A5011673660- Immune responses and vaccinations
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Emergency and Acute Care Studies
- Bacterial Infections and Vaccines
- Cardiac, Anesthesia and Surgical Outcomes
- Child Nutrition and Water Access
- Immunodeficiency and Autoimmune Disorders
- Airway Management and Intubation Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Family and Patient Care in Intensive Care Units
- Cardiac Arrest and Resuscitation
- Child and Adolescent Health
- Hemodynamic Monitoring and Therapy
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Thermal Regulation in Medicine
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Tuberculosis Research and Epidemiology
The University of Melbourne
2015-2024
Florey Institute of Neuroscience and Mental Health
2024
Royal Children's Hospital
2013-2022
Office of Infectious Diseases
2021
Murdoch Children's Research Institute
2011-2016
Queensland Children’s Hospital
2016
Children's Hospital at Westmead
2016
Sydney Children's Hospital
2016
Women's and Children's Hospital
2016
Intensive Care Society
2009-2013
To provide an updated version of the Paediatric Index Mortality 2 for assessing risk mortality among children admitted to ICU.International, multicenter, prospective cohort study.Sixty ICUs that accept pediatric admissions in Australia, New Zealand, Ireland, and United Kingdom.All 2010 2011 younger than 18 years old at time admission either died ICU or were discharged. Patients who transferred another not included. Fifty-three thousand one hundred twelve patient included analysis.None.A...
To describe the characteristics of children admitted to intensive care in 1982, 1995, and 2005-2006, their long-term outcome.Pediatric unit a university-affiliated children's hospital.Information for 2005-2006 admissions was obtained from pediatric database, outcome ascertained through telephone interviews. Results were compared previous cohorts 1982 1995.A total 4010 on 5250 occasions. Readmissions increased 11% 31% 2005 2006 (p < .001). In fewer after accidents .001), or with croup...
Objective: To assess the effect of plasmafiltration (PF) on biochemical markers inflammation, cytokines, organ dysfunction, and 14-day mortality in human sepsis. Design: Multicenter, prospective, randomized, controlled clinical trial. Setting: Seven university-affiliated intensive care units. Patients: Thirty patients (22 adults, eight children) with new (<24 hrs) evidence infection sepsis syndrome were enrolled. Fourteen 30 (nine five randomized to PF. Interventions: All received...
Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.
Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across globe generating formulations that may differ in clinical efficacy. Innate immune recognition of BCG contributes to immunogenicity suggesting differences viability contribute divergent activity licensed formulations.We compared BCG-Denmark (DEN), -Japan (JPN), -India (IND), -Bulgaria (BUL) and -USA vitro with respect a) as measured by colony-forming units (CFU),...
Objective: To compare the performance of Pediatric Index Mortality (PIM), PIM2, Risk (PRISM), and PRISM III in Australia New Zealand. Design: A two-phase prospective observational study. Phase 1 assessed PIM, PRISM, between 1997 1999. 2 PIM2 2000 2001. Setting: Ten intensive care units Patients: Included study were 26,966 patients aged <16 yrs; 1,147 died unit. Interventions: None. Measurements Main Results: Discrimination death survival was by calculating area under receiver operating...
Infection with antibiotic-resistant (AR) Gram-negative (GN) bacteria is associated increased morbidity and mortality. The aim of this study was to determine risk factors outcomes GN bacteremia acquired resistance antibiotics used in the empiric treatment febrile neutropenia pediatric oncology patients at our institution.All episodes Royal Children's Hospital Melbourne, from 2003 2010 were retrospectively reviewed. Information regarding age, diagnosis, phase treatment, inpatient status,...
The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against vaccine-specific disease, may also have "non-specific effects" affecting risk of unrelated diseases. Accumulating evidence from epidemiological studies shows some situations can affect all-cause mortality morbidity ways are not explained by prevention vaccine-targeted disease. Live attenuated sometimes been associated with decreases greater than...