Hyperammonemia has been reported to be associated with patients who receive valproic acid (VPA) therapy. This study aimed determine the risk factors for hyperammonemia in epilepsy treated VPA. One hundred and fifty-eight adult aged older than 17 years received VPA therapy were enrolled into this study. Blood samples taken during interictal state analyzed blood level of ammonia. Statistical analysis was conducted between different groups patients. The results showed that frequency 27.8%...

Summary Endothelial dysfunction leads to worse cognitive performance in Alzheimer’s dementia (AD). While both cerebrovascular risk factors and endothelial lead activation of vascular cell adhesion molecule-1 (VCAM-1), intercellular (ICAM-1) E-selectin, it is not known whether these biomarkers extend the diagnostic repertoire reflecting intracerebral structural damage or performance. A total 110 AD patients 50 age-matched controls were enrolled. Plasma levels VCAM-1, ICAM-1 E-selectin...

Denosumab is widely used for bone diseases with increased resorption. Its effectiveness in patients severe secondary hyperparathyroidism on dialysis unclear. This study aimed to evaluate the efficacy and safety of denosumab who are dialysis. 6-month prospective, open-labeled evaluated 12 (five women, seven men; mean age 53.5±3.8 y). All had intact PTH (iPTH; > 1000 pg/mL), low mass (T-score < −1.0 SD), pain were poor surgical candidates. Serum calcium, phosphorus, alkaline phosphatase (AP),...

Status epilepticus may decrease mitochondrial biogenesis, resulting in neuronal cell death occurring the hippocampus. Sirtuin 1 (SIRT1) functionally interacts with peroxisome proliferator-activated receptors and γ coactivator 1α (PGC-1α), which play a crucial role regulation of biogenesis. In Sprague-Dawley rats, kainic acid was microinjected unilaterally into hippocampal CA3 subfield to induce bilateral seizure activity. SIRT1, PGC-1α, other key proteins involving biogenesis amount DNA were...

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol present in a variety of plants, including the skin grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown offer protective effects against number cardiovascular neurodegenerative diseases, stroke, epilepsy. This study examined neuroprotective effect resveratrol on biogenesis hippocampus following experimental status epilepticus. Kainic...

The association between increased neutrophil-to-lymphocyte ratio (NLR) and multiple sclerosis has been demonstrated in several studies. monocyte-to-lymphocyte (MLR) is an emerging biomarker for disease monitoring. Moreover, there not a published Taiwanese study to date.To investigate the correlation of NLR, MLR white blood cell (WBC) count as possible biomarkers predicting 2-year relapse patients with (MS).A total 641 MS were enrolled present January 1, 2001, December 31, 2018. We collected...

Omega-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have been associated with slower rates of cognitive decline. We investigated the association between omega-3 PUFAs function in patients Alzheimer's disease (AD) receiving acetylcholinesterase inhibitors (AChEIs). This was a prospective cohort study using registered data. Patients AD AChEIs were recruited from 1 May 2016 to 30 April 2019 followed up for two years. Their daily diet...

Secondary hyperparathyroidism (SHPT) may worsen with administration of denosumab in chronic renal failure patients low bone mass.This study aimed to evaluate the short-term effect coadministration calcitriol and on PTH secretion parathyroid structure incidence adverse effects SHPT was a 24-week, open-label at Kaohsiung Veterans General Hospital Kaohsiung, Taiwan.Dialysis (intact hormone [iPTH] > 800 pg/mL) mass (T score < -2.5) were enrolled.Patients received (60 mg) doses adjusted achieve...

In this study, we assessed plasma biomarkers to identify cognitive impairment in Parkinson's disease (PD) patients by applying ultra-sensitive immunomagnetic reduction-based immunoassay (IMR).The study enrolled 60 PD and 28 age- sex-matched normal controls. Complete function assessments were performed on participants using the Mini-Mental State Examination (MMSE) Clinical Dementia Rating. with an MMSE score of ≦26 defined as having impairment. Meanwhile, a 99mTc-TRODAT-1 scan was levels...

Abstract Background Temporal lobe epilepsy (TLE) is a common form of focal epilepsy. Serum biomarkers to predict cognitive performance in TLE patients without psychiatric comorbidities and the link with gray matter (GM) atrophy have not been fully explored. Methods Thirty-four 34 sex - age-matched controls were enrolled for standardized tests, neuroimaging studies as well measurements serum levels heat shock protein 70 (HSP70), S100ß (S100ßP), neuronal specific enolase (NSE), plasma nuclear...

Amyloid load, as measured by florbetapir positron emission tomography (PET) standardized uptake value ratio (SUVr), has high specificity in the diagnosis of Alzheimer disease (AD). As posterior cingulate cortex (PCC) represents densely amyloid-affected regions early AD, we hypothesized that amyloid load within key hubs default mode networks (DMN) may result local or distant interconnected gray matter (GM) volume atrophy, thereby affecting cognitive performance. Thirty AD patients with a...

Purpose: Neuronal activity during face matching shows co-activation of the fusiform gyrus (FG) and areas along ventral visual network. To elucidate role β-amyloid (Aβ) deposition in relation to gray matter (GM) atrophy within network, it is crucial delineate pathological mechanisms Alzheimer's disease (AD) on facial discrimination. Methods: Comprehensive cognitive assessments GM analysis by using magnetic resonance imaging AV-45 positron emission tomography (PET) were studied 44 patients...

Falling is a serious issue among elderly community dwellers, often resulting in disability. We aimed to investigate the risk factors for falls dwellers.We recruited 232 participants from multiple learning and care centers, who provided their information through questionnaires. They were divided into two groups, according falling events after 1-year follow-up. Univariate multivariate logistic regressions used statistical analysis.A total of 64 reported fall at The group comprised older single...

While carbon monoxide (CO) intoxication often triggers multiple intraneuronal immune- or inflammatory-related cascades, it is not known whether the pathological processes within affected regions evolve equally in long term. To understand neurodegenerative networks, we examined 49 patients with a clinical diagnosis of CO related to charcoal burning suicide at chronic stage and compared them 15 age- sex-matched controls. Reconstructions degenerative networks were performed using T1 magnetic...

Inflammatory processes play a pivotal role in the degenerative process of Alzheimer's disease. In humans, biallelic (C/T) polymorphism promoter region (position-511) (rs16944) interleukin-1 beta gene has been significantly associated with differences secretory capacity beta. this study, we investigated whether functional mediates brain networks patients We enrolled total 135 disease (65 males, 70 females), and their gray matter structural covariance using 3D T1 magnetic resonance imaging...

Increasing numbers of patients with different types dementia have resulted in the increasing medical care loads. It is not known whether explanatory factors for recurrent or prolong hospitalization were driven by subtypes dementia. We analyzed 203 aged >65-year-old a clinical diagnosis Alzheimer disease (AD), vascular (VaD), Parkinsonism-related (PRD). With 4-year follow-up period, logistic regression analyses used to identify predictors diagnosis, cerebrovascular risk factors, chronic...

Background & Objectives Cardiovascular disease remains the most common cause of death for patients on chronic dialysis. End stage renal undergoing dialysis imposed to reduce phosphorus intake, which likely contributes development vegetarian diet behaviors. Vegetarian diets are often lower in protein content, contradiction recommendation that a high is followed by The purpose study was investigate effects nutritional and cardiovascular status patients. Design, Setting, Participants,...