A5101710450- Autophagy in Disease and Therapy
- Radio Frequency Integrated Circuit Design
- Nonmelanoma Skin Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cutaneous Melanoma Detection and Management
- Nuclear Engineering Thermal-Hydraulics
- Cancer and Skin Lesions
- Analog and Mixed-Signal Circuit Design
- Helicobacter pylori-related gastroenterology studies
- Nuclear and radioactivity studies
- Cellular transport and secretion
- Advancements in Semiconductor Devices and Circuit Design
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Photonic and Optical Devices
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Lysosomal Storage Disorders Research
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Cyclone Separators and Fluid Dynamics
- Cancer Genomics and Diagnostics
- Electronic Packaging and Soldering Technologies
- Particle Dynamics in Fluid Flows
Juntendo University
1984-2025
Jichi Medical University
2018-2024
Isesaki Fukushima Hospital
2020-2024
Yamaguchi University
2002-2024
Jichi Medical University Hospital
2024
University of Miyazaki
2024
Niigata College of Nursing
2024
Kyoto University
2002-2024
Fukushima Medical University
2024
Weatherford College
2023
Studies have revealed many analogies between podocytes and neurons, these may be key to elucidating the pathogenesis of podocyte injury. Cathepsin D (CD) is a representative aspartic proteinase in lysosomes. Central nervous system neurons CD-deficient mice exhibit form lysosomal storage disease with phenotype resembling neuronal ceroid lipofuscinoses. In kidney, role CD has not been fully explored. Herein, we generated podocyte–specific CD–knockout that developed proteinuria at 5 months age...
// Takashi Ueno 1, 2 , Takahiro Tsuchikawa 1 Kanako C. Hatanaka Yutaka Tomoko Mitsuhashi Yoshitsugu Nakanishi Takehiro Noji Toru Nakamura Keisuke Okamura Yoshihiro Matsuno and Satoshi Hirano Department of Gastroenterological Surgery II, Division Surgery, Faculty Medicine, Graduate School Hokkaido University, Sapporo, Hokkaido, Japan Surgical Pathology, University Hospital, Correspondence to: Tsuchikawa, email: tsuchi-t@med.hokudai.ac.jp Keywords: extrahepatic cholangiocarcinoma; PD-L1; tumor...
Adriamycin (ADR) nephrosis in mice has been extensively studied and enabled a greater understanding of the processes underlying progression renal injury. Dendrin is novel component slit diaphragm with proapoptotic signaling properties, it accumulates podocyte nucleus response to glomerular injury mice. The present study re-evaluated chronic progressive nephropathy ADR localization dendrin human glomerulopathy.To investigate dendrin, mouse model glomerulosclerosis was used, which injected...
This paper presents a possible BiCMOS solution for direct conversion receiver (DCR) QPSK communication systems such as personal handy-phone system (PHS). DCR chips reported are constant-amplitude modulation FSK or GMSK. However, no chip has been yet,because 2nd-order nonlinearity often strongly deteriorates sensitivity systems. That is, amplitude components in converted down into spurious baseband signals, while and/or GMSK do not suffer from nonlinearity. A including an LNA is fabricated...
Structures of 8-G-1-[p-YC6H4Se(O)]C10H6 [1 (G = H), 2 F), 3 Cl), and 4 Br): Y H, OMe, OCH2Ph, t-Bu, Me, Cl, NO2] (1-C10H7)2SeO (5) are investigated by the X-ray crystallographic analysis. 1 all A with regard to naphthyl group (1 (A)), where Se−CAr Se−O bonds perpendicular parallel plane, respectively. Those 2−4 also A. Since structures 8-G-1-(p-YC6H4Se)C10H6 [7 8 9 Br)] B, results exhibit that B 7−9 change dramatically introduction O atoms. The factor determine 1−4 is called dependence....
The contribution of low-density lipoprotein receptor-related protein-1 (LRP-1) to the brain-to-blood amyloid-beta peptide (A beta) efflux transport across blood-brain barrier (BBB) remains controversial. purpose present study was clarify whether or not LRP-1 plays a role in A beta at BBB. After microinjection [(125)I]activated alpha2-macroglobulin (alpha 2M), typical ligand, into mouse secondary somatosensory cortex region under ketamine-xylazine anesthesia, residual radioactivity...
Tumour budding is a risk factor for poor prognosis in various cancers. buds may present an epithelial-mesenchymal transition (EMT) morphological phenotype. This study aimed to elucidate the prognostic impact of tumour grade and its association with clinicopathological EMT-related features perihilar cholangiocarcinoma (PHCC) or distal (DCC).Subjects included 195 PHCC 115 DCC patients. The numbers different patients were stratified postoperative survival using recursive partitioning technique....
