A5080697161- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Ultrasound and Hyperthermia Applications
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Pharmaceutical Economics and Policy
- Renin-Angiotensin System Studies
- Ion Transport and Channel Regulation
- Cardiac tumors and thrombi
- Transplantation: Methods and Outcomes
- Signaling Pathways in Disease
- Cardiovascular Syncope and Autonomic Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Adenosine and Purinergic Signaling
- Voice and Speech Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cellular transport and secretion
- Sphingolipid Metabolism and Signaling
- Neurogenesis and neuroplasticity mechanisms
Duke University Hospital
1998-2025
Clinical Research Institute
2013-2024
Duke University
2015-2024
Duke Medical Center
2014-2023
Duke University Health System
2017-2022
Duke Raleigh Hospital
2017-2021
University of Alabama at Birmingham
2006
University of California, San Diego
1992-1998
University of California San Diego Medical Center
1998
Weatherford College
1993
Catheter ablation is effective in restoring sinus rhythm atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain.To determine whether catheter more than conventional medical therapy for improving outcomes AF.The Ablation vs Antiarrhythmic Drug Therapy Atrial Fibrillation trial an investigator-initiated, open-label, multicenter, randomized involving 126 centers 10 countries. A total of 2204 symptomatic patients with AF aged 65 years older or younger 1...
BACKGROUND Recent studies of human type 1 atrial flutter demonstrated reentry in the right atrium and an area slow conduction low posteroseptal atrium. Direct-current catheter ablation this has been only moderately successful preventing recurrence. Therefore, we performed endocardial activation mapping entrainment pace during to determine critical site for radiofrequency arrhythmia. METHODS AND RESULTS Twelve consecutive patients (seven men five women; age, 21-73 years) with (mean cycle...
<h3>Importance</h3> Catheter ablation is more effective than drug therapy in restoring sinus rhythm patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) uncertain. <h3>Objective</h3> To determine whether catheter beneficial conventional for improving QOL AF. <h3>Design, Setting, and Participants</h3> An open-label randomized clinical trial vs 2204 symptomatic AF older 65 years or younger at least 1 risk factor stroke. Patients were enrolled...
In patients with heart failure and atrial fibrillation (AF), several clinical trials have reported improved outcomes, including freedom from AF recurrence, quality of life, survival, catheter ablation. This article describes the treatment-related outcomes enrolled in CABANA trial (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation).The randomized 2204 who were ≥65 years old or <65 ≥1 risk factor stroke at 126 sites to ablation pulmonary vein isolation drug therapy...
Observational data suggest that catheter ablation may be safe and effective to treat younger older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes outcomes according age at entry in the CABANA (Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation).Patients fibrillation ≥65 years of age, or <65 ≥1 risk factor stroke, were randomly assigned drug therapy. The primary outcome was a composite death, disabling...
In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with drug therapy by intention-to-treat, but improve quality life and freedom from atrial fibrillation recurrence. heart failure subgroup, improved both survival life. Cost-effectiveness was a prespecified secondary point.
Clinically detected atrial fibrillation (AF) is associated with a significant increase in mortality and other adverse cardiovascular events. Since the advent of effective methods for AF rhythm control, investigators have attempted to determine how much these prognostic effects could be mitigated by restoration sinus (SR) whether method used mattered.
ABSTRACT Background The majority of data on left bundle branch area pacing (LBBAP) are a lumenless lead. Data the safety and effectiveness stylet driven leads comparatively lacking. Methods We retrospectively analyzed 265 patients who underwent attempted LBBAP with an 7842 (Boston Scientific, Marlborough, MA) lead in Duke University Health System between 1/1/2020 9/1/2023. Outcomes interest included post‐operative helix extension (≥2 rotations beyond tip), complications, parameters. A nested...
Pharmacological control of rapid ventricular response to atrial fibrillation may be difficult in some patients. Alternative treatments, including curative surgery or atrioventricular (AV) node ablation with pacemaker implantation, have significant potential morbidity. In view evidence that dual AV nodal physiology exist a percentage the population, even those without reentrant tachycardia, we postulated might achieved by radiofrequency (RF) catheter region slow pathway its short refractory...
In the pancreatic acinar cell, hormonal stimulation causes a rise in intracellular free Ca2+ concentration by activating inositol 1,4,5-trisphosphate-mediated release of from stores (Berridge, M. J., and Irvine, R. F. (1989) Nature 341, 197-205). The released is, for most part, extruded necessitating mechanism entry reloading (Putney, J. W., Jr. (1990) Cell Calcium 11, 611-624; Rink, T. FEBS Lett. 268, 381-385). However, neither depletion-activated nor signal that activates it is known. We...
Among patients with atrial fibrillation (AF), women are less likely to receive catheter ablation and may have more complications durable results. Most information about sex-specific differences after comes from observational data. We prespecified an examination of outcomes by sex in the 2204-patient CABANA trial (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation).
LAA Thrombus Among Anticoagulated AF Patients. Introduction: Catheter‐directed atrial fibrillation (AF) ablation is contraindicated among patients with left appendage (LAA) thrombus. The prevalence of thrombus fully anticoagulated undergoing unknown. Methods and Results: We retrospectively evaluated the 192 consecutive between July 2006 January 2009. Seven (3.6%) had evidence on transesophageal echocardiogram (TEE) despite being warfarin (international normalized ratio [INR] 2–3) for 4 weeks...
Influence of atrial fibrillation (AF) type on outcomes seen with catheter ablation vs. drug therapy is incompletely understood. This study assesses the impact AF treatment in Catheter Ablation Antiarrhythmic Drug Therapy for Atrial Fibrillation Trial (CABANA).
Cardiac implanted electronic device (CIED) pocket and systemic infection remain common complications with traditional CIEDs are associated high morbidity mortality. Leadless pacemakers may be an attractive pacing alternative for many patients following complete hardware removal a CIED by eliminating surgical pocket-related as well lower risk of recurrent complications.To describe use outcomes leadless pacemaker implantation extraction system due to infection.Patient characteristics...
Introduction: Left atrial radiofrequency catheter ablation (RFA) is gaining acceptance as treatment for drug‐refractory fibrillation (AF). This therapy has been associated with esophageal injury and atrioesophageal fistula formation causing death. Methods: We describe 3 patients undergoing AF during real‐time monitoring of luminal temperature. Results: observed heating the esophagus short duration low power RFA, at either left or right pulmonary vein ostia. Cryoablation ostium in one patient...