A5043089914- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Genetic Associations and Epidemiology
- Eicosanoids and Hypertension Pharmacology
- Child and Adolescent Psychosocial and Emotional Development
- Neurotransmitter Receptor Influence on Behavior
- Prenatal Substance Exposure Effects
- Diet, Metabolism, and Disease
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Homelessness and Social Issues
- HIV/AIDS Research and Interventions
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Adolescent and Pediatric Healthcare
- Stress Responses and Cortisol
- Smoking Behavior and Cessation
- Gambling Behavior and Treatments
- Adipose Tissue and Metabolism
- Alcoholism and Thiamine Deficiency
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- High Altitude and Hypoxia
- Racial and Ethnic Identity Research
University of California, San Diego
2015-2024
VA San Diego Healthcare System
2010-2020
UC San Diego Health System
2016-2019
Veterans Medical Research Foundation of San Diego
2007-2018
University of California, Berkeley
2014
Indiana University – Purdue University Indianapolis
2001-2011
University of Southern California
2011
University of Washington
2009-2010
Washington State University Vancouver
2010
Indiana University School of Medicine
2009-2010
OBJECTIVE: Two alcohol dehydrogenase genes (ADH2 and ADH3 on chromosome 4) one aldehyde gene (ALDH2 12) exhibit functional polymorphisms. The goal of this study was to determine whether any associations exist between the ADH2, ADH3, ALDH2 polymorphisms dependence in a group Native Americans. An additional if these endophenotype, maximum number drinks ever consumed 24-hour period. METHOD: Mission Indian adults (N=340) were recruited for participation from reservations southern California....
Asian‐American men who possess ALDH 2*2 alleles and experience a facial flush after consuming alcohol were carefully matched on drinking history demographic variables with nonflushing Asian males only 2*1 alleles. Each man was tested following placebo challenge dose of 0.75 ml/kg alcohol. Following alcohol, flushers reported experiencing significantly more positive feelings intoxication than nonflushers, despite equivalent blood concentrations. These data suggest that Asians drinking,...
Abstract Alcohol dependence is a leading cause of morbidity and mortality in Native Americans, yet biological factors underlying the disorder this ethnic group remain illusive. This study's aims were to map susceptibility loci for DSM‐III‐R alcohol two narrower alcohol‐related phenotypes Mission Indian families. Each participant gave blood sample completed an interview using Semi‐Structured Assessment Genetics Alcoholism (SSAGA) that was used make diagnoses withdrawal, drinking severity....
Background: About half of certain Asians have a deficiency the low-Km aldehyde dehydrogenase (ALDH2) isoenzyme. This results from inheritance mutant ALDH2*2 allele. Objective: To determine whether Asian Americans with alleles differ without this mutation in terms blood levels alcohol and acetaldehyde after ingestion moderate amount alcohol. Design: Double-blind, crossover study. Setting: Private research institute. Participants: 35 healthy Asian-American men. Three men who became ill one had...
OBJECTIVE: This study was conducted to describe the order of appearance and progression alcohol-related life events in Mission Indian men women with a lifetime diagnosis alcohol dependence. METHOD: A total 407 participants completed structured interview that gathered information on diagnoses, remissions, abstinences, treatments as well events. RESULTS: 70% 50% sampled met diagnostic criteria for The age at onset dependence younger (20 years) course proceeded more rapidly (6 than what has...
Abstract This paper describes two clinical techniques aiming to improve adherence medications for HIV/AIDS in methadone maintenance patients. The first technique, providing on-site dispensing of antiretroviral medications, enhanced medication but did not produce enduring effects beyond the time intervention. To develop a more long-lasting intervention, programme is experimenting with individualized management, which staff member provides assessment and problem solving help adherence....
Background: Native Americans, overall, have the highest prevalence of alcohol dependence any US ethnic group. In several large national surveys, has been significantly associated with higher rates anxiety and affective disorders (comorbidity). However, frequencies these their comorbidity in American populations are relatively unknown. Methods: Demographic information DSM‐III‐R diagnoses were obtained by using Semi‐Structured Assessment for Genetics Alcoholism developed Collaborative Study on...