Endrias Ergetu
A5012852755- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Nosocomial Infections in ICU
- Congenital Heart Disease Studies
- Antibiotic Use and Resistance
- Mechanical Circulatory Support Devices
- Meta-analysis and systematic reviews
- Clinical Reasoning and Diagnostic Skills
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Ethics in Clinical Research
- Pharmaceutical studies and practices
- Statistical Methods in Clinical Trials
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
The University of Queensland
2021-2024
Children's Medical Research Institute
2024
Mater Research
2023
In children undergoing heart surgery, nitric oxide administered into the gas flow of cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration respiratory support. It remains uncertain whether improves ventilator-free days (days alive free from mechanical ventilation).
Sepsis bundles, promulgated by Surviving Campaign have not been widely adopted because of variability in sepsis identification strategies, implementation challenges, concerns about excess antimicrobial use, and limited evidence benefit.A 1-hour septic shock a 3-hour bundle were implemented using Breakthrough Series Collaborative 14 public hospitals Queensland, Australia. A before (baseline) after (post-intervention) study evaluated its impact on outcomes prescription patients with confirmed...
Importance Children with congenital heart defects who undergo cardiopulmonary bypass (CPB) surgery are at risk for delayed or impaired neurodevelopmental outcomes. Nitric oxide (NO) added to the CPB oxygenator may reduce systemic inflammation due and improve recovery from surgery, including improved Objective To investigate neurodevelopment, health-related quality of life (HRQOL), factors associated neurodevelopment 12 months post in infants received NO standard CPB. Design, Setting,...
Background/Aims Regulatory guidelines recommend that sponsors develop a risk-based approach to monitoring clinical trials. However, there is lack of evidence guide the effective implementation activities encompassed in this approach. The aim study was assess efficiency and impact used for multicentre randomised controlled trial comparing treatments paediatric patients undergoing cardiac bypass surgery. Methods This secondary analysis data from implemented targeted source verification as part...
We examined systems-level costs before and after the implementation of an emergency department paediatric sepsis screening, recognition treatment pathway. Aggregated hospital admissions for all children aged < 18y with a diagnosis code upon admission in Queensland, Australia were compared 16 participating 32 non-participating hospitals pathway implementation. Monte Carlo simulation was used to generate uncertainty intervals. Policy impacts estimated using difference-in-difference analysis...
To determine if the introduction of an emergency department (ED) sepsis screening tool and management bundle affects antibiotic prescribing use.Multicentre, cohort, before-and-after study design.Three tertiary hospitals in Queensland, Australia (median bed size 543, range 520-742).Adult patients, presenting to ED with symptoms signs suggestive who had blood cultures collected. These participants were further assessed stratified as having septic shock, or infection alone, using Sepsis-3...
To identify the health and economic costs of hospital-acquired complications (HACs) in children who require PICU admission. Propensity score matched cohort study analyzing routinely collected medical costing data by service over 6 years (2015-2020). Tertiary referral Queensland, Australia. All admitted to were included. None. We assessed ventilator- respiratory support-free days at 30 post-PICU admission, length stay, prevalence individual HACs, attributable healthcare costs. A total 8437...
Background: Implementing 1-hour and 3-hour sepsis bundles for patients presenting with bacteraemia to public hospital emergency departments in the State of Queensland resulted improved bundle compliance a reduced need ICU admission post-implementation phase as compared baseline. Detailed investigation impact implementation on antibiotic prescribing has not previously been reported.Methods: A nested cohort study three hospitals evaluating prescription. The primary outcome was adherence...