A5084735703- Health disparities and outcomes
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Diet and metabolism studies
- Physical Activity and Health
- Restless Legs Syndrome Research
- Metabolomics and Mass Spectrometry Studies
- Nerve injury and regeneration
- Obsessive-Compulsive Spectrum Disorders
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Cancer survivorship and care
- Gut microbiota and health
- Health, Environment, Cognitive Aging
- Maternal Mental Health During Pregnancy and Postpartum
- Metabolism and Genetic Disorders
- Neurological disorders and treatments
- Aging and Gerontology Research
- Nutritional Studies and Diet
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cancer-related cognitive impairment studies
- Family Caregiving in Mental Illness
- Health and Wellbeing Research
- Childhood Cancer Survivors' Quality of Life
- Dementia and Cognitive Impairment Research
University of Oxford
2022-2024
Kaohsiung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2015-2024
MRC Unit for Lifelong Health and Ageing
2023
University College London
2022-2023
Creative Commons
2015
Christie's
2015
Importance Metabolomics reflect the net effect of genetic and environmental influences thus provide a comprehensive approach to evaluating pathogenesis complex diseases, such as depression. Objective To identify metabolic signatures major depressive disorder (MDD), elucidate direction associations using mendelian randomization, evaluate interplay human gut microbiome metabolome in development MDD. Design, Setting Participants This cohort study used data from participants UK Biobank (n = 500...
Background To assess how timing, frequency and maintenance of being physically active, spanning over 30 years in adulthood, is associated with later-life cognitive function. Methods Participants (n=1417, 53% female) were from the prospective longitudinal cohort study, 1946 British birth cohort. Participation leisure time physical activity was reported five times between ages 36 69, categorised into: not active (no participation activity/month); moderately (participated 1–4 times/month); most...
Clinical practice guidelines suggest routine screening for distress among cancer patients immediate early psychiatric care. However, previous studies focusing on psychological inpatients in Taiwan are scant. Thus, the aim of this study was to evaluate prevalence and related factors mental illness Taiwan.This conducted as a retrospective chart review general hospital southern Taiwan. Cancer were regularly screened by nursing staff using Distress Thermometer 12-item Chinese Health...
Brain-derived neurotrophic factors are known to be related the psychopathology of major depressive disorder. However, studies focusing on drug-naïve first-episode patients still rare. Over a 6-year period, we examined serum brain-derived levels in with disorder and compared them sex-matched healthy controls. We also investigated relationships between levels, suicidal behavior, Hamilton Depression Rating Scale scores before after 4-week antidepressant treatment. The baseline 71 were...
Brain-derived neurotrophic factors (BDNF) are known to be related the psychopathology of schizophrenia. However, studies focussing on drug-naïve first-episode schizophrenia still rare.Over a 5-year period, we investigated serum BDNF levels in patients with and compared them age- sex-matched healthy controls. We also explored association between antipsychotic doses, positive negative syndrome scale (PANSS) scores, before after 4-week treatment.The baseline 34 were significantly lower than...
Abstract Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other’s psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, suicidal ideation depression severity patients caregivers. In total, 175 were recruited at a medical center from August 2018 May 2020. Structural equation modeling (SEM) was used examine actor/partner well-being both The most common...
Abstract Experimental models shows that bioenergetic homeostasis changes with increasing age based on apolipoprotein E ( APOE ) gene. However, such link dementia remains unclear in population. We used H 1 -NMR metabolome blood from 118,021 random-selected participants UK Biobank (n=118,021 individuals), and identified 56 metabolites associated the risk of dementia. In without developing during follow-up, 82% (46/56) are also reaction time, shares metabolite signatures total brain volume....
Objective: Parkinson disease (PD) is a debilitating neurodegenerative disease. Caring for an individual with PD can have variety of negative physical and psychological effects on caregivers which may challenge their ability to continue in caretaking role. The aim this study was assess the prevalence associated factors depressive disorders individuals using standardized instruments. Methods: This used cross-sectional design consecutive sampling. Study participants were recruited from...
