A5088577197- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Advanced Glycation End Products research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Diet, Metabolism, and Disease
- Adrenal Hormones and Disorders
- Acute Myeloid Leukemia Research
- Drug-Induced Adverse Reactions
- Alcohol Consumption and Health Effects
- Stress Responses and Cortisol
- Thyroid Cancer Diagnosis and Treatment
- Pharmaceutical studies and practices
- Skin Protection and Aging
- Hemoglobinopathies and Related Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Blood disorders and treatments
- Cardiovascular Disease and Adiposity
- Respiratory and Cough-Related Research
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
University of Duisburg-Essen
2016
Karolinska Institutet
2016
Maastricht University Medical Centre
2004-2005
Maastricht University
2004
Dutch Health Care Inspectorate
1996-1998
Albert Schweitzer Ziekenhuis
1998
Erasmus University Rotterdam
1990-1996
Medisch Centrum Leeuwarden
1994
Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several large-scale cohort studies. Aim this study was describe prevalence obesity, syndrome (MetS) metabolically healthy (MHO) in ten participating studies.Ten different cohorts seven countries were combined,...
Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact the general population are rare. Furthermore, discussions optimal definition have not conclusive. We investigated these issues using data, scores from a life questionnaire (RAND-36), hemoglobin concentration 138670 subjects, aged 18-93 years, participating Lifelines cohort. was...
Earlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in skin, which increases ageing and is associated metabolic syndrome type 2 diabetes. In present study, we examined whether measurement can predict 4 year risk incident diabetes, cardiovascular disease (CVD) mortality general population. For this prospective analysis, included 72,880 participants Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007...
Introduction: The presence of the Thr92Ala polymorphism deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression genes involved in oxidative stress brain tissue, and predict favorable response combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. was hypothesized that homozygous carriers D2-92Ala allele different thyroid hormone parameters, reduced health-related quality life (HRQoL) cognitive...
ABSTRACT Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening, inherited carbohydrate metabolism disorder caused by glucose‐6‐phosphatase (G6Pase) deficiency, which essential for glycogenolysis and gluconeogenesis. GSDIa management includes strict medically prescribed diet that typically daily uncooked cornstarch doses, including overnight, to maintain euglycemia. DTX401 an investigational adeno‐associated virus serotype 8 vector expressing the human G6PC1 gene encodes...
Agranulocytosis is a life-threatening disorder, often caused by drugs. Incidences or risks of drug-induced agranulocytosis are not well known, since it rare.To determine the risk drug-associated as reason for admission to Dutch hospitals, we performed population-based case-cohort study. Hospital discharge data came from Centre Health Care Information, Utrecht, which contains on all general and university hospitals in Netherlands. The reference cohort consisted persons catchment area Pharmaco...
Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence other complications. The aim this study is to assess effect obesity-related conditions HR-QoL. These are i) grade obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), iii) level inflammation.From Dutch LifeLines Cohort Study we included 13,686 aged 18-80 years. HR-QoL was measured RAND 36-Item Health Survey which encompasses eight health domains. We calculated...
Introduction The development of metabolic syndrome (MetS) is influenced by environmental factors such as smoking and alcohol consumption. We determined the combined effects on MetS its individual components. Methods 64,046 participants aged 18–80 years from LifeLines Cohort study were categorized into three body mass index (BMI) classes (BMI<25, normal weight; BMI 25–30, overweight; BMI≥30 kg/m2, obese). was defined according to revised criteria National Cholesterol Education Program's Adult...
Abstract Background Skin autofluorescence ( SAF ) is a noninvasive marker of advanced glycation end products AGE s). In diabetes, higher levels have been positively associated with long‐term complications, cardiovascular morbidity and mortality. Because little known about the factors that influence in nondiabetic individuals, we assessed association clinical lifestyle parameters as well their interactions large‐scale, population performed same analysis type 2 diabetic subgroup. Methods...
Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences dietary patterns and physical activity between MHO unhealthy (MUO). Cross-sectional data 9270 obese individuals (30–69 years) Lifelines Cohort Study was used. defined as no metabolic syndrome risk cardiovascular disease history. MUO ≥2 factors. Sex-specific associations (identified by principal component analysis) with were assessed...
Objective People with type 2 diabetes on insulin are at risk for hypoglycemia. Recurrent hypoglycemia can cause impaired awareness of (IAH), and increase the severe The aim this study was to assess prevalence determinants self-reported IAH in a Dutch nationwide cohort people insulin-treated diabetes. Research design methods Observational Diabetes Pearl, treated primary, secondary tertiary care centers. presence occurrence past year, defined as an event requiring external help recover, were...
1. In order to determine the risk of anaphylaxis as an adverse reaction drugs, a case‐cohort study was performed. Cases consisted all admissions in 1987 and 1988 Dutch hospitals with principal diagnosis, random sample related symptoms. Hospital discharge summaries were classified according probability by blinded Audit Committee. Of probable or possible anaphylaxis, causative agent assessed. The reference cohort persons catchment area pharmacies Netherlands, period between January 1, December...
Introduction To evaluate the prevalence of metabolic syndrome (MetS) and its individual components within sex-, body mass index (BMI)- age combined clusters. In addition, we used age-adjusted blood pressure thresholds to demonstrate effect on MetS elevated pressure. Subjects methods Cross-sectional data from 74,531 Western European participants, aged 18–79 years, were Dutch Lifelines Cohort Study. was defined according revised NCEP-ATPIII. Age-adjusted as recommended by eight reports Joint...
The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported relationship between thyroid function some MetS components or suggested that serum free thyroxine (FT4) triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how relates to prevalence in large population-based study....
The metabolic syndrome (MetS) comprises several cardiometabolic risk factors associated with increased for both type 2 diabetes and cardiovascular disease. Skin autofluorescence (SAF), a non-invasive biomarker of advanced glycation end products accumulation, is complications in subjects diabetes. aim the present study was to examine association between SAF presence MetS as well its individual components general population. For this cross-sectional analysis, we included 78,671 non-diabetic 18...
Abstract Erythrocytosis is a common reason for referral to hematology services and usually secondary in origin. The aim of this study was assess clinical characteristics clonal hematopoiesis (CH) individuals with erythrocytosis the population-based Lifelines cohort (n = 147 167). defined using strict (World Health Organization [WHO] 2008/British Committee Standards Hematology) wide (WHO 2016) criteria. Individuals (strict criteria) concurrent leukocytosis and/or thrombocytosis were 1:2...