A5001170662- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- Language, Metaphor, and Cognition
- Maternal and fetal healthcare
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Diabetes and associated disorders
- Inflammatory Myopathies and Dermatomyositis
- Complement system in diseases
- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Multiple Sclerosis Research Studies
- Sympathectomy and Hyperhidrosis Treatments
- Genetic and Kidney Cyst Diseases
- Osteomyelitis and Bone Disorders Research
- Spondyloarthritis Studies and Treatments
- Myasthenia Gravis and Thymoma
Nara Medical University
2012-2024
Nara Prefecture General Medical Center
2017-2022
Jichi Medical University
1983
Nihon University
1983
Shiga University of Medical Science
1981
A hereditary dysfibrinogenemia associated with defective aggregation of fibrin monomers was found in a 39-yr-old female and the members her immediate family, who had all been asymptomatic. The abnormality probably due to an impaired polymerization site exposed DD domain two adjacent molecules, because plasmic fragment derived from propositus' cross-linked bound far less tightly insolubilized normal E than that one. Its complementary fibrin, which by thrombin cleavage, D fibrinogen, available...
Placental growth factor (PlGF) contributes to atherogenesis through vascular inflammation and plaque destabilization. High levels of PlGF may be associated with mortality cardiovascular disease, but the relationship between level adverse outcomes in patients CKD is unclear. We conducted a prospective cohort study 1351 consecutive participants enrolled Novel Assessment Risk management for Atherosclerotic diseases (NARA-CKD) April 1, 2004, December 31, 2011. During median follow-up 3 years,...
Metastatic myocardial calcification is a frequent cause of heart failure in hemodialysis patients. However, early detection difficult, often resulting poor prognosis. A 47-year-old man with hemodialysis-dependent end-stage renal disease presented progressive dyspnea. Levels serum phosphate, calcium, and intact parathyroid hormone were poorly controlled. He developed pain his right thumb 1 year before presentation, the gradually increased extended to entire hand. Hand radiography month...
Diabetic nephropathy, a pathologically diagnosed microvascular complication of diabetes, is strong risk factor for cardiovascular events, which mainly involve arteries larger than those affected in diabetic nephropathy. However, the association between nephropathy pathological findings and events has not been well studied. We aimed to investigate whether are closely associated with event development.This retrospective cohort study analysed 377 people type 2 diabetes biopsy-proven median...
Abstract Peritonitis is a critical complication of peritoneal dialysis (PD). Investigators have reported the risk peritonitis in patients on continuous ambulatory (CAPD) versus automated (APD), but available evidence predominantly based observational studies which failed to report connection type. Our understanding relationship between and PD modality thus remained insufficient. We studied 285 participants who began treatment 1997 2014 at three hospitals Nara Prefecture Japan. matched 106...
There are fewer reports about whether the presence of hematuria affects progression chronic kidney disease in patients with diabetic nephropathy. We analyzed microscopic nephropathy is a risk factor for end-stage (ESKD).The present study was retrospective cohort biopsy-proven recruited 397 nephropathy, which confirmed by renal biopsy between June 1981 and December 2014 followed them until October 2018 or death. Patients before were defined as group (n=91), remainder no-hematuria (n=306). The...
Abstract Aim To examine whether serum β2‐microglobulin (β2‐MG) could improve the prediction performance for kidney failure with replacement therapy (KFRT) among patients diabetic nephropathy (DN). Methods Patients biopsy‐proven DN at Nara Medical University Hospital were included. The exposure of interest was log‐transformed β2‐MG levels measured biopsy. outcome variable KFRT. Multivariable Cox regression models and competing‐risk models, all‐cause mortality as a competing event, performed....
Systemic reactive AA amyloidosis is a life-threatening complication of chronic inflammatory diseases. Anti-interleukin-6 receptor, tocilizumab (TCZ), has been shown to improve clinical symptoms patients with amyloidosis, accompanied regression the amyloid deposition. We report case evaluated by histology multiple organs before and after TCZ treatment. A woman in her 60s rheumatoid arthritis was referred our hospital because cardiac renal dysfunction. gastric biopsy revealed deposition...
Abstract Technique failure remains a frequent cause of peritoneal dialysis (PD) withdrawal. Many post‐commencement predictors PD technique have been identified, while predialysis remained unclear. The aim this study was to identify indices for in patients. We recruited 206 consecutive patients who were treated at Nara Medical University Hospital between 1 April 1997 and 31 December 2012. Forty‐eight excluded because transition from hemodialysis (HD) or withdrawal within 3 months, leaving 158...
<b><i>Background:</i></b> Placental growth factor (PlGF), a member of the vascular endothelial (VEGF) family, has recently emerged as predictor survival and cardiovascular risk. Along with others, we have shown an independent association between PlGF events in CKD patients, but not much is known about patients receiving dialysis. <b><i>Methods:</i></b> We studied 205 dialysis undergoing cardiac catheterization at Nara Medical University April...
Placental growth factor (PlGF) is a member of the vascular endothelial family that acts as pleiotropic cytokine capable stimulating angiogenesis and accelerating atherogenesis. Soluble fms-like tyrosine kinase-1 (sFlt-1) antagonizes PlGF action. Higher levels sFlt-1 have been associated with cardiovascular events in patients chronic kidney disease, yet little known about their relationship adverse outcomes on peritoneal dialysis (PD). The aim this study was to investigate association...
Mice were injected daily with a radioprotector WR-2721 after inoculation Ehrlich's ascites tumor cells. Increases in weight of mice, volume ascitic fluid and number cells per mouse reduced by the administration 5 mg/mouse drug, indicating suppyessive effect on growth But treatment mg/ caused earlier death tumor-bearing mice.
症例は76歳，男性．1995年4月に右腎細胞癌に対して右腎摘除術を受けた後，徐々に腎機能が低下し，2006年2月に血液透析が導入された．前医で維持透析中，右副腎腫瘍およびエリスロポエチン抵抗性貧血が出現し，2008年5月に当科へ紹介された．副腎腫瘍は転移性と考えられた．また，MRI T2強調像で肝は著明な低信号を示し，肝ヘモクロマトーシスが疑われた．血清フェリチン値は2,314ng/mLと高値で，前医での輸血および鉄剤投与による鉄過剰症が考えられた．右副腎腫瘍摘除術（病理所見：腎細胞癌の転移）後，骨髄生検が行われた．所見は骨髄異形成症候群で，環状鉄芽球の割合が20％であったことから，鉄芽球性不応性貧血と診断された．高齢かつ複数の重篤な合併症のため，免疫抑制療法より輸血療法の安全性が高いと判断し，2008年6月より鉄芽球性不応性貧血による貧血に対しては赤血球濃厚液2単位/週の輸血，鉄過剰症に対しては経口鉄キレート剤（デフェラシロクス：エクジェイド®）投与を開始した．デフェラシロクスは500 mg/日から，血清フェリチン値が減少傾向を示すまで徐々に増量し，血清フェリチンが1,000...