Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), utilization (CMRO2) and volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method positron emission tomography. Between subjects CBF correlated positively with CMRO2, although interindividual variability values was large. OER not dependent on but highly negatively CBF. CBV When considering all regions interest within single subject, strict coupling...

SUMMARY When a study produces estimates for many units or categories common problem is that end-users will wish to make their own comparisons among subset of these units. This occur, example, when school performance are produced all schools. The paper proposes procedure, based on the graphical presentation confidence intervals, which enables such be carried out while maintaining an average required type I error rate. means two independent samples presented graphically, it practice accompany...

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The analysis of repeated measures data can be conducted efficiently using a two-level random coefficients model. A standard assumption is that the within-individual (level 1) residuals are uncorrelated. In some cases, especially where measurements made close together in time, this may not reasonable and additional correlation structure should also modelled. time series model for such proposed which consists multilevel augmented by an autocorrelation level 1 residuals. First- second-order...

We have assessed the medium-term effect of a short course high-dose, alternate-day prednisolone on adult nephrotic patients with membranous nephropathy, using randomized, prospective, double-blind, controlled trial. Patients were entered over period 1981 to 1984 and observed for minimum three years. One hundred seven who had not previously received immunosuppressive treatment included in sixty further patients, excluded from trial, but nephropathy identified, followed assesed retrospectively...

The statistical processing of radioimmunoassay data is discussed, with special emphasis on fitting the standard curve, screening for aberrant readings and combining separate estimations from a single sample.

Swedish population reference standards for height, weight and body mass index (BMI) attained at 6 to 16 years (girls) or 19 (boys) are presented. Data were obtained from two independent nationwide samples of children; one (740 children) born in 1955, the other (2907 1967. The weights children 1955 adjusted equal those 1967; heights did not differ. These refer therefore around 1970. observations fitted by power transformation, L, M, S method Cole Green. Weights BMIs thus normalized valid SD...

Assessment of Skeletal Maturity and Prediction Adult Height (TW2 Method). By J. M. Tanner, R. H. Whitehouse, W. A. Marshall, Healy Goldstein. London New York, Academic Press, 1975. vii, 99p. 31 cm. £9·00.

The problems of constructing population standards for measurements such as height and age points menarche are discussed. Extreme centiles, the 3rd, estimated from a Gaussian distribution have considerable imprecision, amount which is detailed. Non-parametric estimation, usually used weight, compared with transformation to Gaussianity thence parametric estimation. Regression discussed, whereby subject relevant subsection rather than all it, it suggested that velocity growth might be couched...

In polytocous mammals an inverse relation is known to exist between the number of young in litter and size at birth. It has been customary attribute this prenatal competition for a limited pool nutrients maternal circulation (Hammond & Marshall 1952). The present study was undertaken order subject traditional theory quantitative test. Pregnant mice were killed shortly before term their foetuses weighed. Some pregnancies had resulted from natural ovulation. Others obtained by inducing...

The extent to which the measurement of airways resistance by interrupter technique (Rint) distinguishes preschool children with previous wheeze from those no respiratory symptoms and helps classify subjects persistent cough, was investigated. Rint measured before after salbutamol treatment in 82 recurrent wheeze, 58 isolated cough 48 (control subjects). Their mean age (range) 3.7 yrs (2-<5 yrs). Median baseline higher (p<0.0001) wheezers than either coughers or control (1.16, 0.94 0.88...

Summary BACKGROUND AND OBJECTIVE Ovarian Uh8SOnOgra‐phy may be helpful in distinguishing the various types of precocious puberty, and ovarian appearances Increasingly influence choice therapy In these girls. We examined retrospectively volume prevalence polycystic appearance at ultrasound girls with sexual precocity. DESIGN Ultrasound examinations were obtained from who presented If there several scans same Individual, latest was analysed. PATIENTS The divided Into groups: untreated central...

where the sum of squares are derived from standard analysis variance. It is well known that R2 misleading when used to compare fit regressions involving different numbers predictors. The regression cannot decrease new predictors added equation, so increasing number will usually increase even true values coefficients zero. In a recent article, Draper (1984) shows normally reduced replicate y introduced at existing x. situation clear in terms Suppose we relationship = X,B with k plus constant...

Abstract Three new cases of spinal cord compression due to vertebral hemangioma are reported. The clinical presentation, with pain, radicular radiation, and paraparesis, is similar that primary lymphoma, metastatic tumor, disc disease. If the characteristic plain film changes vertical trabeculations striations present, preoperative diagnosis facilitated, but in majority these not seen. In some instances, body or pedicle erosion present. A myelographic epidural block will be seen on further...

BACKGROUND: The pattern of growth the uterus was examined by ultrasound examinations 358 girls who attended a paediatric endocrine outpatient department but were shown not to have any defect. METHOD: measured in length and width at cervix fundus (cm). Endometrial thickness (mm). Scans divided Tanner breast stage dimensions compared one way analysis variance (ANOVA, with Student Newman Keuls post hoc test). RESULTS: There an increase uterine length, diameter fundus, endometrial each from 1 5...

Emphasis has been placed on the importance of 13, type II error, in clinical trials and corresponding necessity including large numbers subjects a study.' Large are fashion small trials-even when they yield statistically significant results-are regarded with suspicion; trial which does not show conventional difference is often thought worthless.Interpretation increasingly recognised to be dangerous, argument that lack between two treatments must mean have equal efficacy false.The need for...

A case is presented of pulmonary Langerhans' cell granulomatosis which recurred following lung transplantation and responded to cyclophosphamide. This suggests that the primary abnormality in this condition lies or precursor dendritic cell.