A5001384627- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- RNA modifications and cancer
- CAR-T cell therapy research
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- 14-3-3 protein interactions
- Inflammatory Biomarkers in Disease Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Ear and Head Tumors
- Molecular Biology Techniques and Applications
- Inflammatory mediators and NSAID effects
Kaohsiung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2015-2024
Princess Margaret Cancer Centre
2024
University of Toronto
2024
Weatherford College
2020
Stornoway Historical Society
2015
The University of Texas MD Anderson Cancer Center
2010-2014
Roche (Switzerland)
2013
Baylor College of Medicine
2013
McGill University
2013
250 Background: First-line (1L) pembro + chemo significantly improved survival versus placebo (pbo) in patients (pts) with advanced esophageal cancer after a median follow-up of 22.6 mo the randomized phase 3 KEYNOTE-590 study (NCT03189719). We report 5-yr data. Methods: Eligible pts had locally advanced/metastatic adenocarcinoma or squamous cell carcinoma esophagus (ESCC), Siewert type I gastroesophageal junction adenocarcinoma; measurable disease per RECIST v1.1; and ECOG PS 0 1. Pts were...
Abstract Purpose: No standard treatment exists for platinum-refractory, recurrent/metastatic nasopharyngeal cancer (NPC). This phase II study (NCT02605967) evaluated progression-free survival (PFS) of spartalizumab, an antiprogrammed cell death protein-1 (PD-1) monoclonal antibody, versus chemotherapy, in NPC. Patients and Methods: with nonkeratinizing NPC who progressed on/after platinum-based chemotherapy were enrolled. Spartalizumab was dosed 400 mg once every 4 weeks, received per...
Background A malignant tracheoesophageal/bronchoesophageal fistula (TEF) is a life-threatening complication of esophageal squamous cell carcinoma. feeding gastrostomy/jejunostomy had been the most common treatment method for patients with TEF before era stenting. The aim this retrospective study to compare prognosis carcinoma treated an metallic stent those gastrostomy/jejunostomy. Methods We retrospectively reviewed total 1011 between 1996 and 2011 at Kaohsiung Chang Gung Memorial Hospital,...
Organophosphate flame retardants (OPFRs) are emerging and widespread environmental pollutants with potential health hazards, including nephrotoxicity. However, the exposure patterns nephrotoxic of OPFRs yet to be investigated in patients chronic kidney disease (CKD). We conducted a cross-sectional study involving 166 CKD stratified by estimated glomerular filtration rate (eGFR) severity proteinuria. The urinary concentrations 10 OPFR compounds were measured evaluate patterns. Clinical...
Abstract Background This study was to evaluate the effect of excision repair cross-complementation group 1(ERCC1) expression on response cisplatin-based induction chemotherapy (IC) followed by concurrent chemoradiation (CCRT) in locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) patients. Methods Fifty-seven patients with HNSCC who received IC CCRT from January 1, 2006 through 2008. Eligibility criteria included presence biopsy-proven without a prior history or...
Purpose: The preplanned exploratory analysis of the BERIL-1 trial presented here aimed to identify biomarkers response combination buparlisib and paclitaxel.Patients Methods: was a multicenter, randomized, double-blind, placebo-controlled phase II study. Patients with recurrent or metastatic squamous cell carcinoma head neck (SCCHN) progressing on/after one previous platinum-based chemotherapy regimen in setting were treated either plus paclitaxel placebo paclitaxel. Archival tumor tissue...
In this study, we assessed plasma biomarkers to identify cognitive impairment in Parkinson's disease (PD) patients by applying ultra-sensitive immunomagnetic reduction-based immunoassay (IMR).The study enrolled 60 PD and 28 age- sex-matched normal controls. Complete function assessments were performed on participants using the Mini-Mental State Examination (MMSE) Clinical Dementia Rating. with an MMSE score of ≦26 defined as having impairment. Meanwhile, a 99mTc-TRODAT-1 scan was levels...
241 Background: At interim analysis of the phase 3, randomized, double-blind KEYNOTE-590 (NCT03189719) study, 1L pembrolizumab (pembro) + chemotherapy (chemo) vs chemo alone provided superior OS, PFS, and ORR with a manageable safety profile in patients (pts) untreated, advanced/unresectable or metastatic adenocarcinoma esophageal squamous cell carcinoma (ESCC) Siewert type 1 esophagogastric junction (EGJ). We report efficacy, safety, health-related quality life (HRQoL) results an additional...