Objectives Brain-derived neurotrophic factor (BDNF) has been associated with the psychopathology of both major depressive disorder (MDD) and schizophrenia (SZ). However, studies focusing on accuracy BDNF levels to differentiate between these patients healthy controls (HCs) have rare. Methods Over a discrete ten-year period, we investigated serum in MDD or SZ compared them HCs. Results We found 224 samples be lower than those 390 HCs (p = 0.007), but not 273 MDD. Male tended male 0.083). The...
Depression is a common comorbidity in patients with Parkinson’s disease (PD) and their caregivers. This study aimed to compare the prevalence risk factors of depression between PD In total, 113 101 caregivers were enrolled. Patients assessed using Mini International Neuropsychiatric Interview, Unified Disease Rating Scale (UPDRS), Activities Daily Living (ADL), Hospital Anxiety Scale, Beck Hopelessness Brief Fatigue Inventory, Connor–Davidson Resilience Big Five Inventory-10. Caregivers also...
Data on the efficacy of antipsychotics as monotherapy for obsessive-compulsive disorder (OCD) are inadequate. This report presents case a patient with OCD that was successfully treated risperidone monotherapy. Assessments revealed significant reductions in symptoms after treatment (4 mg/d). suggests beneficial effect comorbid schizoaffective disorder.
We assessed the association between leisure time physical activity patterns across 30 years of adulthood with a range in vivo Alzheimer's disease-related neurodegenerative markers and cognition, their interplay, at age 70. Participants from 1946 British birth cohort study prospectively reported five times ages 36 69 were dichotomized into (i) not active (no participation/month) (ii) (participated once or more/month) further derived into: (0) never (not active); (1) before 50's only (≤43...
Parkinson's disease (PD) is a progressive, neurodegenerative disorder and commonly comorbid with depression. The aim of this cross-sectional study was to assess morbidity associated factors depression in patients PD. In total, 181 PD were enrolled assessed using the Mini-International Neuropsychiatric Interview. Of sample, 51% had at least one psychiatric diagnosis. most prevalent depressive (27.6%), followed by rapid eye movement sleep behavior (9.9%), insomnia (8.8%), adjustment (2.8%)....
Abstract The pathogenesis of depression is complex involving the interplay genetic and environmental risk factors including diet, lifestyle gut microbiome. Metabolomics studies may shed light on these factors. We study over 63,000 individuals 8462 cases with a lifetime major 5403 recurrent from UK Biobank profiled for nuclear magnetic resonance (NMR) spectroscopy based metabolites Nightingale platform. identify 124 that are associated depressive disorder (MDD), 49 novel associations. No...
Abstract Background We assess if, and at which ages during 30 years of adulthood, undertaking leisure time physical activity (LTPA) is associated with brain health age 70, to what extent metrics explain the positive association between LTPA later‐life cognition. Method Participants from British 1946 birth cohort prospectively reported five times 36 69. Metrics were categorised into: not active (no participation/month); (participated once or more/month); summed. underwent 18 F‐florbetapir...
Abstract Background The pathogenesis of dementia and depression is complex involving the interplay genetic environmental risk factors including diet, life‐style gut microbiome. Dementia co‐occur metabolomics studies may shed light on various factors. Methods We have studied metabolome 118,466 individuals 8462 cases with a history major (MDD) 1,364 patients who developed during follow‐up from UK Biobank (UKB). human was profiled using Nightingale platform. Result For both disorders, we find...
Abstract Background We aim to assess how the timing of being physically active in adulthood is associated with later‐life cognitive function; and estimate what extent these effects are explained by pathways including earlier life influences, cardiovascular mental health. Method Data from participants (n = 1417, 53% female) British 1946 birth cohort were included. Physical activity was assessed across at ages 36, 43, 53, 60 69 interviews categorised into: 0)Not active; 1)Moderately...