A5021684754- Genetic Associations and Epidemiology
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Genetic Mapping and Diversity in Plants and Animals
- Smoking Behavior and Cessation
- Adolescent Sexual and Reproductive Health
- Sex work and related issues
- Sexual Assault and Victimization Studies
- Cannabis and Cannabinoid Research
- Mindfulness and Compassion Interventions
- Genetic and phenotypic traits in livestock
- Child Abuse and Trauma
- Genomics and Rare Diseases
- Neurotransmitter Receptor Influence on Behavior
- Genetic Syndromes and Imprinting
- Urban Green Space and Health
- Cryospheric studies and observations
- Epigenetics and DNA Methylation
- Climate change and permafrost
- Land Use and Ecosystem Services
- Behavioral Health and Interventions
- Nutrition, Genetics, and Disease
- Gender, Feminism, and Media
- Renal Diseases and Glomerulopathies
- Problem Solving Skills Development
Regeneron (United States)
2022-2025
Humboldt-Universität zu Berlin
2024
University of Minnesota
2020-2022
Stockholm University
2022
University of Missouri
2016-2021
Washington University in St. Louis
2016
University of Washington
2009-2013
Washington State University Vancouver
2010
Indiana University – Purdue University Indianapolis
2010
Indiana University School of Medicine
2010
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Abstract Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential identify drug targets. We performed an exome-wide association study phenotypes in up 749,459 individuals and discovered a protective CHRNB2 , encoding β2 subunit α4β2 nicotine acetylcholine receptor. Rare predicted loss-of-function likely deleterious missense aggregate were associated with 35% decreased odds for heavily (odds ratio (OR) =...
This study examined relationships among language use, mindfulness, and substance-use treatment outcomes in the context of an efficacy trial mindfulness-based relapse prevention (MBRP) for adults with alcohol other drug use (AOD) disorders. An expert panel generated two categories mindfulness (ML) describing state more encompassing "mindfulness journey," which included words challenges developing a practice. MBRP participants (n = 48) completed baseline sociodemographic AOD measures,...
There is increasing interest in health interventions that incorporate genetic risk information. Although feedback has been evaluated as an adjunct to smoking cessation interventions, its efficacy for reducing alcohol-related risks unknown. The purpose of this study was evaluate the feasibility, acceptability, and a web-based alcohol intervention incorporating information specific ALDH2 genotype. ALDH2*2 variant associated with partial protection against dependence but confers significantly...
Sexually victimized women may make sexual decisions differently than nonvictimized women. This study used an eroticized scenario and laboratory alcohol administration to investigate the roles of victimization history, intoxication, relationship context in women's perceptions a male partner their subsequent intentions for unprotected sex. A community sample 436 completed childhood abuse (CSA) adolescent/adult assault (ASA) measures. After random assignment or control condition, participants...
Understanding residents' perceptions of green-blue infrastructure (GBI) is critical to ensure continued access its associated benefits in growing and densifying urban landscapes. Physical availability accessibility green spaces alone do not directly translate actual appreciation use. Residents' sense place can determine if from GBI are realized how landscape changes may be perceived. In this study, set sub-urban Stockholm, Sweden, we applied a mixed-methods approach combining mental mapping...
In this study, an open-ended decisional balance worksheet was used to elicit self-generated pros and cons of current drinking reducing drinking, which were then quantified create a proportion (DBP) reflecting movement towards change (i.e., counts all fields).This study's goal examine the convergent, discriminant predictive validity DBP as measure motivation change.Participants college students (N=143) who reported having engaged in weekly heavy, episodic had participated larger randomized...
Along the Greenland Ice Sheet margin, supraglacial lakes store and redistribute ice sheet surface run off, comprise an important potential hydrological link between base, with ramifications for subglacial drainage systems flow. As a consequence of increasing global mean air temperatures, these have been predicted to expand further inland affect larger areas sheet. However, as contemporary dynamics such lake expansion are not well studied, any assessment their future implications remains...
Abstract Background and Aims Although genome‐wide association studies have identified many loci that influence smoking behaviors, much of the genetic variance remains unexplained. We characterized architecture four behaviors using single nucleotide polymorphism (SNP) heritability ( h 2 SNP ). This is an estimate narrow‐sense specifically estimating proportion phenotypic variation due to causal variants (CVs) tagged by SNPs. Design Partitioned analysis behavior traits. Setting UK Biobank....
Background A functional polymorphism within the μ ‐opioid receptor ( OPRM 1 ) gene, rs1799971 (A118G), previously has been associated with measures of alcohol use and sensitivity to its effects, but findings have inconclusive. recent study suggested that a second nearby variant 1, rs3778150, is robustly heroin dependence fully explained smaller observed association rs1799971. Given evidence rs3778150‐C allele decreased expression levels in human brain, current sought test hypothesis...
Despite evidence for genetic influences on alcohol use and alcohol-related cognitions, factors endophenotypes are rarely incorporated in cognitive models of drinking behavior. This study evaluated a model ALDH2 behavior stipulating sensitivity as accounting outcomes.Participants were Asian-American young adults (n = 171) who completed measures cognitions (drinking motives, refusal self-efficacy, expectancies), sensitivity, behavior, problems part prospective study. Structural equation...
Shared genetic factors represent one underlying mechanism thought to contribute high rates of alcohol and tobacco co-use dependence. Common variants identified by molecular studies tend confer only small disease risk, rare protein-coding are posited as well. However, given that genotyping technologies allowing for their inclusion in association have recently become available, the magnitude contribution is poorly understood. The current study examined variation regions (i.e., exome)...
Background Prior studies suggest a possible association of promoter polymorphism in the ALDH1A1 gene ( ALDH1A1*2 ) with alcohol use or dependence. The aim this study was to examine drinking behaviors A sian young adults and ALDH2 genotype as potential moderator these associations. Methods n = 951) were recruited from 2 college sites for genetic associations behavior. Participants completed comprehensive background questionnaires on demographics Fingertip blood samples obtained DNA extraction...
Tobacco use is associated with variation at the 15q25 gene cluster and cytochrome P450 (CYP) genes CYP2A6 CYP2B6. Despite variety of outcomes these genes, few studies have adopted a data-driven approach to defining tobacco phenotypes for genetic association analyses. We used factor analysis generate measure, explored its incremental validity over simple indicator involvement: cigarettes per day (CPD), tested both in study.Data were from University California, San Francisco Family Alcoholism...
Objective: Epidemiological estimates suggest that nearly half of individuals diagnosed with alcohol use disorder will be another mental health disorder, strong associations involving other externalizing disorders. Molecular genetic studies investigating the relation between and behaviors (e.g., antisocial behavior) have focused on a cluster chromosome 4 γ-aminobutyric acid (GABA) receptor genes (GABRG1-A2-A4-B1) but generated varying results. Method: The current study examined common rare...
Abstract Background and Aims Smoking is a leading cause of premature death. Although genome-wide association studies have identified many loci that influence smoking behaviors, much the genetic variance in these traits remains unexplained. We sought to characterize architecture four behaviors through SNP-based heritability ( h 2 SNP ) analyses. Design applied recently-developed partitioned approaches behavior assessed UK Biobank. Setting Participants Biobank participants European ancestry....