A5101781171- Geophysical and Geoelectrical Methods
- Geophysical Methods and Applications
- Monoclonal and Polyclonal Antibodies Research
- Seismic Waves and Analysis
- Nerve injury and regeneration
- Seismic Imaging and Inversion Techniques
- Fibroblast Growth Factor Research
- Traditional Chinese Medicine Analysis
- Gastric Cancer Management and Outcomes
- Hydrocarbon exploration and reservoir analysis
- Radiomics and Machine Learning in Medical Imaging
- Methane Hydrates and Related Phenomena
- Liver Disease Diagnosis and Treatment
- Geological and Geophysical Studies
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycosylation and Glycoproteins Research
- Biological and pharmacological studies of plants
- Bone Metabolism and Diseases
- Kruppel-like factors research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Biochemical effects in animals
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
Yangtze University
2018-2025
Daqing Oilfield General Hospital
2025
Xi’an Children’s Hospital
2024
Institut de Recherches sur la Catalyse et l'Environnement de Lyon
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Xi'an Shiyou University
2024
Kunming Medical University
2009-2023
Research Institute of Petroleum Exploration and Development
2023
Hunan Province Chest Hospital
2023
State Key Laboratory of Food Science and Technology
2023
Abstract The development of bone-rebuilding anabolic agents for treating bone-related conditions has been a long-standing goal. Genetic studies in humans and mice have shown that the secreted protein sclerostin is key negative regulator bone formation. More recently, administration sclerostin-neutralizing monoclonal antibodies rodent pharmacologic inhibition results increased formation, mass, strength. To explore effects primates, we administered humanized antibody (Scl-AbIV) to gonad-intact...
Fibroblast growth factor 21 (FGF21), a hormone with short half-life, has consistently shown strong pharmacological efficacy. We first assessed the efficacy of murine recombinant FGF21 in C57BL6 lean mice for 5 wk. then generated long-acting molecule by fusing Fc to variant human (hrFGF21) that contained two engineered mutations [L98R, P171G; Fc-FGF21(RG)] and tested it diet-induced obese rhesus monkeys. compared its metabolic properties those hrFGF21. Groups were treated 36 d different doses...
Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism. Previously, we engineered an Fc fusion FGF21 variant with two mutations, Fc-FGF21(RG), to extend the half-life reduce aggregation in vivo degradation of FGF21. We now describe new developed extreme C-terminal improve binding affinity β-Klotho. demonstrate, by introducing one additional mutation located at C terminus (A180E), molecule, Fc-FGF21(RGE), has gained many improved...
Background and purposeIt is well known that inflammation influence chronic subdural hematoma (CSDH) formation to a large extent. Atorvastatin has pleiotropic effects on restraining promoting angiogenesis besides its cholesterol-lowering function. Hence, atorvastatin may induce anti-inflammation facilitate therapeutic for (SDH).MethodsAdult male Wistar rats were subjected SDH successful establishment of was confirmed by magnetic resonance imaging (MRI). The treatment initiated 6 hours after...
Sclerostin antibody (Scl-Ab) and parathyroid hormone (PTH) are bone-forming agents that have different modes of action on bone, although a study directly comparing their effects has not been conducted. The present investigated the comparative quantitative these two over time bone at organ, tissue, cellular level; specifically, level osteoblast (Ob) lineage in adolescent male female rats. Briefly, eight-week old Sprague-Dawley rats were administered either vehicle, Scl-Ab (3 or 50mg/kg/week...
Severe sepsis has a high fatality rate, but no clinical indices for prognosis have been established. In recent years, the renin-angiotensin system (RAS) received considerable attention. However, data on RAS are inconsistent. Therefore, aim of present study was to assess significance in sepsis. Blood samples were collected from patients, who met diagnostic criteria severe sepsis, day 1 (D1) and 3 (D3). For each sample, levels angiotensin II (AngII), angiotensin-converting enzyme (ACE)...
To evaluate the safety and potential efficacy of AMG 557, a fully human antibody directed against inducible T cell costimulator ligand (ICOSL) in patients with systemic lupus erythematosus (SLE) arthritis.In this phase Ib, randomized, double-blind, placebo-controlled study, received 557 210 mg (n = 10) or placebo weekly for 3 weeks, then every other week 10 additional doses. The corticosteroid dosage was tapered to ≤7.5 mg/day by day 85, immunosuppressants were discontinued 29. Primary end...
Background/Aims: Parkinson’s disease (PD) is a frequently occurring condition that resulted from the loss of midbrain neurons, which synthesize neurotransmitter dopamine. In this study, we established mouse models PD to investigate expression microRNA-128 (miR-128) and mechanism through it affects apoptosis dopamine (DA) neurons excitatory amino acid transporter 4 (EAAT4) via binding axis inhibition protein 1 (AXIN1). Methods: Gene microarray analysis was performed screen differentially...
