was determined in postmortem liver samples (fetal n = 6, neonatal...
Newborns in need of extracorporeal membrane oxygenation (ECMO) support are at high risk developing acute kidney injury (AKI). AKI may occur as part multiple organ failure and can be aggravated by exposure to components the circuit. necessitates adjustment dosage renally eliminated drugs avoidance nephrotoxic drugs. We aimed define systematically incidence clinical course critically ill neonates receiving ECMO support.This study reviewed prospectively collected data (including age, diagnosis,...
Drug transporters are critically important for the absorption, distribution, metabolism, and excretion (ADME) of many drugs endogenous compounds. Therefore, disruption these pathways by inhibition, induction, genetic polymorphisms, or disease can have profound effects on overall physiology, drug pharmacokinetics, efficacy, toxicity. This white paper provides a review changes in transporter function associated with acute chronic states, describes regulatory affecting expression, identifies...
Various in vitro, animal, and limited human adult studies suggest a profound inhibitory effect of inflammation disease on cytochrome P-450 3A (CYP3A)-mediated drug metabolism. Studies showing this relationship critically ill patients are lacking, whereas clearance many CYP3A substrates may be decreased, potentially leading to toxicity.To prospectively study the between inflammation, organ failure, midazolam as validated marker CYP3A-mediated metabolism children.From 83 children (median age,...
Human renal membrane transporters play key roles in the disposition of renally cleared drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human postmortem frozen cortical tissues (preterm newborns to adults) a subset 62 tissue samples, we measured mRNA levels 11 transcription factor pregnane X receptor (PXR) with quantitative real‐time polymerase chain reaction, protein abundance nine using liquid chromatography tandem mass spectrometry selective reaction...
Objective To determine the pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Design Prospective population pharmacokinetic study. Setting Pediatric unit. Patients Twenty-one patients aged between 2 days 17 yrs. Interventions The metabolites were determined during after a continuous infusion (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 administered conscious sedation. Measurements Main Results Blood samples taken at different times determination midazolam,...
Abstract Background The COMFORT behaviour scale ( ‐ B scale) is widely used in paediatric intensive care units to assess young children's pain and distress. It also the impact of treatment interventions, but little known on scale's sensitivity detect changes between before after measurements following an intervention. This study explored change scale. Methods scores, originally prospectively collected as part standard care, were retrieved from digital patient data management system. We...