Daan W. Loth
A5044363009- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Intracerebral and Subarachnoid Hemorrhage Research
- IL-33, ST2, and ILC Pathways
- Liver Disease and Transplantation
- Hepatitis C virus research
- Frailty in Older Adults
- Sarcoidosis and Beryllium Toxicity Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Respiratory viral infections research
- Nutrition and Health in Aging
Amphia Ziekenhuis
2015-2025
Erasmus MC
2011-2019
Erasmus University Rotterdam
2011-2015
Dutch Health Care Inspectorate
2011-2014
The University of Western Australia
2012
Boston University
2012
ABSTRACT Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of hospitalization and mortality. Yet few associations between VTE genetic variants, all the coagulation pathway, have been established. To identify additional determinants VTE, we conducted two‐stage genome‐wide association study (GWAS) among individuals European ancestry extended cohorts for heart aging research genomic epidemiology (CHARGE) consortium. The discovery GWAS comprised 1,618 incident...
Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence chronic respiratory conditions. Epidemiological evidence highlights role early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk for low FVC later life. Although highly heritable, a small number have been found associated with we aimed at identifying further genetic variants by focusing genes.Per-allele effects 24,728 SNPs 403 involved were...
Prednisone is currently recommended as the first-line treatment for pulmonary sarcoidosis but associated with many side effects. Methotrexate, which a second-line treatment, appears to have fewer effects than prednisone slower onset of action. Data are needed on efficacy and side-effect profile methotrexate compared sarcoidosis. In this multicenter, open-label, noninferiority trial involving patients who had not previously received we randomly assigned patients, in 1:1 ratio, receive or...
Rationale: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic stroke and the increases with severity of airflow limitation. Even though vulnerable carotid artery plaque components, such as intraplaque hemorrhage lipid core, place persons at high events, composition in patients COPD has never been explored.Objectives: To investigate prevalence wall thickening, different their relationship limitation elderly COPD.Methods: This cross-sectional analysis was...
Background Pulmonary hypertension is characterized by increased pulmonary artery pressure and carries an mortality. Population-based studies into are scarce little known about its prevalence in the general population. We aimed to describe distribution of echocardiographically-assessed systolic (ePASP) population, estimate hypertension, identify associated factors. Methods Participants (n = 3381, mean age 76.4 years, 59% women) from Rotterdam Study, a population-based cohort, underwent...
Rationale: Chronic obstructive pulmonary disease (COPD) is a common, complex multisystem in the elderly with multiple comorbidities that significantly impact morbidity and mortality. Although cerebral small-vessel an important cause of cognitive decline age-related disability, it poorly investigated potential systemic manifestation patients COPD.Objectives: To examine whether COPD relates to development location microbleeds, novel marker disease.Methods: Cross-sectional longitudinal analyses...
Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma COPD have common underlying factors, performing genome-wide association studies for both combining the results in meta-analyses. Three loci showed potential involvement diseases: chr2p24.3, chr5q23.1 chr13q14.2, containing DDX1, COMMD10 (both participating nuclear factor (NF) κβ pathway) GNG5P5, respectively. Single nucleotide polymorphisms...
Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various traits has also been demonstrated, and at least 26 loci have reproducibly associated with either FEV 1 (forced expiratory volume in second) or /FVC (FEV /forced vital capacity). Although main effects smoking are well established, question potential gene-by-smoking interaction effect remains unanswered. aim present study was to assess, using a score approach, whether these on...
Treatment of pulmonary sarcoidosis is recommended in case significant symptoms, impaired or deteriorating lung function. Evidence-based treatment recommendations are limited and largely based on expert opinion. Prednisone currently the first-choice therapy leads to short-term improvement Unfortunately, prednisone often has side-effects may be associated with quality life. Methotrexate presently considered second-line therapy, appears have fewer side-effects.The primary objective this trial...
Aim β‐adrenoceptor blockers have been used with caution in patients obstructive lung diseases such as asthma or chronic pulmonary disease ( COPD ), due to the potentially increased airway reactivity and risk of bronchial obstruction. Cardioselective a more beneficial profile than non‐cardioselective can be safely prescribed both cardiovascular . We hypothesized that cardioselective also affect function. Methods This study was performed within R otterdam S tudy, prospective population‐based...
Background Although clopidogrel reduces the incidence of atherothrombotic events, its use is associated with an increased risk major bleeding. Cerebral microbleeds ( CMB s) are indicative subclinical microangiopathy in brain and may prelude symptomatic intracerebral hemorrhage. We examined association between s persons without a history stroke. Methods Results performed cross‐sectional analysis using data from Rotterdam Study, prospective population‐based cohort aged 45 years older. Among...
Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) lung function measures have identified several trait-associated loci, but explain only a modest portion phenotypic variability. We postulated that integrating pathway-based methods with GWASs pulmonary and airflow obstruction would identify broader repertoire genes processes influencing these traits. performed two independent applied gene set enrichment analysis...