Recently, endoscopic submucosal dissection (ESD) using the pocket-creation method (PCM) has been developed as a kind of third space endoscopy. PCM enables complete under lesion before making circumferential incision [1]. Using this method, wide should be created with small entrance where small-diameter endoscope is more desirable.
Aim This study aimed to evaluate the real‐world efficacy and safety of 12‐week sofosbuvir/velpatasvir (SOF/VEL) treatment for patients with decompensated liver cirrhosis caused by hepatitis C virus (HCV) infection. Methods A total 72 Child–Pugh (CP) class B or were enrolled. We evaluated sustained virologic response at 12 weeks after end (SVR12), adverse events (AEs), changes in function. Results All participants had genotype 1 2 HCV At baseline, numbers CP 59 13, respectively. The overall...
Several improvements on the original method of Yoshiki and coworkers for histological identification osteoid matrix in decalcified bone are described this report. The first, fixation with neutral buffered formalin, a popular stable fixative, should produce better tissue morphology ensure easy handling any laboratory. second is simple test aged cyanuric chloride. Aged reagents show poor or no solubility methanol have almost effect differential staining matrix. third an application organic...
AbstractAlthough a conjugation of overexpressed GABARAP to phospholipid has been reported be activated during starvation-induced autophagy, it is unclear whether endogenous GABARAP-conjugation also under starvation conditions. We observed that little GABARAP-phospholipid conjugate (GABARAP-PL) accumulated in mouse liver and kidney conditions, while LC3-phospholipid (LC3-II) accumulated. A small amount GABARAP-PL was the heart independent starvation. In rapamycin-treated HEK293 cells, there...
Although spleen stiffness has recently been identified as potential surrogate marker for portal hypertension, the relationship between and hypertension not fully elucidated. We attempted to determine liver or presence of ascites esophageal varices by acoustic radiation force impulse (ARFI) imaging. A total 33 chronic hepatitis C (CHC) patients (median age 68; range 51-84) were enrolled. evaluated indicators well clinical biochemical parameters. Fourteen healthy volunteers used validating...
Early gastric cancers (EGCs) of the elevated type or with submucosal invasion are easily found by routine endoscopy. However, most early challenging to detect because subtle morphological color differences from surrounding atrophic mucosa and intestinal metaplasia. Linked imaging (LCI) enhances mucosal difference, making it easier EGCs. The aim this study is clarify advantages possible disadvantages LCI for screening obscure EGC.A total 665 malignant lesions resected using endoscopic...
Abstract The mammalian oviductal lumen is a specialized chamber that provides an environment strictly regulates fertilization and early embryogenesis, but the regulatory mechanisms to gametes zygotes are unclear. We evaluated regulation of embryonic development using Ovgp1 (encoding humoral factor, OVGP1)-knockout golden hamsters. experimental results revealed following: (1) female Ovgp1-knockout hamsters failed produce litters; (2) in oviducts animals, fertilized eggs were sometimes...
This paper describes a simple engine model at idling and it applies particularly to idle speed control. Through linearization in the neighborhood of nominal operating points (650 rpm), is expressed as reduced-order constant coefficient state variable (2 state) model. It was produced through system order-reduction method. The strategy for controlling uses Linear Quadratic Integral (LQI) optimal control theory. tracking controller designed using model, performance index minimized.
Background and study aims Ultrathin endoscopy causes a minimal gag reflex has effects on cardiopulmonary function. Linked color imaging (LCI) is useful for detection of malignancies in the digestive tract. The aim this was to clarify whether LCI with ultrathin facilitates early gastric cancer (EGC) despite its lower resolution compared high-resolution white light (WLI) standard endoscopy. Patients methods This retrospective analysis prospectively collected video, including consecutive 166...
This 2.7 V low-distortion, low-noise, fourth order gm-C filter adopts real resistors for terminations and transconductors of wide common mode input range. Degradation in passband ripple due to mismatch between termination is alleviated by design centering. The achieves a stopband third-order intermodulation intercept point (IIP3) 49 dBm, IIP3 14 an input-referred noise 28 nV//spl radic/(Hz) rejection ratio 70 dB. cutoff frequency tuned 200 kHz using reference resistor. consumes 11.5...
前報で得られた垂直上昇空気-水系環状ミスト流を特徴づけている主要パラメータ(じょう乱波に関する速度,平均通過ひん度およびそれらの平均間隔,みかけの液膜厚さおよび基底液膜厚さ)の実験データをもとに相関式を作成した.はとんどの主要パラメータは供試管径が12mm付近で極値をもつ傾向があるが,この傾向を表す関数を数個定義し,それらを用いることによって精度良い相関式を得た.さらに従来の相関との比較検討を加えた.