A5026177703- Lysosomal Storage Disorders Research
- Cytomegalovirus and herpesvirus research
- Calcium signaling and nucleotide metabolism
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Complement system in diseases
- Advancements in Transdermal Drug Delivery
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- Glycogen Storage Diseases and Myoclonus
University of Edinburgh
2024-2025
Centre for Inflammation Research
2024
University of Oxford
2015-2020
Mansfield University
2020
University of Michigan
2016-2017
Acetyl-dl-leucine is a derivative of the branched chain amino acid leucine. In observational clinical studies, acetyl-dl-leucine improved symptoms ataxia, in particular patients with lysosomal storage disorder, Niemann-Pick disease type C1. Here, we investigated and its enantiomers acetyl-l-leucine acetyl-d-leucine symptomatic Npc1-/- mice observed improvement ataxia both individual acetyl-dl-leucine. When were administered pre-symptomatically to mice, treatments delayed progression extended...
Niemann-Pick disease type C (NPC) is a lysosomal storage with heterogeneous neurodegenerative clinical course. Multiple therapies are in trials and inclusion criteria currently mainly based on age neurological signs, not taking into consideration differential individual rates of progression. In this study, we have evaluated simple metric, denoted annual severity increment score (ASIS), that measures rate progression could easily be used practice. We show ASIS stable over several years can to...
<ns4:p><ns4:italic>Background. </ns4:italic>Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is key mechanism by which intracellular mycobacteria, including<ns4:italic>Mycobacterium tuberculosis</ns4:italic>, achieve long-term persistence within host cells. mechanisms underpinning this pro-survival strategy remain incompletely understood. Host macrophages infected with persistent mycobacteria share phenotypic similarities cells taken from...
<ns4:p><ns4:italic><ns4:bold>Background</ns4:bold>. </ns4:italic>Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is key mechanism by which intracellular mycobacteria, including<ns4:italic>Mycobacterium tuberculosis</ns4:italic>, achieve long-term persistence within host cells. mechanisms underpinning this pro-survival strategy remain incompletely understood. Host macrophages infected with mycobacteria share phenotypic similarities cells...
Drug-induced liver injury (DILI) is a challenge in clinical medicine and drug development. Highly sensitive novel biomarkers have been identified for detecting DILI following paracetamol overdose. The study objective was to evaluate biomarker performance 14-day trial of therapeutic dose paracetamol. PATH-BP double-blind, placebo-controlled, crossover study. Individuals (n = 110) were randomized receive 1 g 4× daily or matched placebo 2 weeks followed by 2-week washout before crossing over...
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 COVID-19 cases 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 present 2.4% young (<60 years) no reported clinical (n = 378), compared 0.24% (odds ratio [OR] 12.3, p 1.27 × 10
<title>Abstract</title> Paracetamol overdose (POD) is common, with approximately 100,000 cases attending hospital emergency departments in the UK annually. Early treatment antidote <italic>N</italic>-acetylcysteine (NAC) crucial for patients who are at risk of developing life-threatening acute liver failure. A rapid point-of-care (POC) assay required to identify high-risk fit-for-purpose sensitivity and specificity facilitate early targeted NAC treatment. Here we demonstrate that measuring a...
<ns4:p><ns4:italic><ns4:bold>Background</ns4:bold>. </ns4:italic>Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is key mechanism by which intracellular mycobacteria, including<ns4:italic>Mycobacterium tuberculosis</ns4:italic>, achieve long-term persistence within host cells. mechanisms underpinning this pro-survival strategy remain incompletely understood. Host macrophages infected with mycobacteria share phenotypic similarities cells...
Abstract Acetyl-DL-leucine (ADLL) is a derivative of the branched chain amino acid leucine. In observational clinical studies ADLL improved symptoms ataxia, in particular patients with lysosomal storage disorder (LSD), Niemann-Pick disease type C 1 (NPC1). Here, we investigated and its enantiomers acetyl-L-leucine (ALL) acetyl-D-leucine (ADL) symptomatic Npc1 -/- mice observed an improvement ataxia both ADLL. When ALL were administered pre-symptomatically to mice, treatments delayed...