A5010010906- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Renal Transplantation Outcomes and Treatments
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Ultrasound and Hyperthermia Applications
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Healthcare Systems and Practices
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Complications and Syndromes
Duke Medical Center
2013-2024
Duke University Hospital
2009-2022
Parker Hannifin (United States)
2008-2021
Duke University
2005-2016
Siemens Healthcare (United States)
2015
Northwestern University
1996-2013
Northwestern University
1994-2013
Astellas Pharma (China)
2013
Astellas Pharma (Canada)
2013
Houston Methodist
2011-2013
Recent studies indicate that magnetic resonance imaging (MRI) after the administration of contrast material can be used to distinguish between reversible and irreversible myocardial ischemic injury regardless extent wall motion or age infarct. We hypothesized results contrast-enhanced MRI predict whether regions abnormal ventricular contraction will improve revascularization in patients with coronary artery disease.
In patients with sarcoidosis, sudden death is a leading cause of mortality, which may represent unrecognized cardiac involvement. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can detect minute amounts myocardial damage. We sought to compare DE-CMR standard clinical evaluation for the identification involvement.Eighty-one consecutive biopsy-proven extracardiac sarcoidosis were prospectively recruited parallel and masked comparison involvement between (1) (2) use consensus...
Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have other vaccines. Whether COVID-19 vaccination may be linked to occurrence of unknown.To describe a group 7 patients with acute over 3 months, 4 whom had recent messenger RNA (mRNA) vaccination.All referred cardiovascular magnetic resonance imaging at Duke University Medical Center were asked participate in prospective outcomes registry. Two searches...
The identification and assessment of myocardial infarction (MI) are important for therapeutic prognostic purposes, yet current recommended diagnostic strategies have significant limitations. We prospectively tested the performance delayed-enhancement magnetic resonance imaging (MRI) with gadolinium-based contrast detection MI in an international, multicenter trial.Patients their first were enrolled acute (< or = 16 days after MI; n=282) chronic (17 to 6 months; n=284) arm then randomized 1 4...
In some patients with heart failure, beta-blockers can improve left ventricular (LV) function and reduce morbidity mortality. We hypothesized that gadolinium-enhanced cardiovascular magnetic resonance imaging (CMR) predict reversible myocardial dysfunction remodeling in failure treated beta-blockers.Forty-five chronic underwent CMR. Contrast using gadolinium was performed to obtain high-resolution spatial maps of scarring viability. Cine assess LV morphology repeated 35 after 6 months...
Baroreflex-mediated parasympathetic stimulation has variable effects on heart rate variability (HRV). We postulated that a quadratic function would describe the relationship between HRV and effect better than linear function.Twenty-nine normal volunteers (15 women; mean age 39+/-12 years) were studied after beta-adrenergic blockade with intravenous propranolol. Five-minute ECG recordings made during graded infusions of phenylephrine nitroprusside to achieve baroreflex-mediated increases...
Despite a wealth of data detailing increased metalloproteinase (MMP)-9 expression and activity in abdominal aortic aneurysms (AAAs), no studies examine the relationship between size MMP-9 expression. Because elastolysis occurs early AAA formation, we hypothesized that would vary with diameter. The purpose this study was to measure mRNA levels AAAs various diameters define expression.MMP-9 were measured by competitive polymerase chain reaction (PCR) using gene-specific external standards cDNA...
This study examined alemtuzumab (anti-CD 52, Campath-1H) and basiliximab 25, Simulect) as induction immunosuppression in kidney transplantation. We used a single-center, nonrandomized, retrospective, sequential design to evaluate outcomes transplant recipients given either (n = 123) or 155) combination with prednisone-free maintenance protocol using tacrolimus mycophenolate mofetil. Kaplan-Meier analyses of long-term patient graft survivals rejection rates were determined according agent,...
Background— Cardiac magnetic resonance (CMR) is considered the reference standard for assessment of left ventricular ejection fraction (LVEF) and myocardial damage. However, few studies have evaluated relationship between CMR findings patient outcome, these, most are small none multicenter. We performed an international, multicenter study to assess prognostic importance routine in patients with known or suspected heart disease. Methods Results— From 10 centers 6 countries, consecutive...
<h3>Importance</h3>Regional left ventricular (LV) wall thinning is believed to represent chronic transmural myocardial infarction and scar tissue. However, recent case reports using delayed-enhancement cardiovascular magnetic resonance (CMR) imaging raise the possibility that may occur with little or no scarring.<h3>Objective</h3>To evaluate patients regional determine burden potential for functional improvement.<h3>Design, Setting, Patients</h3>Investigator-initiated, prospective, 3-center...
Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality unknown.
After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI promoted as an excellent method to delineate AAR. However, evidence supporting validity of this measure AAR indirect, and it never validated with direct anatomic measurements.
Background —Myocardial salvage after acute myocardial infarction is defined clinically by early restoration of flow and long-term improvement in contractile function. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI), performed infarction, indexes salvage. studied the relationship between transmural extent hyperenhancement MRI, flow, recovery Methods Results —The left anterior descending coronary artery was occluded dogs (n=15) for either 45 minutes, 90 or permanently....
Background —The utility of contrast MRI for assessing myocardial viability in stable coronary artery disease (CAD) with left ventricular dysfunction is uncertain. We therefore performed cine and 24 patients CAD regional contractile abnormalities compared findings rest-redistribution 201 Tl imaging dobutamine echocardiography. Methods Results —Delayed enhancement patterns were examined from 3 to 15 minutes after injection 0.1 mmol/kg IV gadolinium diethylenetriamine pentaacetic acid...