A5100442034- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Vitamin D Research Studies
- Phytoestrogen effects and research
- Spinal Cord Injury Research
- Bioactive Compounds and Antitumor Agents
- Autoimmune Bullous Skin Diseases
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Foreign Body Medical Cases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related Molecular Pathways
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Nutritional Studies and Diet
- Pancreatitis Pathology and Treatment
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Tea Polyphenols and Effects
- Congenital gastrointestinal and neural anomalies
- Connective Tissue Growth Factor Research
Sichuan University
2025
Zunyi Medical University
2025
Beijing Children’s Hospital
2020-2024
Capital Medical University
2020-2024
National Health and Family Planning Commission
2024
Jiangsu Cancer Hospital
2024
Nanjing Medical University
2024
Shantou University
2024
Shantou University Medical College
2024
Jiangxi Provincial People's Hospital
2023
Background Elexacaftor/Tezacaftor/Ivacaftor (ETI) has demonstrated significant efficacy in enhancing clinical outcomes for patients with cystic fibrosis (CF). Despite this, comprehensive post-marketing assessments of its adverse drug events (ADEs) remain insufficient. This study aims to analyze the ADEs associated ETI using U.S. FDA Adverse Event Reporting System (FAERS). Methods We conducted a pharmacovigilance analysis utilizing FAERS data from Q4 2019 Q3 2024. Reports related were...
Abstract Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors cyclin-dependent kinases (CDK) demonstrated pre-clinical activity in DLBCL, however many stalled clinical development. Here we show that AZD4573, a selective inhibitor CDK9, restricted growth DLBCL cells. CDK9 inhibition (CDK9i) resulted rapid changes the transcriptome and...
Cancer cells metabolize glucose mainly by glycolysis and are well adapted to metabolic stress. Pim1 is an oncogene that promotes colorectal cancer ( CRC ) growth metastasis, its expression positively correlated with progression. However, the mechanism underlying overexpression during progression role of in metabolism remains unclear. In present study, we discovered was significantly upregulated response deprivation‐induced stress AMP ‐activated protein kinase signaling. promoted cell...
Abstract The results of a cDNA array revealed that protocadherin gamma subfamily A, 9 (PCDHGA9) was significantly decreased in SGC-7901 gastric cancer (GC) cells compared with GES-1 normal and strongly associated the Wnt/β-catenin transforming growth factor-β (TGF-β)/Smad2/3 signaling pathway. As member cadherin family, PCDHGA9 functions both cell–cell adhesion nuclear signaling. However, its role tumorigenicity or metastasis has not been reported. In present study, we found GC tissues...
ABSTRACT Whether rapamycin has neuroprotective effects in spinal cord injury remains controversial. The present study shows that protects neurons from death after by inhibiting the secondary inflammatory response. of were tested using a myeloperoxidase assay, Western blotting, immunohistochemistry, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. experimental results showed injury, reduced numbers activated microglia neutrophils damage zone, lowered expression...
Abstract Background While the cities in China which spinal cord injury (SCI) studies have been conducted previously are at forefront of medical care, northwest is relatively underdeveloped economically, and epidemiological characteristics SCI rarely reported this region. Methods The survey software developed was used to analyze data patients treated with from 2014 2018. sociodemographic patients, including name, age, sex, occupation, were recorded. following record data, obtained physical...
Whether circulating histones in gut lymph contribute to organ failure and impact of chaiqin chengqi decoction (CQCQD) on severe acute pancreatitis (SAP) remain elusive. To verify the role SAP evaluate effect CQCQD them. Sodium taurocholate was retrogradely infused into pancreatobiliary duct induce rodents. Various regimens were administered intragastrically or via duodenum followed by dynamic collection rats. The endothelial cell viability lymphocytes determined. Components identified...
Breast and gynecological cancers are among the leading causes of death in women worldwide, illustrating urgent need for innovative treatment options. We identified MYT1 as a promising new therapeutic target breast cancer using PandaOmics, an AI-driven discovery platform. The synthetic lethal relationship tumor cell lines with CCNE1 amplification enhanced this rationale. Through structure-based drug design, we developed series novel, potent, highly selective inhibitors specifically targeting...
Disseminated nontuberculous mycobacteria ( NTM ) infection with concurrent IgG4‐related lymphadenopathy has not been reported. We described a patient neutralizing autoantibodies to interferon‐gamma IFN ‐γ) and elevated levels of serum IgG4 presenting generalized reactive dermatosis. Histologically, lymph nodes LN s) showed effaced nodal architecture polymorphic infiltrates, mimicking angioimmunoblastic T‐cell lymphoma. Both the absolute number ratio IgG4+ plasma cells IgG+ were increased....
Chinese steamed bread supplemented with flaxseed flour can be recommended as a dietary product health benefits.
Immune checkpoint inhibitors (ICI) have shown great promise in treating advanced or metastatic colorectal cancer (mCRC), especially for CRC patients with deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H). For the remainder of presenting proficient (pMMR) stable (MSS) low (MSI-L), ICI showed a low-level response. This study describes 57-year-old Chinese man diagnosed pMMR MSS IVb liver metastasis. Primarily, patient was administered two consecutive treatments, one...
Abstract Objective In this study, we aimed to enhance the treatment protocols and help understand harm caused by accidental ingestion of magnetic beads children. Methods Data were collected from 72 children with multiple gastrointestinal perforations or obstructions. The pediatric patients divided into a perforation non-perforation group. data for analysis included gender, age, medical history, place residence (rural urban), symptoms along educational background caregiver, location quantity...
IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression rare these lymphomas. We report 7-year-old Chinese male with lymphoma. Evaluation his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated strong extensive CD10 positivity. Despite lack t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our highlights clinicopathologic features IFR4/MUM1-positive...
The present study aimed to identify polypeptides that specifically bond breast cancer stem cells from a phage display random 12 peptide library, in addition the affinity and specificity of polypeptides. A library was screened using as targets isolated MDA-MB-231 cell line serum-free culture technique with hs578bst subtract-screening cells. Positive specific binding clones were amplified sent for sequencing. positive subsequently identified by ELISA 3,3'-diaminobenzidine staining. results...
The role of deregulated cellular metabolism, particularly lipid in gastrointestinal stromal tumors (GISTs) remains unclear. Through data mining published transcriptomes, we examined metabolism-regulating drivers differentially upregulated high-risk cases and identified monoglyceride lipase (MGLL) as the top-ranking candidate involved GIST progression. MGLL expression status was three cell lines two independent sets primary localized GISTs. mRNA abundance immunoexpression determined 70...
Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms complex radiological findings. However, studies that describe features of different among Chinese pediatric adult patients are limited. We analyzed clinical, pathological 31 lymphomas mediastinum, compared them to 21 patients. Although several were identified adults, presented T-cell lymphoblastic lymphoma/T-cell acute leukemia (T-LBL/T-ALL) classical...
Hirschsprung's disease (HSCR, colonic aganglionosis) is an oligogenic entity that usually requires mutations in RET and other interacting loci. Decreased levels of expression may lead to the manifestation HSCR. We previously showed transcription was decreased due alteration TITF1 binding site by two HSCR-associated promoter single nucleotide polymorphisms (SNPs). This prompted us investigate whether DNA alterations could play a role HSCR affecting RET-regulatory properties protein. Our...