A5004215185- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Bone health and treatments
- Signaling Pathways in Disease
- Hypothalamic control of reproductive hormones
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bone Metabolism and Diseases
- Magnesium in Health and Disease
- Vitamin K Research Studies
- Nitric Oxide and Endothelin Effects
- Vitamin D Research Studies
- S100 Proteins and Annexins
- Parathyroid Disorders and Treatments
- Regulation of Appetite and Obesity
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Health and Disease Prevention
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Eicosanoids and Hypertension Pharmacology
- Adrenal Hormones and Disorders
- Bone health and osteoporosis research
Edinburgh Royal Infirmary
2009-2024
The Queen's Medical Research Institute
2008-2024
University of Edinburgh
2009-2024
NHS Lothian
2021-2024
National Health Service
2021-2024
Western General Hospital
2024
Queen's University
2023
William Harvey Research Institute
1992-2018
Queen Mary University of London
2003-2018
University of London
1985-2018
In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess mechanisms underlying this superiority and pathogenesis hypertension.PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary secondary care sites in 314 patients with hypertension. Patients were given 12 weeks once daily treatment each placebo, 25-50 mg, bisoprolol 5-10 doxazosin 4-8 mg...
Research Article| November 01 1958 The production of secondary potassium depletion, sodium retention, nephrocalcinosis and hypercalcaemia by magnesium deficiency I. MacIntyre; MacIntyre 1Postgraduate Medical School, Ducane Road, London, W. 12 Search for other works this author on: This Site PubMed Google Scholar D. Davidsson * Biochem J (1958) 70 (3): 456–462. https://doi.org/10.1042/bj0700456 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share...
The osteoclast is unique in its ability to resorb bone, and excessive osteoclastic activity has been implicated osteoporosis, Paget disease of rheumatoid arthritis, the growth metastases bone. this cell controlled by main circulating inhibitor, calcitonin, association with locally produced modulators. We show that nitric oxide (NO) may be an important member latter group. NO vascular endothelium nervous system involved both neurotransmission regulation blood pressure. However, our results...
Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, this effect is accompanied by a profound inhibition of bone resorption. Work others has confirmed these findings vivo: NO synthase [NOS; L-arginine, NADPH: oxygen oxidoreductase (NO-forming), EC 1.14.13.39] normal rats followed increased resorption reflected marked loss mineral density. In our present study, immunocytochemistry Northern blotting show the presence constitutive calcium-sensitive NOS isoform (cNOS)...
Bombesin, a peptide with widespread biological actions, has been demonstrated in human tissues by immunological methods. To investigate its effect man, synthetic bombesin was infused at low doses six male volunteers. Bombesin 2.4 pmol kg−1 min−11 produced significant rises plasma insulin, glucagon, pancreatic polypeptide, gastrin, cholecystokinin, motilin, glucose-dependent insulinotropic neurotensin, enteroglucagon, vasoactive intestinal and serum calcium. In contrast, caused profound fall...
In addition to calcitonin and katacalcin, it is now known that the human gene encodes a novel peptide called related (CGRP). experimental animals, CGRP produces vasodilatation complex changes in plasma calcium. We have assessed its biological activity man by infusing (hCGRP) into six normal volunteers. hCGRP (545 pmol/min) caused diastolic pressure fall from 64 +/- 5 55 7 mmHg (P less than 0.05), heart rate increase 61 87 beats/min 0.05) skin temperature 33.7 0.9 34.9 0.5 degrees C. Plasma...