Clinical practice guidelines suggest routine screening for distress among cancer patients immediate early psychiatric care. However, previous studies focusing on psychological inpatients in Taiwan are scant. Thus, the aim of this study was to evaluate prevalence and related factors mental illness Taiwan.This conducted as a retrospective chart review general hospital southern Taiwan. Cancer were regularly screened by nursing staff using Distress Thermometer 12-item Chinese Health...
Inflammation plays a role in the development of cancer. This study aims to analyze prognostic value neutrophil-to-lymphocyte ratio (NLR) and other clinicopathological determinants early-stage (cT1/T2N0) tongue cancer.A total 262 patients were selected from our institute's cancer database between 2004 2011. Optimal cutoff NLR lymph node density (LND) determined statistically using receiver operating characteristic curve analysis for survival prediction. The 5-year overall (OS),...
Introduction . Systemic inflammation with elevated oxidative stress causing neuroinflammation is considered a major factor in the pathogenesis of Parkinson’s disease (PD). The interface between systemic circulation and brain parenchyma blood-brain barrier (BBB), which also plays role maintaining neurovascular homeostasis. Vascular cell adhesion molecule-1 (VCAM-1) microRNAs (miRNAs) regulate vessel endothelial function, neoangiogenesis, and, turn, neuronal homeostasis regulation, such that...
Hemodialysis (HD) patients are susceptible to extended spectrum beta-lactamase (ESBL)-producing bacterial infections. Because the optimal treatment and clinical significance of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) HD access-related bacteremia remain unclear, we conducted this retrospective study determine outcomes treated with either flomoxef or a carbapenem.The eligibility criterion was fistula graft- catheter- related ESBL-Kp in on maintenance HD. The characteristics antibiotic...
Abstract The present study investigated clinical outcomes and prognostic factors of patients with locally advanced synchronous esophageal squamous cell carcinoma (ESCC) head/neck (HNSCC) receiving curative concurrent chemoradiotherapy (CCRT), determined whether ESCC/HNSCC had worse prognosis compared to isolated ESCC patients. Using propensity score matching method, we 60 matched Compared patients, significantly (13.5 months versus 17.2 months, P = 0.01), more grade 3–4 CCRT toxicity, higher...
Liver metastasis has been found to affect outcome in prostate cancer and colorectal cancer, but its role lung is unclear. The current study aimed evaluate the impact of de novo liver (DLM) on stage IV non-small cell (NSCLC) outcomes examine whether tyrosine kinase inhibitors (TKI) reverse poor prognosis patients with DLM epidermal growth factor receptor (EGFR)-mutant NSCLC. Among 1392 newly diagnosed NSCLC patients, 490 disease treated between November 2010 March 2014 at Kaohsiung Chang Gung...
Organophosphate flame retardants (OPFRs) are emerging environmental pollutants that can be detected in water, dust, and biological organisms. Certain OPFRs disrupt lipid metabolism animal models cell lines. However, the effects of on human remain unclear. We included 1,580 participants (≥20 years) from 2013–2014 National Health Nutrition Examination Survey (NHANES) to explore relationship between OPFR exposure biomarkers. After adjusting for confounding factors, results showed one-unit...
Sirtuin 1 (SIRT1) regulates DNA repair and metabolism by deacetylating target proteins. SIRT1 may be oncogenic because its overexpression has been detected in many cancers. The aim of the present study was to clarify prognostic role patients with esophageal squamous cell carcinoma (ESCC) evaluate effect inhibitor vitro.The expression evaluated immunohistochemically 155 surgically resected ESCC staining results were semiquantitatively Immunoreactive Scoring System. clinical features treatment...
The most beneficial neoadjuvant chemoradiotherapy (nCRT) combination for esophageal squamous cell carcinoma (ESCC) in Asia remains uncertain. Herein, we compared the carboplatin/paclitaxel (CROSS) regimen versus cisplatin/5-fluorouracil (PF) with 41.4-50.4 Gy of radiotherapy.Patients were stratified according to their nCRT regimen: CROSS + 41.4-45.0 (CROSS), PF 45.0 (PF4500) or 50.4 (PF5040). Propensity score matching by inverse probability treatment weighting (IPTW) was used balance...
14-3-3ζ is overexpressed in more than 40% of breast cancers, but its pathophysiologic relevance to tumorigenesis has not been established. Here, we show that overexpression sufficient induce a transgenic mouse model cancer. MMTV-LTR promoter-driven HA-14-3-3ζ mice (MMTV-HA-14-3-3ζ) developed mammary tumors, whereas control did not. Whey acidic protein (WAP-HA-14-3-3ζ) hyperplastic lesions and showed increased susceptibility carcinogen-induced tumorigenesis. When crossed with MMTV-neu mice,...