A5042692668- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- NF-κB Signaling Pathways
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Pluripotent Stem Cells Research
- HER2/EGFR in Cancer Research
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- Immune cells in cancer
- interferon and immune responses
- Pancreatic and Hepatic Oncology Research
- Neonatal Respiratory Health Research
- Zebrafish Biomedical Research Applications
- Adipose Tissue and Metabolism
- Hematopoietic Stem Cell Transplantation
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- RNA modifications and cancer
Josep Carreras Leukaemia Research Institute
2023-2025
Centro de Investigación Biomédica en Red de Cáncer
2023-2025
Hospital Del Mar
2024-2025
University of Arkansas System
2025
Hospital del Mar Research Institute
2023-2024
Vall d'Hebron Institute of Oncology
2013-2024
Vall d'Hebron Hospital Universitari
2013-2023
Navarrabiomed
2023
Universitat Politècnica de Catalunya
2015-2021
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2015-2021
Epigenetic changes through altered DNA methylation have been implicated in critical aspects of tumor progression, and extensively studied a variety cancer types. In contrast, our current knowledge the aberrant genomic tumor-associated fibroblasts (TAFs) or other stromal cells that act as coconspirators progression is very scarce. To address this gap knowledge, we conducted genome-wide profiling on lung TAFs paired control (CFs) from non-small cell patients using HumanMethylation450...
Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in aorta- gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic clusters (IAHC) along with progenitors (HPC). The signalling mechanisms that distinguish HSCs HPCs are unknown. Notch signaling is essential for arterial specification, IAHC formation HSC activity, but current studies on how segregates these different fates inconsistent. We now demonstrate activity highest a subset of, GFI1 + ,...
250 Background: First-line (1L) pembro + chemo significantly improved survival versus placebo (pbo) in patients (pts) with advanced esophageal cancer after a median follow-up of 22.6 mo the randomized phase 3 KEYNOTE-590 study (NCT03189719). We report 5-yr data. Methods: Eligible pts had locally advanced/metastatic adenocarcinoma or squamous cell carcinoma esophagus (ESCC), Siewert type I gastroesophageal junction adenocarcinoma; measurable disease per RECIST v1.1; and ECOG PS 0 1. Pts were...
Large cell carcinoma (LCC) is a rare and aggressive lung cancer subtype with poor prognosis no targeted therapies. Tumor-associated fibroblasts (TAFs) derived from LCC tumors exhibit premature senescence, coculture of pulmonary lines selectively induces fibroblast which in turn drives growth invasion. Here we identify MMP1 as overexpressed specifically lines, show that expression by cells necessary for induction senescence consequent tumor promotion both culture mouse models. We also MMP1,...
Abstract Background The MORPHEUS platform comprises multiple open-label, randomized, phase Ib/II trials designed to identify early efficacy and safety signals of treatment combinations across cancers. Atezolizumab (anti-programmed cell death 1 ligand [PD-L1]) was evaluated in combination with PEGylated recombinant human hyaluronidase (PEGPH20). Methods In 2 randomized trials, eligible patients advanced, previously treated pancreatic ductal adenocarcinoma (PDAC) or gastric cancer (GC)...
Abstract Recent findings suggest that Hematopoietic Stem Cells (HSC) and progenitors arise simultaneously independently of each other already in the embryonic aorta-gonad mesonephros region, but it is still unknown how their different features are established. Here, we uncover IκBα ( Nfkbia , inhibitor NF-κB) as a critical regulator HSC proliferation throughout development. balances retinoic acid signaling levels together with epigenetic silencer, PRC2, specifically HSCs. Loss decreases...
The DNA damage repair kinase ATM is phosphorylated by the NF-κB pathway IKKα, resulting in enhanced through nonhomologous end-joining pathway. Thus, inhibition of IKKα enhances efficacy cancer therapy based on inducing damage. Here, we found a role for IKK regulatory subunit NEMO mediated and IKKα. Exposure to damaging agents induced interaction with preformed ATM-IKKα complex, which was required target active chromatin efficient but not activating ATM. Recognition damaged IKKα-NEMO-ATM...
Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described are most frequent clinically diagnosed CdLS patients. The molecular mechanisms driving phenotypes not understood. In addition to its canonical role sister chromatid cohesion, implicated spatial organization of genome. Here, we investigate transcriptome patient-derived primary fibroblasts observe downregulation genes...
The retinal extracellular matrix (ECM) provides architectural support, adhesion and signal guidance that controls development. Decellularization of the ECM affords great potential to tissue engineering; however, how structural affects in vitro development, differentiation maturation ocular cells remains be elucidated. Here, mouse porcine retinas were decellularized protein profile analyzed. Acellular (arECM) scaffolds then repopulated with human iPSC-derived pigment epithelial (RPE) or...
Maintenance of pluripotency is a multifactorial process in which NF-κB negative regulator. Our previous work identified chromatin role for IκBα, the master regulator signaling, that critical proper regulation various tissue stem cells. Here, we found IκBα accumulates specifically fraction pluripotent embryonic depletion does not affect NF-kB-dependent transcription, but causes profound epigenetic rewiring cells, including alterations H3K27me3, histone mark catalyzed by Polycomb repression...
Maintenance of pluripotency is a multifactorial process in which NF-κB negative regulator. Our previous work identified chromatin role for IκBα, the master regulator signaling, that critical proper regulation various tissue stem cells. Here, we found IκBα accumulates specifically fraction pluripotent embryonic depletion does not affect NF-kB-dependent transcription, but causes profound epigenetic rewiring cells, including alterations H3K27me3, histone mark catalyzed by Polycomb repression...
Background: Eradication of SS is hampered by its genetic and molecular heterogeneity. A better understanding the putative commonalities underlying oncogenicity may help to provide more efficient therapeutic strategies against this devastating disease. Purpose: The present work analyzes whole transcriptome different patient-derived cells identify expression patterns, functional programs expressed gene mutations that clues on new options for patients Methods: Mononuclear were recovered Ficoll...
Selection for water consumption could impact broiler breeders’ immune capabilities. To assess these impacts of selection based on the conversion ratio (WCR), three trials were conducted using breeders from modern random bred (MRB), low (L)WCR, and high (H)WCR lines. Ten- to 11-week-old male broilers received intradermal (i.d.) growing feather (GF)-pulp injections LPS (Trial 1) or PGN 2), local (GF-pulp) systemic (blood) inflammatory responses over 24 h 72 p.i., respectively. Measurements...
4043 Background: HER2 overexpression occurs in < 20% of GEC, and T-based front-line therapy improves survival. HER3 is overexpressed 87% GEC associated with poor prognosis. activated by its ligand heregulin (HRG) to form a potent signaling heterodimer emerging as key tumorigenic node. MM-111, bispecific antibody designed inhibit HRG-activated HER2+ tumors, was evaluated second-line treatment advanced combination weekly PTX TRAS. Methods: Patients (pts) who progressed following...
Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in embryonic pancreas. However, Rest knockout mice failed show abnormal numbers endocrine cells, suggesting not major regulator differentiation. Using different conditional allele enables profound inactivation, we observed marked...
Biomarker-selected strategies, including immune checkpoint inhibitors (ICIs), have marked a paradigm change in the treatment of advanced gastric and gastroesophageal junction adenocarcinoma (GEA), showing improved survival over standard chemotherapy.1-8
Gene expression (GE) analyses on blood samples from marathon and half-marathon runners have reported significant impacts the immune inflammatory systems. An ultra-marathon trail (UMT) represents a greater effort due to its more testing conditions. For first time, we report genome-wide GE profiling in group of 16 participating an 82 km UMT competition. We quantified their differential profile before after race using HuGene2.0st microarrays (Affymetrix Inc., California, US). The results...
Abstract We previously demonstrated that the NF-κB inhibitor IκBα binds chromatin together with PRC2 to regulate a subset of developmental- and stem cell-related genes. This alternative function has been elusive in both physiological disease conditions because predominant role as negative regulator NF-κB. here uniquely characterize specific residues allow generation separation-of-function (SOF) mutants are defective for either NF-κB-related (SOF ΔNF-κB ) or chromatin-related ΔH2A,H4...