ABSTRACT Postmenopausal osteoporosis is a chronic disease wherein increased bone remodeling reduces mass and strength. Antiresorptive agents including bisphosphonates are commonly used to mitigate loss fracture risk. Osteoclast inhibition via denosumab (DMAb), RANKL inhibitor, newer approach for reducing risk in patients at fracture. The safety of transitioning from bisphosphonate therapy (alendronate; ALN) DMAb was examined mature ovariectomized (OVX) cynomolgus monkeys (cynos). One day...
β-Secretase 1 (BACE1) represents an attractive target for the treatment of Alzheimer’s disease. In course development a novel small molecule BACE1 inhibitor (AMG-8718), retinal thinning was observed in 1-month toxicity study rat. To further understand lesion, investigational conducted whereby rats were treated daily with AMG-8718 month followed by 2-month treatment-free phase. The earliest detectable change retina increase autofluorescent granules pigment epithelium (RPE) on day 5; however,...
Background— Intravenous prostacyclin is approved for treating pulmonary arterial hypertension (PAH), but it has a short half-life and must be delivered systemically via an indwelling intravenous catheter. We hypothesize that localized jugular vein delivery of prostacyclin-producing cells may provide sustained therapeutic effects without the limitations systemic delivery. Methods Results— generated vector expressing human cyclooxygenase isoform 1 synthase fusion protein produces from...
// Beibei Wu 1,4,* , Yan Wei 1,* Yujing Wang 1,4 Tao Su 1 Lei Zhou 5 Ying Liu and Rongqiao He 1,2,3 State Key Laboratory of Brain Cognitive Sciences, Institute Biophysics, Chinese Academy Beijing, China 2 Mental Health, Psychology, 3 Alzheimer's Disease Center, Beijing for Disorders, Capital Medical University, 4 University Animal Experiment Core Facility Protein Research, * These authors have contributed equally to this work Correspondence to: He, email: Keywords : D-Ribose, memory...
Summary Introduction Neural stem cells ( NSC s) are the most promising for cell replacement therapy Parkinson's disease PD ). However, a majority of transplanted s differentiated into glial cells, thereby limiting clinical application. Previous studies indicated that chronic neuroinflammation plays vital role in degeneration midbrain DA mDA ) neurons, which suggested developing potential therapies by targeting inflammatory processes. Thus, Nurr1 (nuclear receptor‐related factor 1),...
BACKGROUND:In the recent years, there has been increasing interest in traditional Chinese medicine as a neuroprotective nutrient management of chronic neurodegenerative disease, such diabetic cognitive decline. Astragalus polysacharin (APS), herb extract, is biologically active treatment for diseases. Therefore, present study, we investigated effects APS (20 mg/kg) on diabetes-induced memory impairments Sprague-Dawley (SD) rats and explored its underlying mechanisms action. MATERIAL AND...
<title>Abstract</title> Geothermal resource is a kind of renewable green and clean energy stored in the earth's interior. Under impetus global revolution goal “double-carbon”, development utilization geothermal has become an important strategy for all countries world. Magnetotelluric (MT) sounding method, which not shielded by high-resistance layers provides high resolution low-resistance layers, unique advantages revealing system structures, delineating hydrothermal geoelectric assessing...
To address the challenge of dynamic monitoring during grouting operations in coal mine fault zones under pressurized mining, this study proposes Borehole–Tunnel Joint Resistivity Method (BTJRM). By integrating three-dimensional (3D) electrode arrays both tunnels and boreholes with 3D resistivity inversion technology, approach enables fully automated underground data acquisition real-time processing, facilitating comprehensive grout propagation. A case was conducted on a project, where tunnel...
Abstract When developing Block D with small well spacing, severe stress interference occurs between wells. Optimizing fracturing operation parameters and clarifying the fracture propagation patterns post-fracturing are key to enhancing development efficiency. To mitigate inter-well inter-cluster in multi-layer, three-dimensional network of reduce repeated stimulation, a detailed geological model was established based on characteristics in-situ distribution. Under constraints this model,...
Gastrointestinal stromal tumor (GIST) is a rare of the small bowel, which can be difficult to diagnose and has varied clinical outcome.This retrospective review diagnosis, management, outcome 32 patients diagnosed with primary bowel GIST from single center comparison findings previously published cases.Retrospective data patient records, endoscopic imaging findings, surgical procedures, histology immunohistochemistry, was conducted.Data median age 56 years including 50% men women were...
Cognitive dysfunction is a very severe consequence of diabetes, but the underlying causes are still unclear. Recently, cerebellum was reported to play an important role in learning and memory. Since long-term depression (LTD) primary cellular mechanism for cerebellar motor learning, we aimed explore LTD pathways diabetic rats therapeutic effect gastrodin. Diabetes induced by single injection streptozotocin into adult Sprague-Dawley rats. Motor ability assessed beam walk test. Pathological...